Incidental Mutation 'IGL02829:Miip'
ID 361338
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Miip
Ensembl Gene ENSMUSG00000029022
Gene Name migration and invasion inhibitory protein
Synonyms D4Wsu114e
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL02829
Quality Score
Status
Chromosome 4
Chromosomal Location 147945235-147953176 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 147947518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 214 (N214I)
Ref Sequence ENSEMBL: ENSMUSP00000134085 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030886] [ENSMUST00000119975] [ENSMUST00000172710]
AlphaFold A2A7Y5
Predicted Effect probably benign
Transcript: ENSMUST00000030886
AA Change: N214I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000030886
Gene: ENSMUSG00000029022
AA Change: N214I

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
low complexity region 60 69 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000119975
AA Change: N214I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000113897
Gene: ENSMUSG00000029022
AA Change: N214I

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:MIIP 41 382 1.4e-142 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141166
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141534
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156374
Predicted Effect probably benign
Transcript: ENSMUST00000172710
AA Change: N214I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000134085
Gene: ENSMUSG00000029022
AA Change: N214I

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
low complexity region 60 69 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174081
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173034
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bbs9 A G 9: 22,490,780 (GRCm39) T303A probably damaging Het
Bet1 T A 6: 4,086,795 (GRCm39) M1L probably benign Het
Bicc1 A C 10: 70,794,710 (GRCm39) V149G probably damaging Het
Braf C A 6: 39,604,662 (GRCm39) L655F possibly damaging Het
Cd101 A G 3: 100,925,881 (GRCm39) probably benign Het
Cobll1 T C 2: 64,956,389 (GRCm39) K290E probably damaging Het
Col6a5 A T 9: 105,811,506 (GRCm39) I671K unknown Het
D130052B06Rik A C 11: 33,573,864 (GRCm39) T154P probably benign Het
Dglucy A C 12: 100,837,663 (GRCm39) H602P probably damaging Het
Fbxo34 A G 14: 47,767,146 (GRCm39) I220V probably benign Het
Gm42878 A G 5: 121,675,266 (GRCm39) V101A probably damaging Het
Gsdmc4 A G 15: 63,764,497 (GRCm39) L381P probably benign Het
Ifi208 C A 1: 173,510,406 (GRCm39) P187H probably damaging Het
Lrrc37a A T 11: 103,382,000 (GRCm39) C2473S unknown Het
Mrc2 A G 11: 105,227,533 (GRCm39) T589A possibly damaging Het
Mtss1 A G 15: 58,930,277 (GRCm39) probably benign Het
Mypn T C 10: 63,028,365 (GRCm39) R233G probably benign Het
Naip6 A T 13: 100,437,273 (GRCm39) C417S probably benign Het
Or13f5 C T 4: 52,826,027 (GRCm39) P210L probably damaging Het
Or4c111 A C 2: 88,844,021 (GRCm39) L129W probably damaging Het
Or8k37 T A 2: 86,469,599 (GRCm39) Y151F possibly damaging Het
Pcsk1 T C 13: 75,274,955 (GRCm39) Y515H probably damaging Het
Pla2g2e T A 4: 138,607,747 (GRCm39) Y42* probably null Het
Polh A T 17: 46,483,828 (GRCm39) L479Q possibly damaging Het
Prr36 T A 8: 4,265,278 (GRCm39) R157S possibly damaging Het
Reck T A 4: 43,891,014 (GRCm39) C51S probably damaging Het
Rev3l A G 10: 39,701,236 (GRCm39) D1911G probably damaging Het
Scgb1b27 A T 7: 33,721,173 (GRCm39) probably null Het
Sema4g G A 19: 44,981,188 (GRCm39) R47Q possibly damaging Het
Serinc1 A T 10: 57,400,061 (GRCm39) Y158* probably null Het
Slc15a2 C A 16: 36,577,555 (GRCm39) G435C possibly damaging Het
Tbc1d17 C A 7: 44,498,296 (GRCm39) probably benign Het
Tenm4 C T 7: 96,544,205 (GRCm39) Q2074* probably null Het
Tns3 A G 11: 8,469,564 (GRCm39) C244R probably damaging Het
Vmn2r2 A T 3: 64,026,172 (GRCm39) probably benign Het
Vmn2r44 T A 7: 8,380,879 (GRCm39) Q338L possibly damaging Het
Wdr70 C T 15: 8,006,463 (GRCm39) D363N possibly damaging Het
Yipf7 A T 5: 69,698,434 (GRCm39) S24R probably benign Het
Other mutations in Miip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00531:Miip APN 4 147,950,322 (GRCm39) missense probably damaging 1.00
IGL02134:Miip APN 4 147,949,735 (GRCm39) splice site probably benign
IGL03350:Miip APN 4 147,946,979 (GRCm39) missense probably benign 0.01
R0200:Miip UTSW 4 147,946,720 (GRCm39) missense probably damaging 0.99
R1647:Miip UTSW 4 147,949,691 (GRCm39) missense probably benign 0.02
R1783:Miip UTSW 4 147,950,231 (GRCm39) missense probably damaging 1.00
R1848:Miip UTSW 4 147,947,549 (GRCm39) missense probably damaging 0.99
R1944:Miip UTSW 4 147,950,422 (GRCm39) missense probably benign 0.15
R3615:Miip UTSW 4 147,950,371 (GRCm39) missense probably benign 0.00
R3616:Miip UTSW 4 147,950,371 (GRCm39) missense probably benign 0.00
R3882:Miip UTSW 4 147,945,509 (GRCm39) missense possibly damaging 0.93
R4579:Miip UTSW 4 147,945,518 (GRCm39) missense probably damaging 1.00
R5183:Miip UTSW 4 147,947,526 (GRCm39) missense probably damaging 1.00
R6054:Miip UTSW 4 147,950,135 (GRCm39) missense probably benign 0.00
R6056:Miip UTSW 4 147,946,792 (GRCm39) missense probably damaging 1.00
R6304:Miip UTSW 4 147,947,540 (GRCm39) missense probably benign 0.12
R6568:Miip UTSW 4 147,950,372 (GRCm39) missense probably benign
R6603:Miip UTSW 4 147,950,380 (GRCm39) missense possibly damaging 0.92
R7639:Miip UTSW 4 147,947,021 (GRCm39) missense probably benign 0.22
R7701:Miip UTSW 4 147,947,371 (GRCm39) missense probably null 0.86
R7795:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7796:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7797:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7872:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R7920:Miip UTSW 4 147,947,375 (GRCm39) missense probably benign 0.17
R8468:Miip UTSW 4 147,945,928 (GRCm39) missense probably damaging 1.00
R8492:Miip UTSW 4 147,945,881 (GRCm39) missense probably damaging 1.00
R8677:Miip UTSW 4 147,947,503 (GRCm39) missense probably damaging 1.00
R8852:Miip UTSW 4 147,950,839 (GRCm39) start gained probably benign
R8860:Miip UTSW 4 147,950,839 (GRCm39) start gained probably benign
R9755:Miip UTSW 4 147,950,319 (GRCm39) nonsense probably null
Posted On 2015-12-18