Incidental Mutation 'IGL02831:Olfr132'
ID361430
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr132
Ensembl Gene ENSMUSG00000067186
Gene Nameolfactory receptor 132
SynonymsGA_x6K02T2PSCP-2579687-2578746, MOR256-49
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL02831
Quality Score
Status
Chromosome17
Chromosomal Location38129863-38134526 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 38130512 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 227 (K227E)
Ref Sequence ENSEMBL: ENSMUSP00000149593 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087128] [ENSMUST00000216804]
Predicted Effect probably benign
Transcript: ENSMUST00000087128
AA Change: K227E

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000084368
Gene: ENSMUSG00000067186
AA Change: K227E

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 25 244 3.1e-6 PFAM
Pfam:7tm_4 31 308 4.6e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-7 PFAM
Pfam:7tm_1 41 290 8.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216804
AA Change: K227E

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217361
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a C T 11: 110,053,081 V1121M probably damaging Het
Acrbp C A 6: 125,061,249 T471N possibly damaging Het
Blnk C T 19: 40,962,429 D93N probably damaging Het
Casp7 A G 19: 56,404,423 D3G probably benign Het
Cd163l1 G T 7: 140,228,521 V782L probably benign Het
Coro1c A T 5: 113,844,408 C456S probably benign Het
Dlec1 T G 9: 119,143,915 L1499R probably damaging Het
Dnah8 T C 17: 30,712,276 S1422P probably benign Het
Exd1 T C 2: 119,528,754 D216G probably damaging Het
Fhit T C 14: 9,870,080 T130A probably benign Het
Frem1 A T 4: 82,956,158 M1409K probably benign Het
Fut2 C T 7: 45,650,769 G193E possibly damaging Het
Glb1l2 A G 9: 26,767,450 V465A probably benign Het
Ints8 T C 4: 11,245,896 Q194R possibly damaging Het
Ip6k2 C T 9: 108,804,534 probably benign Het
Kctd2 T A 11: 115,430,340 *264K probably null Het
Krt34 C A 11: 100,040,147 probably benign Het
Lamc1 A G 1: 153,247,055 S760P probably benign Het
Lrp1b T C 2: 41,193,591 N1702S probably damaging Het
Lrrc8e T A 8: 4,235,429 S551R probably damaging Het
Map3k20 T C 2: 72,371,727 V139A probably damaging Het
Mkl1 A G 15: 81,104,793 L9P probably benign Het
Napsa A G 7: 44,586,760 T408A probably benign Het
Olfr1156 T C 2: 87,949,676 probably null Het
Olfr1361 T C 13: 21,658,904 I140V probably benign Het
Panx1 A G 9: 15,007,648 L305P probably damaging Het
Pkhd1l1 A G 15: 44,501,493 H676R probably benign Het
Pld1 T A 3: 28,076,425 V458E probably damaging Het
Ppp5c A G 7: 17,008,645 L256P probably damaging Het
Pyroxd2 G T 19: 42,735,903 T307K probably damaging Het
Sin3b A G 8: 72,744,562 E379G probably damaging Het
Slc22a23 T C 13: 34,299,069 T276A possibly damaging Het
Slc26a3 T C 12: 31,452,629 I283T probably damaging Het
Sltm A G 9: 70,584,865 D712G probably damaging Het
Slu7 C T 11: 43,442,653 Q367* probably null Het
Srbd1 T C 17: 86,003,871 N706S probably damaging Het
Supt16 A T 14: 52,170,878 M870K possibly damaging Het
Tnxb T C 17: 34,703,571 Y2453H possibly damaging Het
Tomm40 A G 7: 19,703,089 Y274H probably damaging Het
Utp20 A T 10: 88,815,908 D404E probably benign Het
Vmn2r23 T A 6: 123,704,385 M84K probably benign Het
Wdr70 A G 15: 7,884,306 Y621H possibly damaging Het
Wfdc8 C T 2: 164,605,765 probably null Het
Other mutations in Olfr132
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02276:Olfr132 APN 17 38130593 missense probably damaging 0.97
IGL02659:Olfr132 APN 17 38130536 missense possibly damaging 0.78
R0070:Olfr132 UTSW 17 38130889 missense probably damaging 1.00
R0070:Olfr132 UTSW 17 38130889 missense probably damaging 1.00
R1162:Olfr132 UTSW 17 38131093 missense possibly damaging 0.69
R2697:Olfr132 UTSW 17 38131009 missense probably damaging 0.99
R4694:Olfr132 UTSW 17 38130857 missense probably damaging 1.00
R4883:Olfr132 UTSW 17 38130617 missense probably damaging 1.00
R4933:Olfr132 UTSW 17 38130550 missense probably damaging 1.00
R4982:Olfr132 UTSW 17 38130577 missense probably damaging 0.99
R5058:Olfr132 UTSW 17 38130541 missense probably damaging 1.00
R5653:Olfr132 UTSW 17 38131184 missense possibly damaging 0.63
R5946:Olfr132 UTSW 17 38130707 missense probably benign 0.07
R7083:Olfr132 UTSW 17 38130710 missense probably benign
R7226:Olfr132 UTSW 17 38130433 missense probably benign 0.01
R7391:Olfr132 UTSW 17 38131050 missense probably benign
R8297:Olfr132 UTSW 17 38130593 missense probably damaging 0.97
R8378:Olfr132 UTSW 17 38130787 missense probably benign 0.05
R8425:Olfr132 UTSW 17 38131036 missense possibly damaging 0.83
R8554:Olfr132 UTSW 17 38130598 missense probably damaging 1.00
Posted On2015-12-18