Incidental Mutation 'IGL02831:Sltm'
ID 361440
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sltm
Ensembl Gene ENSMUSG00000032212
Gene Name SAFB-like, transcription modulator
Synonyms 5730455C01Rik, 5730555F13Rik, 9130215G10Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.958) question?
Stock # IGL02831
Quality Score
Status
Chromosome 9
Chromosomal Location 70450036-70499516 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 70492147 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 712 (D712G)
Ref Sequence ENSEMBL: ENSMUSP00000149059 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049263] [ENSMUST00000216816] [ENSMUST00000217593]
AlphaFold Q8CH25
Predicted Effect probably damaging
Transcript: ENSMUST00000049263
AA Change: D730G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049112
Gene: ENSMUSG00000032212
AA Change: D730G

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
SAP 22 56 2.49e-10 SMART
low complexity region 74 86 N/A INTRINSIC
coiled coil region 152 180 N/A INTRINSIC
low complexity region 318 330 N/A INTRINSIC
low complexity region 352 384 N/A INTRINSIC
RRM 385 458 2.06e-16 SMART
low complexity region 498 526 N/A INTRINSIC
low complexity region 536 552 N/A INTRINSIC
low complexity region 591 601 N/A INTRINSIC
coiled coil region 635 727 N/A INTRINSIC
low complexity region 824 853 N/A INTRINSIC
low complexity region 979 990 N/A INTRINSIC
low complexity region 1015 1028 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214834
Predicted Effect probably damaging
Transcript: ENSMUST00000216816
AA Change: D712G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216881
Predicted Effect probably benign
Transcript: ENSMUST00000217593
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a C T 11: 109,943,907 (GRCm39) V1121M probably damaging Het
Acrbp C A 6: 125,038,212 (GRCm39) T471N possibly damaging Het
Blnk C T 19: 40,950,873 (GRCm39) D93N probably damaging Het
Casp7 A G 19: 56,392,855 (GRCm39) D3G probably benign Het
Coro1c A T 5: 113,982,469 (GRCm39) C456S probably benign Het
Dlec1 T G 9: 118,972,983 (GRCm39) L1499R probably damaging Het
Dnah8 T C 17: 30,931,250 (GRCm39) S1422P probably benign Het
Exd1 T C 2: 119,359,235 (GRCm39) D216G probably damaging Het
Fhit T C 14: 9,870,080 (GRCm38) T130A probably benign Het
Frem1 A T 4: 82,874,395 (GRCm39) M1409K probably benign Het
Fut2 C T 7: 45,300,193 (GRCm39) G193E possibly damaging Het
Glb1l2 A G 9: 26,678,746 (GRCm39) V465A probably benign Het
Ints8 T C 4: 11,245,896 (GRCm39) Q194R possibly damaging Het
Ip6k2 C T 9: 108,681,733 (GRCm39) probably benign Het
Kctd2 T A 11: 115,321,166 (GRCm39) *264K probably null Het
Krt34 C A 11: 99,930,973 (GRCm39) probably benign Het
Lamc1 A G 1: 153,122,801 (GRCm39) S760P probably benign Het
Lrp1b T C 2: 41,083,603 (GRCm39) N1702S probably damaging Het
Lrrc8e T A 8: 4,285,429 (GRCm39) S551R probably damaging Het
Map3k20 T C 2: 72,202,071 (GRCm39) V139A probably damaging Het
Mrtfa A G 15: 80,988,994 (GRCm39) L9P probably benign Het
Napsa A G 7: 44,236,184 (GRCm39) T408A probably benign Het
Or2h15 T C 17: 38,441,403 (GRCm39) K227E probably benign Het
Or2w6 T C 13: 21,843,074 (GRCm39) I140V probably benign Het
Or5l13 T C 2: 87,780,020 (GRCm39) probably null Het
Panx1 A G 9: 14,918,944 (GRCm39) L305P probably damaging Het
Pkhd1l1 A G 15: 44,364,889 (GRCm39) H676R probably benign Het
Pld1 T A 3: 28,130,574 (GRCm39) V458E probably damaging Het
Ppp5c A G 7: 16,742,570 (GRCm39) L256P probably damaging Het
Pyroxd2 G T 19: 42,724,342 (GRCm39) T307K probably damaging Het
Scart1 G T 7: 139,808,434 (GRCm39) V782L probably benign Het
Sin3b A G 8: 73,471,190 (GRCm39) E379G probably damaging Het
Slc22a23 T C 13: 34,483,052 (GRCm39) T276A possibly damaging Het
Slc26a3 T C 12: 31,502,628 (GRCm39) I283T probably damaging Het
Slu7 C T 11: 43,333,480 (GRCm39) Q367* probably null Het
Srbd1 T C 17: 86,311,299 (GRCm39) N706S probably damaging Het
Supt16 A T 14: 52,408,335 (GRCm39) M870K possibly damaging Het
Tnxb T C 17: 34,922,545 (GRCm39) Y2453H possibly damaging Het
Tomm40 A G 7: 19,437,014 (GRCm39) Y274H probably damaging Het
Utp20 A T 10: 88,651,770 (GRCm39) D404E probably benign Het
Vmn2r23 T A 6: 123,681,344 (GRCm39) M84K probably benign Het
Wdr70 A G 15: 7,913,787 (GRCm39) Y621H possibly damaging Het
Wfdc8 C T 2: 164,447,685 (GRCm39) probably null Het
Other mutations in Sltm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00577:Sltm APN 9 70,486,624 (GRCm39) missense probably damaging 1.00
IGL01755:Sltm APN 9 70,491,204 (GRCm39) splice site probably null
IGL01782:Sltm APN 9 70,480,923 (GRCm39) missense probably damaging 1.00
IGL02441:Sltm APN 9 70,494,467 (GRCm39) missense probably damaging 1.00
IGL02947:Sltm APN 9 70,498,946 (GRCm39) missense probably benign 0.05
IGL03166:Sltm APN 9 70,450,251 (GRCm39) missense possibly damaging 0.87
R0288:Sltm UTSW 9 70,486,633 (GRCm39) missense probably damaging 1.00
R0555:Sltm UTSW 9 70,493,363 (GRCm39) missense probably damaging 1.00
R0815:Sltm UTSW 9 70,469,190 (GRCm39) missense probably benign 0.04
R0863:Sltm UTSW 9 70,469,190 (GRCm39) missense probably benign 0.04
R1315:Sltm UTSW 9 70,450,347 (GRCm39) missense probably benign 0.13
R1533:Sltm UTSW 9 70,493,948 (GRCm39) missense probably damaging 1.00
R1676:Sltm UTSW 9 70,480,929 (GRCm39) missense probably damaging 1.00
R1764:Sltm UTSW 9 70,469,082 (GRCm39) missense probably benign 0.00
R1845:Sltm UTSW 9 70,450,314 (GRCm39) missense possibly damaging 0.60
R2049:Sltm UTSW 9 70,488,583 (GRCm39) missense probably benign 0.00
R2163:Sltm UTSW 9 70,498,964 (GRCm39) missense probably damaging 0.99
R3410:Sltm UTSW 9 70,493,240 (GRCm39) missense probably damaging 0.97
R4323:Sltm UTSW 9 70,487,529 (GRCm39) missense probably benign
R4632:Sltm UTSW 9 70,486,651 (GRCm39) missense possibly damaging 0.86
R4748:Sltm UTSW 9 70,488,647 (GRCm39) missense probably damaging 1.00
R4756:Sltm UTSW 9 70,498,892 (GRCm39) missense possibly damaging 0.57
R4782:Sltm UTSW 9 70,496,339 (GRCm39) missense probably damaging 1.00
R4799:Sltm UTSW 9 70,496,339 (GRCm39) missense probably damaging 1.00
R4887:Sltm UTSW 9 70,496,260 (GRCm39) missense probably damaging 1.00
R5221:Sltm UTSW 9 70,486,685 (GRCm39) missense probably damaging 1.00
R5263:Sltm UTSW 9 70,492,081 (GRCm39) missense unknown
R5982:Sltm UTSW 9 70,494,086 (GRCm39) missense probably damaging 1.00
R6297:Sltm UTSW 9 70,488,641 (GRCm39) missense probably damaging 0.99
R6456:Sltm UTSW 9 70,450,269 (GRCm39) missense probably damaging 1.00
R6658:Sltm UTSW 9 70,488,644 (GRCm39) missense probably damaging 1.00
R6720:Sltm UTSW 9 70,480,992 (GRCm39) missense probably damaging 1.00
R6770:Sltm UTSW 9 70,492,059 (GRCm39) missense unknown
R6923:Sltm UTSW 9 70,481,892 (GRCm39) missense probably damaging 1.00
R7051:Sltm UTSW 9 70,466,348 (GRCm39) missense probably damaging 1.00
R7166:Sltm UTSW 9 70,492,132 (GRCm39) missense probably damaging 1.00
R7257:Sltm UTSW 9 70,451,247 (GRCm39) splice site probably null
R7400:Sltm UTSW 9 70,493,352 (GRCm39) missense probably damaging 1.00
R7438:Sltm UTSW 9 70,480,748 (GRCm39) missense unknown
R7484:Sltm UTSW 9 70,481,179 (GRCm39) missense unknown
R7630:Sltm UTSW 9 70,493,955 (GRCm39) missense possibly damaging 0.94
R7631:Sltm UTSW 9 70,493,955 (GRCm39) missense possibly damaging 0.94
R7632:Sltm UTSW 9 70,493,955 (GRCm39) missense possibly damaging 0.94
R7633:Sltm UTSW 9 70,493,955 (GRCm39) missense possibly damaging 0.94
R7862:Sltm UTSW 9 70,479,446 (GRCm39) nonsense probably null
R7885:Sltm UTSW 9 70,493,955 (GRCm39) missense possibly damaging 0.94
R7886:Sltm UTSW 9 70,493,955 (GRCm39) missense possibly damaging 0.94
R7888:Sltm UTSW 9 70,493,955 (GRCm39) missense possibly damaging 0.94
R7889:Sltm UTSW 9 70,493,955 (GRCm39) missense possibly damaging 0.94
R7891:Sltm UTSW 9 70,493,955 (GRCm39) missense possibly damaging 0.94
R7915:Sltm UTSW 9 70,494,431 (GRCm39) missense probably damaging 1.00
R8030:Sltm UTSW 9 70,493,261 (GRCm39) nonsense probably null
R8062:Sltm UTSW 9 70,480,779 (GRCm39) missense unknown
R8099:Sltm UTSW 9 70,493,360 (GRCm39) missense probably damaging 1.00
R8374:Sltm UTSW 9 70,469,227 (GRCm39) missense probably null
R8698:Sltm UTSW 9 70,494,352 (GRCm39) missense probably benign 0.27
R9541:Sltm UTSW 9 70,481,057 (GRCm39) missense unknown
R9563:Sltm UTSW 9 70,480,841 (GRCm39) missense unknown
Posted On 2015-12-18