Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02832:Vmn2r23'

361462

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02832

Quality Score

Status

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123704396 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 88 (I88V)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

probably benign
Transcript: ENSMUST00000172391
AA Change: I88V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: I88V

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts9	G	A	6: 92,807,175 (GRCm38)	T985M	probably damaging	Het
Alpk1	A	G	3: 127,679,943 (GRCm38)	S804P	possibly damaging	Het
Ap3b1	A	G	13: 94,528,327 (GRCm38)	I925V	unknown	Het
Cep135	T	A	5: 76,640,949 (GRCm38)	S1130T	probably damaging	Het
Cers3	A	T	7: 66,781,825 (GRCm38)	M183L	probably benign	Het
Col5a1	A	G	2: 27,952,340 (GRCm38)	E409G	unknown	Het
Cyp4a32	G	T	4: 115,614,621 (GRCm38)	V410F	probably damaging	Het
Ddx1	G	A	12: 13,227,317 (GRCm38)	Q528*	probably null	Het
Dio2	G	A	12: 90,729,404 (GRCm38)		probably benign	Het
Dnah9	G	T	11: 66,040,346 (GRCm38)	A2008E	probably damaging	Het
Dnajc2	A	G	5: 21,760,410 (GRCm38)	V457A	probably benign	Het
Dytn	T	C	1: 63,643,373 (GRCm38)	T372A	probably benign	Het
Fam135a	T	C	1: 24,028,633 (GRCm38)	I152V	probably benign	Het
Fmnl2	C	T	2: 52,858,249 (GRCm38)	A36V	possibly damaging	Het
Galnt7	G	A	8: 57,552,497 (GRCm38)	T234I	probably damaging	Het
Gba	A	C	3: 89,203,502 (GRCm38)	I6L	probably benign	Het
Gja10	A	G	4: 32,602,147 (GRCm38)	V79A	probably damaging	Het
Gpd2	T	A	2: 57,338,979 (GRCm38)	V265E	probably damaging	Het
Gpld1	T	C	13: 24,952,878 (GRCm38)	Y60H	probably damaging	Het
Heatr9	A	G	11: 83,518,846 (GRCm38)		probably benign	Het
Hist3h2ba	A	G	11: 58,949,043 (GRCm38)	K35R	probably benign	Het
Krt75	T	A	15: 101,568,073 (GRCm38)	D419V	probably benign	Het
Lrig3	A	T	10: 126,007,002 (GRCm38)	I599F	probably benign	Het
Lrp4	A	G	2: 91,511,580 (GRCm38)	D1846G	probably damaging	Het
Mamdc2	C	T	19: 23,303,851 (GRCm38)	A653T	probably damaging	Het
Myo7a	A	T	7: 98,091,020 (GRCm38)		probably null	Het
Notch2	A	G	3: 98,137,373 (GRCm38)	D1537G	probably benign	Het
Olfr370	G	A	8: 83,541,471 (GRCm38)	C109Y	probably damaging	Het
Olfr559	G	T	7: 102,723,651 (GRCm38)	H280N	probably benign	Het
Olfr608	A	T	7: 103,470,698 (GRCm38)	I220L	probably benign	Het
Papss1	A	C	3: 131,582,519 (GRCm38)	D84A	probably damaging	Het
Pcdhb16	T	A	18: 37,478,474 (GRCm38)	D162E	probably damaging	Het
Rab11fip1	C	T	8: 27,152,812 (GRCm38)	R653Q	possibly damaging	Het
Rap1gap2	A	T	11: 74,412,455 (GRCm38)		probably benign	Het
Rasal2	T	C	1: 157,157,207 (GRCm38)	D990G	probably damaging	Het
Rnf32	T	C	5: 29,205,703 (GRCm38)		probably null	Het
Rp1	T	C	1: 4,349,713 (GRCm38)	D392G	probably benign	Het
Scn9a	T	C	2: 66,568,029 (GRCm38)	D79G	probably damaging	Het
Selenon	A	T	4: 134,540,908 (GRCm38)	V438D	probably damaging	Het
Slc47a1	G	A	11: 61,363,413 (GRCm38)	H158Y	probably benign	Het
Slc5a12	A	T	2: 110,640,815 (GRCm38)	E463D	probably benign	Het
Taf2	C	T	15: 55,016,563 (GRCm38)	V1126M	probably benign	Het
Tas2r143	G	T	6: 42,400,325 (GRCm38)	V30L	possibly damaging	Het
Tcea3	G	A	4: 136,268,113 (GRCm38)	V256M	probably damaging	Het
Thy1	A	G	9: 44,046,814 (GRCm38)	T80A	probably benign	Het
Tmem9	A	G	1: 136,019,731 (GRCm38)	N47S	probably damaging	Het
Tmprss11g	T	C	5: 86,497,269 (GRCm38)	Q101R	probably benign	Het
Trim66	C	T	7: 109,460,497 (GRCm38)	C792Y	probably damaging	Het
Tstd2	A	T	4: 46,124,949 (GRCm38)	M226K	probably damaging	Het
Utrn	G	T	10: 12,738,193 (GRCm38)	T378K	possibly damaging	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123,729,725 (GRCm38)	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123,729,596 (GRCm38)	missense	probably benign
IGL01073:Vmn2r23	APN	6	123,712,800 (GRCm38)	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123,704,424 (GRCm38)	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123,704,407 (GRCm38)	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123,741,886 (GRCm38)	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123,741,860 (GRCm38)	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123,741,744 (GRCm38)	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123,741,836 (GRCm38)	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123,704,478 (GRCm38)	missense	probably benign
IGL02831:Vmn2r23	APN	6	123,704,385 (GRCm38)	missense	probably benign	0.22
IGL02865:Vmn2r23	APN	6	123,741,619 (GRCm38)	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123,741,782 (GRCm38)	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123,704,374 (GRCm38)	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123,729,626 (GRCm38)	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123,712,977 (GRCm38)	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123,729,721 (GRCm38)	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123,713,451 (GRCm38)	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123,742,135 (GRCm38)	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123,742,004 (GRCm38)	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123,713,270 (GRCm38)	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123,713,427 (GRCm38)	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123,729,690 (GRCm38)	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123,702,915 (GRCm38)	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123,713,010 (GRCm38)	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123,741,499 (GRCm38)	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123,704,425 (GRCm38)	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123,742,188 (GRCm38)	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123,713,164 (GRCm38)	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123,713,164 (GRCm38)	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123,713,170 (GRCm38)	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123,741,389 (GRCm38)	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123,729,738 (GRCm38)	missense	probably benign
R4506:Vmn2r23	UTSW	6	123,702,925 (GRCm38)	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123,741,730 (GRCm38)	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123,741,826 (GRCm38)	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123,713,074 (GRCm38)	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123,733,349 (GRCm38)	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123,712,977 (GRCm38)	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123,713,002 (GRCm38)	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123,713,451 (GRCm38)	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123,713,074 (GRCm38)	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123,733,273 (GRCm38)	missense	probably benign
R5761:Vmn2r23	UTSW	6	123,712,759 (GRCm38)	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123,733,393 (GRCm38)	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123,712,942 (GRCm38)	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123,741,895 (GRCm38)	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123,704,400 (GRCm38)	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123,712,902 (GRCm38)	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123,713,425 (GRCm38)	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123,733,273 (GRCm38)	missense	probably benign
R6925:Vmn2r23	UTSW	6	123,704,553 (GRCm38)	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123,713,022 (GRCm38)	missense	probably benign
R7215:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123,741,581 (GRCm38)	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123,704,579 (GRCm38)	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123,704,541 (GRCm38)	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123,741,353 (GRCm38)	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123,704,640 (GRCm38)	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123,741,656 (GRCm38)	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123,713,472 (GRCm38)	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123,703,032 (GRCm38)	missense
R8966:Vmn2r23	UTSW	6	123,742,120 (GRCm38)	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123,742,079 (GRCm38)	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123,741,823 (GRCm38)	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123,733,393 (GRCm38)	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123,712,713 (GRCm38)	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123,712,713 (GRCm38)	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123,713,116 (GRCm38)	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123,713,161 (GRCm38)	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123,742,108 (GRCm38)	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123,729,725 (GRCm38)	frame shift	probably null

Posted On

2015-12-18