Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02831:Olfr1156'

361454

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr1156

Ensembl Gene

ENSMUSG00000075144

Gene Name

olfactory receptor 1156

Synonyms

MOR174-3, GA_x6K02T2Q125-49433499-49432537

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

IGL02831

Quality Score

Status

Chromosome

Chromosomal Location

87947053-87953100 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 87949676 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149428 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099842] [ENSMUST00000215903] [ENSMUST00000216191] [ENSMUST00000216726]

Predicted Effect

probably benign
Transcript: ENSMUST00000099842
AA Change: S186G

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000097430
Gene: ENSMUSG00000075144
AA Change: S186G

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.2e-47	PFAM
Pfam:7tm_1	41	290	1.4e-16	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000215903

Predicted Effect

probably benign
Transcript: ENSMUST00000216191
AA Change: S186G

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

Predicted Effect

probably benign
Transcript: ENSMUST00000216726
AA Change: S186G

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8a	C	T	11: 110,053,081	V1121M	probably damaging	Het
Acrbp	C	A	6: 125,061,249	T471N	possibly damaging	Het
Blnk	C	T	19: 40,962,429	D93N	probably damaging	Het
Casp7	A	G	19: 56,404,423	D3G	probably benign	Het
Cd163l1	G	T	7: 140,228,521	V782L	probably benign	Het
Coro1c	A	T	5: 113,844,408	C456S	probably benign	Het
Dlec1	T	G	9: 119,143,915	L1499R	probably damaging	Het
Dnah8	T	C	17: 30,712,276	S1422P	probably benign	Het
Exd1	T	C	2: 119,528,754	D216G	probably damaging	Het
Fhit	T	C	14: 9,870,080	T130A	probably benign	Het
Frem1	A	T	4: 82,956,158	M1409K	probably benign	Het
Fut2	C	T	7: 45,650,769	G193E	possibly damaging	Het
Glb1l2	A	G	9: 26,767,450	V465A	probably benign	Het
Ints8	T	C	4: 11,245,896	Q194R	possibly damaging	Het
Ip6k2	C	T	9: 108,804,534		probably benign	Het
Kctd2	T	A	11: 115,430,340	*264K	probably null	Het
Krt34	C	A	11: 100,040,147		probably benign	Het
Lamc1	A	G	1: 153,247,055	S760P	probably benign	Het
Lrp1b	T	C	2: 41,193,591	N1702S	probably damaging	Het
Lrrc8e	T	A	8: 4,235,429	S551R	probably damaging	Het
Map3k20	T	C	2: 72,371,727	V139A	probably damaging	Het
Mkl1	A	G	15: 81,104,793	L9P	probably benign	Het
Napsa	A	G	7: 44,586,760	T408A	probably benign	Het
Olfr132	T	C	17: 38,130,512	K227E	probably benign	Het
Olfr1361	T	C	13: 21,658,904	I140V	probably benign	Het
Panx1	A	G	9: 15,007,648	L305P	probably damaging	Het
Pkhd1l1	A	G	15: 44,501,493	H676R	probably benign	Het
Pld1	T	A	3: 28,076,425	V458E	probably damaging	Het
Ppp5c	A	G	7: 17,008,645	L256P	probably damaging	Het
Pyroxd2	G	T	19: 42,735,903	T307K	probably damaging	Het
Sin3b	A	G	8: 72,744,562	E379G	probably damaging	Het
Slc22a23	T	C	13: 34,299,069	T276A	possibly damaging	Het
Slc26a3	T	C	12: 31,452,629	I283T	probably damaging	Het
Sltm	A	G	9: 70,584,865	D712G	probably damaging	Het
Slu7	C	T	11: 43,442,653	Q367*	probably null	Het
Srbd1	T	C	17: 86,003,871	N706S	probably damaging	Het
Supt16	A	T	14: 52,170,878	M870K	possibly damaging	Het
Tnxb	T	C	17: 34,703,571	Y2453H	possibly damaging	Het
Tomm40	A	G	7: 19,703,089	Y274H	probably damaging	Het
Utp20	A	T	10: 88,815,908	D404E	probably benign	Het
Vmn2r23	T	A	6: 123,704,385	M84K	probably benign	Het
Wdr70	A	G	15: 7,884,306	Y621H	possibly damaging	Het
Wfdc8	C	T	2: 164,605,765		probably null	Het

Other mutations in Olfr1156

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01396:Olfr1156	APN	2	87949863	missense	probably damaging	0.99
IGL03214:Olfr1156	APN	2	87950071	missense	probably benign	0.16
R0285:Olfr1156	UTSW	2	87950131	missense	probably damaging	0.98
R0926:Olfr1156	UTSW	2	87949922	missense	probably damaging	1.00
R0987:Olfr1156	UTSW	2	87949547	missense	probably benign	0.12
R1422:Olfr1156	UTSW	2	87950095	missense	probably benign	0.00
R1958:Olfr1156	UTSW	2	87949465	missense	probably damaging	1.00
R2239:Olfr1156	UTSW	2	87949397	missense	probably damaging	1.00
R2380:Olfr1156	UTSW	2	87949397	missense	probably damaging	1.00
R3872:Olfr1156	UTSW	2	87949530	missense	probably damaging	1.00
R3873:Olfr1156	UTSW	2	87949530	missense	probably damaging	1.00
R3874:Olfr1156	UTSW	2	87949530	missense	probably damaging	1.00
R4526:Olfr1156	UTSW	2	87949409	missense	probably benign	0.09
R5116:Olfr1156	UTSW	2	87949529	missense	probably benign	0.03
R5985:Olfr1156	UTSW	2	87949321	missense	probably benign	0.02
R5999:Olfr1156	UTSW	2	87949801	splice site	probably null
R6127:Olfr1156	UTSW	2	87949361	missense	probably damaging	1.00
R6259:Olfr1156	UTSW	2	87949435	missense	probably benign	0.20
R6544:Olfr1156	UTSW	2	87949991	missense	probably benign	0.35
R6556:Olfr1156	UTSW	2	87949976	missense	probably benign	0.00
R6715:Olfr1156	UTSW	2	87949991	missense	probably benign	0.35
R6951:Olfr1156	UTSW	2	87949979	missense	possibly damaging	0.79
R7062:Olfr1156	UTSW	2	87950224	missense	probably benign	0.01
R7142:Olfr1156	UTSW	2	87949712	missense	probably benign	0.09
R7749:Olfr1156	UTSW	2	87949478	missense	probably damaging	1.00
R7887:Olfr1156	UTSW	2	87949880	missense	probably damaging	1.00
R8222:Olfr1156	UTSW	2	87949444	missense	probably benign	0.00

Posted On

2015-12-18