Incidental Mutation 'IGL02831:Kctd2'
ID361420
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kctd2
Ensembl Gene ENSMUSG00000016940
Gene Namepotassium channel tetramerisation domain containing 2
Synonyms2310012I15Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.421) question?
Stock #IGL02831
Quality Score
Status
Chromosome11
Chromosomal Location115420128-115431274 bp(+) (GRCm38)
Type of Mutationmakesense
DNA Base Change (assembly) T to A at 115430340 bp
ZygosityHeterozygous
Amino Acid Change Stop codon to Lysine at position 264 (*264K)
Ref Sequence ENSEMBL: ENSMUSP00000099324 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103035] [ENSMUST00000106533]
Predicted Effect probably null
Transcript: ENSMUST00000103035
AA Change: *264K
SMART Domains Protein: ENSMUSP00000099324
Gene: ENSMUSG00000016940
AA Change: *264K

DomainStartEndE-ValueType
low complexity region 8 43 N/A INTRINSIC
low complexity region 46 71 N/A INTRINSIC
BTB 72 175 3.45e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106533
SMART Domains Protein: ENSMUSP00000102143
Gene: ENSMUSG00000016940

DomainStartEndE-ValueType
low complexity region 8 43 N/A INTRINSIC
low complexity region 46 71 N/A INTRINSIC
BTB 72 175 3.45e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123345
SMART Domains Protein: ENSMUSP00000115862
Gene: ENSMUSG00000016940

DomainStartEndE-ValueType
low complexity region 4 39 N/A INTRINSIC
low complexity region 42 67 N/A INTRINSIC
BTB 68 171 3.45e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143775
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a C T 11: 110,053,081 V1121M probably damaging Het
Acrbp C A 6: 125,061,249 T471N possibly damaging Het
Blnk C T 19: 40,962,429 D93N probably damaging Het
Casp7 A G 19: 56,404,423 D3G probably benign Het
Cd163l1 G T 7: 140,228,521 V782L probably benign Het
Coro1c A T 5: 113,844,408 C456S probably benign Het
Dlec1 T G 9: 119,143,915 L1499R probably damaging Het
Dnah8 T C 17: 30,712,276 S1422P probably benign Het
Exd1 T C 2: 119,528,754 D216G probably damaging Het
Fhit T C 14: 9,870,080 T130A probably benign Het
Frem1 A T 4: 82,956,158 M1409K probably benign Het
Fut2 C T 7: 45,650,769 G193E possibly damaging Het
Glb1l2 A G 9: 26,767,450 V465A probably benign Het
Ints8 T C 4: 11,245,896 Q194R possibly damaging Het
Ip6k2 C T 9: 108,804,534 probably benign Het
Krt34 C A 11: 100,040,147 probably benign Het
Lamc1 A G 1: 153,247,055 S760P probably benign Het
Lrp1b T C 2: 41,193,591 N1702S probably damaging Het
Lrrc8e T A 8: 4,235,429 S551R probably damaging Het
Map3k20 T C 2: 72,371,727 V139A probably damaging Het
Mkl1 A G 15: 81,104,793 L9P probably benign Het
Napsa A G 7: 44,586,760 T408A probably benign Het
Olfr1156 T C 2: 87,949,676 probably null Het
Olfr132 T C 17: 38,130,512 K227E probably benign Het
Olfr1361 T C 13: 21,658,904 I140V probably benign Het
Panx1 A G 9: 15,007,648 L305P probably damaging Het
Pkhd1l1 A G 15: 44,501,493 H676R probably benign Het
Pld1 T A 3: 28,076,425 V458E probably damaging Het
Ppp5c A G 7: 17,008,645 L256P probably damaging Het
Pyroxd2 G T 19: 42,735,903 T307K probably damaging Het
Sin3b A G 8: 72,744,562 E379G probably damaging Het
Slc22a23 T C 13: 34,299,069 T276A possibly damaging Het
Slc26a3 T C 12: 31,452,629 I283T probably damaging Het
Sltm A G 9: 70,584,865 D712G probably damaging Het
Slu7 C T 11: 43,442,653 Q367* probably null Het
Srbd1 T C 17: 86,003,871 N706S probably damaging Het
Supt16 A T 14: 52,170,878 M870K possibly damaging Het
Tnxb T C 17: 34,703,571 Y2453H possibly damaging Het
Tomm40 A G 7: 19,703,089 Y274H probably damaging Het
Utp20 A T 10: 88,815,908 D404E probably benign Het
Vmn2r23 T A 6: 123,704,385 M84K probably benign Het
Wdr70 A G 15: 7,884,306 Y621H possibly damaging Het
Wfdc8 C T 2: 164,605,765 probably null Het
Other mutations in Kctd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03274:Kctd2 APN 11 115429382 missense possibly damaging 0.68
R0066:Kctd2 UTSW 11 115429517 intron probably benign
R0066:Kctd2 UTSW 11 115429517 intron probably benign
R3888:Kctd2 UTSW 11 115427519 missense probably damaging 1.00
R4393:Kctd2 UTSW 11 115429500 intron probably benign
R4868:Kctd2 UTSW 11 115429379 missense probably damaging 0.99
R7248:Kctd2 UTSW 11 115422019 missense possibly damaging 0.46
R8254:Kctd2 UTSW 11 115420348 missense unknown
R8485:Kctd2 UTSW 11 115429608 intron probably benign
R8527:Kctd2 UTSW 11 115429484 intron probably benign
R8542:Kctd2 UTSW 11 115429484 intron probably benign
R8768:Kctd2 UTSW 11 115420453 missense probably damaging 1.00
Z1088:Kctd2 UTSW 11 115421987 missense possibly damaging 0.93
Posted On2015-12-18