Incidental Mutation 'IGL02831:Or2h15'
ID 361430
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2h15
Ensembl Gene ENSMUSG00000067186
Gene Name olfactory receptor family 2 subfamily H member 15
Synonyms Olfr132, MOR256-49, GA_x6K02T2PSCP-2579687-2578746
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # IGL02831
Quality Score
Chromosome 17
Chromosomal Location 38441140-38442081 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38441403 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 227 (K227E)
Ref Sequence ENSEMBL: ENSMUSP00000149593 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087128] [ENSMUST00000216804]
AlphaFold Q7TRI8
Predicted Effect probably benign
Transcript: ENSMUST00000087128
AA Change: K227E

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000084368
Gene: ENSMUSG00000067186
AA Change: K227E

Pfam:7TM_GPCR_Srv 25 244 3.1e-6 PFAM
Pfam:7tm_4 31 308 4.6e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-7 PFAM
Pfam:7tm_1 41 290 8.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216804
AA Change: K227E

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217361
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a C T 11: 109,943,907 (GRCm39) V1121M probably damaging Het
Acrbp C A 6: 125,038,212 (GRCm39) T471N possibly damaging Het
Blnk C T 19: 40,950,873 (GRCm39) D93N probably damaging Het
Casp7 A G 19: 56,392,855 (GRCm39) D3G probably benign Het
Coro1c A T 5: 113,982,469 (GRCm39) C456S probably benign Het
Dlec1 T G 9: 118,972,983 (GRCm39) L1499R probably damaging Het
Dnah8 T C 17: 30,931,250 (GRCm39) S1422P probably benign Het
Exd1 T C 2: 119,359,235 (GRCm39) D216G probably damaging Het
Fhit T C 14: 9,870,080 (GRCm38) T130A probably benign Het
Frem1 A T 4: 82,874,395 (GRCm39) M1409K probably benign Het
Fut2 C T 7: 45,300,193 (GRCm39) G193E possibly damaging Het
Glb1l2 A G 9: 26,678,746 (GRCm39) V465A probably benign Het
Ints8 T C 4: 11,245,896 (GRCm39) Q194R possibly damaging Het
Ip6k2 C T 9: 108,681,733 (GRCm39) probably benign Het
Kctd2 T A 11: 115,321,166 (GRCm39) *264K probably null Het
Krt34 C A 11: 99,930,973 (GRCm39) probably benign Het
Lamc1 A G 1: 153,122,801 (GRCm39) S760P probably benign Het
Lrp1b T C 2: 41,083,603 (GRCm39) N1702S probably damaging Het
Lrrc8e T A 8: 4,285,429 (GRCm39) S551R probably damaging Het
Map3k20 T C 2: 72,202,071 (GRCm39) V139A probably damaging Het
Mrtfa A G 15: 80,988,994 (GRCm39) L9P probably benign Het
Napsa A G 7: 44,236,184 (GRCm39) T408A probably benign Het
Or2w6 T C 13: 21,843,074 (GRCm39) I140V probably benign Het
Or5l13 T C 2: 87,780,020 (GRCm39) probably null Het
Panx1 A G 9: 14,918,944 (GRCm39) L305P probably damaging Het
Pkhd1l1 A G 15: 44,364,889 (GRCm39) H676R probably benign Het
Pld1 T A 3: 28,130,574 (GRCm39) V458E probably damaging Het
Ppp5c A G 7: 16,742,570 (GRCm39) L256P probably damaging Het
Pyroxd2 G T 19: 42,724,342 (GRCm39) T307K probably damaging Het
Scart1 G T 7: 139,808,434 (GRCm39) V782L probably benign Het
Sin3b A G 8: 73,471,190 (GRCm39) E379G probably damaging Het
Slc22a23 T C 13: 34,483,052 (GRCm39) T276A possibly damaging Het
Slc26a3 T C 12: 31,502,628 (GRCm39) I283T probably damaging Het
Sltm A G 9: 70,492,147 (GRCm39) D712G probably damaging Het
Slu7 C T 11: 43,333,480 (GRCm39) Q367* probably null Het
Srbd1 T C 17: 86,311,299 (GRCm39) N706S probably damaging Het
Supt16 A T 14: 52,408,335 (GRCm39) M870K possibly damaging Het
Tnxb T C 17: 34,922,545 (GRCm39) Y2453H possibly damaging Het
Tomm40 A G 7: 19,437,014 (GRCm39) Y274H probably damaging Het
Utp20 A T 10: 88,651,770 (GRCm39) D404E probably benign Het
Vmn2r23 T A 6: 123,681,344 (GRCm39) M84K probably benign Het
Wdr70 A G 15: 7,913,787 (GRCm39) Y621H possibly damaging Het
Wfdc8 C T 2: 164,447,685 (GRCm39) probably null Het
Other mutations in Or2h15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02276:Or2h15 APN 17 38,441,484 (GRCm39) missense probably damaging 0.97
IGL02659:Or2h15 APN 17 38,441,427 (GRCm39) missense possibly damaging 0.78
R0070:Or2h15 UTSW 17 38,441,780 (GRCm39) missense probably damaging 1.00
R0070:Or2h15 UTSW 17 38,441,780 (GRCm39) missense probably damaging 1.00
R1162:Or2h15 UTSW 17 38,441,984 (GRCm39) missense possibly damaging 0.69
R2697:Or2h15 UTSW 17 38,441,900 (GRCm39) missense probably damaging 0.99
R4694:Or2h15 UTSW 17 38,441,748 (GRCm39) missense probably damaging 1.00
R4883:Or2h15 UTSW 17 38,441,508 (GRCm39) missense probably damaging 1.00
R4933:Or2h15 UTSW 17 38,441,441 (GRCm39) missense probably damaging 1.00
R4982:Or2h15 UTSW 17 38,441,468 (GRCm39) missense probably damaging 0.99
R5058:Or2h15 UTSW 17 38,441,432 (GRCm39) missense probably damaging 1.00
R5653:Or2h15 UTSW 17 38,442,075 (GRCm39) missense possibly damaging 0.63
R5946:Or2h15 UTSW 17 38,441,598 (GRCm39) missense probably benign 0.07
R7083:Or2h15 UTSW 17 38,441,601 (GRCm39) missense probably benign
R7226:Or2h15 UTSW 17 38,441,324 (GRCm39) missense probably benign 0.01
R7391:Or2h15 UTSW 17 38,441,941 (GRCm39) missense probably benign
R8297:Or2h15 UTSW 17 38,441,484 (GRCm39) missense probably damaging 0.97
R8378:Or2h15 UTSW 17 38,441,678 (GRCm39) missense probably benign 0.05
R8425:Or2h15 UTSW 17 38,441,927 (GRCm39) missense possibly damaging 0.83
R8554:Or2h15 UTSW 17 38,441,489 (GRCm39) missense probably damaging 1.00
R9223:Or2h15 UTSW 17 38,442,012 (GRCm39) missense possibly damaging 0.66
R9278:Or2h15 UTSW 17 38,441,693 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18