Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02832:Scn9a'

361474

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scn9a

Ensembl Gene

ENSMUSG00000075316

Gene Name

sodium channel, voltage-gated, type IX, alpha

Synonyms

PN1

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02832

Quality Score

Status

Chromosome

Chromosomal Location

66480080-66634962 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 66568029 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 79 (D79G)

Ref Sequence

ENSEMBL: ENSMUSP00000131711 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100063] [ENSMUST00000100064] [ENSMUST00000112354] [ENSMUST00000164384] [ENSMUST00000169900]

AlphaFold

Q62205

Predicted Effect

probably damaging
Transcript: ENSMUST00000100063
AA Change: D79G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000097641
Gene: ENSMUSG00000075316
AA Change: D79G

Domain	Start	End	E-Value	Type
low complexity region	29	49	N/A	INTRINSIC
Pfam:Ion_trans	154	403	9.5e-78	PFAM
coiled coil region	404	442	N/A	INTRINSIC
Pfam:DUF3451	465	685	1.3e-62	PFAM
Pfam:Ion_trans	768	957	9.9e-48	PFAM
Pfam:Na_trans_assoc	972	1191	2.9e-72	PFAM
low complexity region	1203	1214	N/A	INTRINSIC
Pfam:Ion_trans	1217	1445	2.8e-55	PFAM
PDB:1BYY\|A	1447	1499	9e-27	PDB
Pfam:Ion_trans	1538	1748	3.4e-52	PFAM
Pfam:PKD_channel	1599	1755	1.1e-7	PFAM
IQ	1877	1899	1.03e-3	SMART
low complexity region	1956	1972	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000100064
AA Change: D79G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000097642
Gene: ENSMUSG00000075316
AA Change: D79G

Domain	Start	End	E-Value	Type
low complexity region	29	49	N/A	INTRINSIC
Pfam:Ion_trans	125	412	2.2e-84	PFAM
low complexity region	433	446	N/A	INTRINSIC
Pfam:Na_trans_cytopl	483	693	7.5e-76	PFAM
Pfam:Ion_trans	742	977	4.1e-57	PFAM
Pfam:Na_trans_assoc	981	1185	1.4e-58	PFAM
Pfam:Ion_trans	1189	1466	7e-67	PFAM
Pfam:Ion_trans	1512	1769	1e-55	PFAM
Pfam:PKD_channel	1605	1763	2.6e-7	PFAM
IQ	1886	1908	1.03e-3	SMART
low complexity region	1965	1981	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000112354
AA Change: D79G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000107973
Gene: ENSMUSG00000075316
AA Change: D79G

Domain	Start	End	E-Value	Type
low complexity region	29	49	N/A	INTRINSIC
Pfam:Ion_trans	154	401	1.2e-77	PFAM
coiled coil region	402	449	N/A	INTRINSIC
Pfam:DUF3451	463	683	1.3e-62	PFAM
Pfam:Ion_trans	766	955	9.9e-48	PFAM
Pfam:Na_trans_assoc	970	1189	2.9e-72	PFAM
low complexity region	1201	1212	N/A	INTRINSIC
Pfam:Ion_trans	1215	1443	2.8e-55	PFAM
PDB:1BYY\|A	1445	1497	7e-29	PDB
Pfam:Ion_trans	1536	1746	3.4e-52	PFAM
Pfam:PKD_channel	1597	1753	1.1e-7	PFAM
IQ	1875	1897	1.03e-3	SMART
low complexity region	1954	1970	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141603

Predicted Effect

probably damaging
Transcript: ENSMUST00000164384
AA Change: D79G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000126528
Gene: ENSMUSG00000075316
AA Change: D79G

Domain	Start	End	E-Value	Type
low complexity region	29	49	N/A	INTRINSIC
Pfam:Ion_trans	154	401	1.1e-77	PFAM
coiled coil region	402	449	N/A	INTRINSIC
Pfam:DUF3451	463	694	4.2e-66	PFAM
Pfam:Ion_trans	777	966	8.8e-48	PFAM
Pfam:Na_trans_assoc	981	1200	6e-72	PFAM
low complexity region	1212	1223	N/A	INTRINSIC
Pfam:Ion_trans	1226	1454	2.5e-55	PFAM
PDB:1BYY\|A	1456	1508	6e-29	PDB
Pfam:Ion_trans	1547	1757	3e-52	PFAM
Pfam:PKD_channel	1608	1764	8.1e-8	PFAM
IQ	1886	1908	1.03e-3	SMART
low complexity region	1965	1981	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000169900
AA Change: D79G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000131711
Gene: ENSMUSG00000075316
AA Change: D79G

Domain	Start	End	E-Value	Type
low complexity region	29	49	N/A	INTRINSIC
Pfam:Ion_trans	154	401	3.7e-78	PFAM
coiled coil region	402	449	N/A	INTRINSIC
Pfam:DUF3451	463	683	1.3e-62	PFAM
Pfam:Ion_trans	766	955	9.9e-48	PFAM
Pfam:Na_trans_assoc	970	1189	2.9e-72	PFAM
low complexity region	1201	1212	N/A	INTRINSIC
Pfam:Ion_trans	1215	1443	2.8e-55	PFAM
PDB:1BYY\|A	1445	1497	7e-29	PDB
Pfam:Ion_trans	1536	1746	3.4e-52	PFAM
Pfam:PKD_channel	1597	1753	1.1e-7	PFAM
IQ	1875	1897	1.03e-3	SMART
low complexity region	1954	1970	N/A	INTRINSIC

Meta Mutation Damage Score

0.2312

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit prenatal/neonatal lethality. Mice homozygous for a knock-in allele exhibit increased susceptibility to electrically induced seizures. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts9	G	A	6: 92,807,175 (GRCm38)	T985M	probably damaging	Het
Alpk1	A	G	3: 127,679,943 (GRCm38)	S804P	possibly damaging	Het
Ap3b1	A	G	13: 94,528,327 (GRCm38)	I925V	unknown	Het
Cep135	T	A	5: 76,640,949 (GRCm38)	S1130T	probably damaging	Het
Cers3	A	T	7: 66,781,825 (GRCm38)	M183L	probably benign	Het
Col5a1	A	G	2: 27,952,340 (GRCm38)	E409G	unknown	Het
Cyp4a32	G	T	4: 115,614,621 (GRCm38)	V410F	probably damaging	Het
Ddx1	G	A	12: 13,227,317 (GRCm38)	Q528*	probably null	Het
Dio2	G	A	12: 90,729,404 (GRCm38)		probably benign	Het
Dnah9	G	T	11: 66,040,346 (GRCm38)	A2008E	probably damaging	Het
Dnajc2	A	G	5: 21,760,410 (GRCm38)	V457A	probably benign	Het
Dytn	T	C	1: 63,643,373 (GRCm38)	T372A	probably benign	Het
Fam135a	T	C	1: 24,028,633 (GRCm38)	I152V	probably benign	Het
Fmnl2	C	T	2: 52,858,249 (GRCm38)	A36V	possibly damaging	Het
Galnt7	G	A	8: 57,552,497 (GRCm38)	T234I	probably damaging	Het
Gba1	A	C	3: 89,203,502 (GRCm38)	I6L	probably benign	Het
Gja10	A	G	4: 32,602,147 (GRCm38)	V79A	probably damaging	Het
Gpd2	T	A	2: 57,338,979 (GRCm38)	V265E	probably damaging	Het
Gpld1	T	C	13: 24,952,878 (GRCm38)	Y60H	probably damaging	Het
Heatr9	A	G	11: 83,518,846 (GRCm38)		probably benign	Het
Hist3h2ba	A	G	11: 58,949,043 (GRCm38)	K35R	probably benign	Het
Krt75	T	A	15: 101,568,073 (GRCm38)	D419V	probably benign	Het
Lrig3	A	T	10: 126,007,002 (GRCm38)	I599F	probably benign	Het
Lrp4	A	G	2: 91,511,580 (GRCm38)	D1846G	probably damaging	Het
Mamdc2	C	T	19: 23,303,851 (GRCm38)	A653T	probably damaging	Het
Myo7a	A	T	7: 98,091,020 (GRCm38)		probably null	Het
Notch2	A	G	3: 98,137,373 (GRCm38)	D1537G	probably benign	Het
Or10k2	G	A	8: 83,541,471 (GRCm38)	C109Y	probably damaging	Het
Or51a25	G	T	7: 102,723,651 (GRCm38)	H280N	probably benign	Het
Or52ae7	A	T	7: 103,470,698 (GRCm38)	I220L	probably benign	Het
Papss1	A	C	3: 131,582,519 (GRCm38)	D84A	probably damaging	Het
Pcdhb16	T	A	18: 37,478,474 (GRCm38)	D162E	probably damaging	Het
Rab11fip1	C	T	8: 27,152,812 (GRCm38)	R653Q	possibly damaging	Het
Rap1gap2	A	T	11: 74,412,455 (GRCm38)		probably benign	Het
Rasal2	T	C	1: 157,157,207 (GRCm38)	D990G	probably damaging	Het
Rnf32	T	C	5: 29,205,703 (GRCm38)		probably null	Het
Rp1	T	C	1: 4,349,713 (GRCm38)	D392G	probably benign	Het
Selenon	A	T	4: 134,540,908 (GRCm38)	V438D	probably damaging	Het
Slc47a1	G	A	11: 61,363,413 (GRCm38)	H158Y	probably benign	Het
Slc5a12	A	T	2: 110,640,815 (GRCm38)	E463D	probably benign	Het
Taf2	C	T	15: 55,016,563 (GRCm38)	V1126M	probably benign	Het
Tas2r143	G	T	6: 42,400,325 (GRCm38)	V30L	possibly damaging	Het
Tcea3	G	A	4: 136,268,113 (GRCm38)	V256M	probably damaging	Het
Thy1	A	G	9: 44,046,814 (GRCm38)	T80A	probably benign	Het
Tmem9	A	G	1: 136,019,731 (GRCm38)	N47S	probably damaging	Het
Tmprss11g	T	C	5: 86,497,269 (GRCm38)	Q101R	probably benign	Het
Trim66	C	T	7: 109,460,497 (GRCm38)	C792Y	probably damaging	Het
Tstd2	A	T	4: 46,124,949 (GRCm38)	M226K	probably damaging	Het
Utrn	G	T	10: 12,738,193 (GRCm38)	T378K	possibly damaging	Het
Vmn2r23	A	G	6: 123,704,396 (GRCm38)	I88V	probably benign	Het

Other mutations in Scn9a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00514:Scn9a	APN	2	66,563,601 (GRCm38)	missense	probably damaging	1.00
IGL00570:Scn9a	APN	2	66,484,142 (GRCm38)	missense	probably damaging	1.00
IGL00809:Scn9a	APN	2	66,483,935 (GRCm38)	missense	probably damaging	1.00
IGL00977:Scn9a	APN	2	66,484,301 (GRCm38)	missense	probably damaging	0.99
IGL01120:Scn9a	APN	2	66,526,972 (GRCm38)	missense	probably benign	0.00
IGL01134:Scn9a	APN	2	66,504,968 (GRCm38)	missense	probably damaging	1.00
IGL01300:Scn9a	APN	2	66,488,053 (GRCm38)	nonsense	probably null
IGL01452:Scn9a	APN	2	66,527,072 (GRCm38)	missense	probably damaging	1.00
IGL01531:Scn9a	APN	2	66,537,378 (GRCm38)	missense	probably benign	0.11
IGL01572:Scn9a	APN	2	66,493,886 (GRCm38)	missense	probably benign	0.00
IGL01645:Scn9a	APN	2	66,487,642 (GRCm38)	missense	possibly damaging	0.62
IGL01823:Scn9a	APN	2	66,484,042 (GRCm38)	missense	probably damaging	1.00
IGL01965:Scn9a	APN	2	66,484,433 (GRCm38)	missense	probably damaging	1.00
IGL02127:Scn9a	APN	2	66,494,826 (GRCm38)	missense	probably damaging	1.00
IGL02127:Scn9a	APN	2	66,547,135 (GRCm38)	missense	probably damaging	1.00
IGL02166:Scn9a	APN	2	66,493,103 (GRCm38)	missense	possibly damaging	0.95
IGL02183:Scn9a	APN	2	66,484,611 (GRCm38)	splice site	probably benign
IGL02640:Scn9a	APN	2	66,536,096 (GRCm38)	critical splice donor site	probably null
IGL02685:Scn9a	APN	2	66,537,293 (GRCm38)	missense	probably damaging	1.00
IGL02798:Scn9a	APN	2	66,540,559 (GRCm38)	missense	possibly damaging	0.52
IGL03008:Scn9a	APN	2	66,562,511 (GRCm38)	missense	probably damaging	1.00
IGL03270:Scn9a	APN	2	66,484,014 (GRCm38)	missense	probably damaging	1.00
IGL03408:Scn9a	APN	2	66,526,747 (GRCm38)	missense	probably benign	0.00
BB007:Scn9a	UTSW	2	66,504,849 (GRCm38)	missense	probably damaging	0.99
BB017:Scn9a	UTSW	2	66,504,849 (GRCm38)	missense	probably damaging	0.99
R0039:Scn9a	UTSW	2	66,562,444 (GRCm38)	missense	probably damaging	0.98
R0173:Scn9a	UTSW	2	66,533,093 (GRCm38)	missense	probably damaging	1.00
R0323:Scn9a	UTSW	2	66,568,131 (GRCm38)	missense	probably damaging	1.00
R0344:Scn9a	UTSW	2	66,505,010 (GRCm38)	missense	probably damaging	0.99
R0421:Scn9a	UTSW	2	66,543,277 (GRCm38)	missense	probably benign
R0465:Scn9a	UTSW	2	66,526,996 (GRCm38)	missense	probably damaging	1.00
R0514:Scn9a	UTSW	2	66,483,678 (GRCm38)	missense	probably damaging	1.00
R0599:Scn9a	UTSW	2	66,526,799 (GRCm38)	missense	probably damaging	0.96
R0627:Scn9a	UTSW	2	66,537,377 (GRCm38)	missense	probably benign	0.00
R0644:Scn9a	UTSW	2	66,533,061 (GRCm38)	critical splice donor site	probably null
R0653:Scn9a	UTSW	2	66,533,377 (GRCm38)	missense	probably damaging	1.00
R0685:Scn9a	UTSW	2	66,483,499 (GRCm38)	missense	probably benign	0.02
R0718:Scn9a	UTSW	2	66,547,112 (GRCm38)	missense	probably damaging	1.00
R0827:Scn9a	UTSW	2	66,536,124 (GRCm38)	nonsense	probably null
R0890:Scn9a	UTSW	2	66,483,735 (GRCm38)	missense	probably damaging	1.00
R1139:Scn9a	UTSW	2	66,504,997 (GRCm38)	missense	probably benign	0.02
R1385:Scn9a	UTSW	2	66,563,542 (GRCm38)	missense	probably damaging	1.00
R1398:Scn9a	UTSW	2	66,484,586 (GRCm38)	missense	probably benign	0.11
R1496:Scn9a	UTSW	2	66,526,888 (GRCm38)	missense	probably benign
R1511:Scn9a	UTSW	2	66,526,813 (GRCm38)	missense	probably benign	0.01
R1517:Scn9a	UTSW	2	66,505,027 (GRCm38)	splice site	probably benign
R1564:Scn9a	UTSW	2	66,484,304 (GRCm38)	missense	probably damaging	1.00
R1634:Scn9a	UTSW	2	66,488,017 (GRCm38)	missense	probably damaging	1.00
R1662:Scn9a	UTSW	2	66,483,459 (GRCm38)	missense	probably benign	0.00
R1695:Scn9a	UTSW	2	66,504,876 (GRCm38)	nonsense	probably null
R1709:Scn9a	UTSW	2	66,483,506 (GRCm38)	missense	probably damaging	1.00
R1741:Scn9a	UTSW	2	66,487,594 (GRCm38)	missense	probably damaging	0.99
R1755:Scn9a	UTSW	2	66,501,716 (GRCm38)	missense	probably benign	0.38
R1914:Scn9a	UTSW	2	66,566,250 (GRCm38)	missense	probably damaging	1.00
R1962:Scn9a	UTSW	2	66,484,311 (GRCm38)	missense	probably damaging	1.00
R1970:Scn9a	UTSW	2	66,515,380 (GRCm38)	missense	probably damaging	0.97
R2017:Scn9a	UTSW	2	66,515,321 (GRCm38)	missense	probably damaging	0.99
R2092:Scn9a	UTSW	2	66,533,376 (GRCm38)	missense	probably damaging	0.99
R2105:Scn9a	UTSW	2	66,568,183 (GRCm38)	missense	probably benign	0.25
R2114:Scn9a	UTSW	2	66,484,052 (GRCm38)	missense	probably damaging	1.00
R2115:Scn9a	UTSW	2	66,484,052 (GRCm38)	missense	probably damaging	1.00
R2128:Scn9a	UTSW	2	66,526,654 (GRCm38)	missense	probably damaging	1.00
R2157:Scn9a	UTSW	2	66,536,325 (GRCm38)	missense	probably damaging	1.00
R2162:Scn9a	UTSW	2	66,534,229 (GRCm38)	missense	probably damaging	0.98
R2350:Scn9a	UTSW	2	66,504,968 (GRCm38)	missense	probably damaging	1.00
R3694:Scn9a	UTSW	2	66,562,405 (GRCm38)	missense	probably benign
R3771:Scn9a	UTSW	2	66,483,648 (GRCm38)	missense	probably benign	0.26
R3772:Scn9a	UTSW	2	66,483,648 (GRCm38)	missense	probably benign	0.26
R3773:Scn9a	UTSW	2	66,483,648 (GRCm38)	missense	probably benign	0.26
R3922:Scn9a	UTSW	2	66,526,873 (GRCm38)	missense	possibly damaging	0.88
R3926:Scn9a	UTSW	2	66,526,873 (GRCm38)	missense	possibly damaging	0.88
R4258:Scn9a	UTSW	2	66,565,054 (GRCm38)	intron	probably benign
R4385:Scn9a	UTSW	2	66,484,556 (GRCm38)	missense	probably damaging	1.00
R4415:Scn9a	UTSW	2	66,526,693 (GRCm38)	missense	probably damaging	1.00
R4570:Scn9a	UTSW	2	66,483,558 (GRCm38)	missense	possibly damaging	0.85
R4682:Scn9a	UTSW	2	66,547,018 (GRCm38)	missense	probably benign
R4783:Scn9a	UTSW	2	66,540,623 (GRCm38)	missense	probably benign	0.01
R4822:Scn9a	UTSW	2	66,483,749 (GRCm38)	missense	possibly damaging	0.55
R4829:Scn9a	UTSW	2	66,551,713 (GRCm38)	missense	probably benign
R4908:Scn9a	UTSW	2	66,526,743 (GRCm38)	missense	probably benign	0.03
R4983:Scn9a	UTSW	2	66,566,270 (GRCm38)	missense	probably benign	0.02
R5047:Scn9a	UTSW	2	66,562,480 (GRCm38)	missense	probably damaging	1.00
R5100:Scn9a	UTSW	2	66,534,119 (GRCm38)	missense	probably damaging	1.00
R5140:Scn9a	UTSW	2	66,565,167 (GRCm38)	missense	possibly damaging	0.81
R5398:Scn9a	UTSW	2	66,488,043 (GRCm38)	missense	probably damaging	1.00
R5557:Scn9a	UTSW	2	66,547,103 (GRCm38)	missense	probably damaging	0.99
R5582:Scn9a	UTSW	2	66,565,029 (GRCm38)	intron	probably benign
R6108:Scn9a	UTSW	2	66,484,049 (GRCm38)	missense	probably damaging	1.00
R6115:Scn9a	UTSW	2	66,563,629 (GRCm38)	missense	possibly damaging	0.70
R6143:Scn9a	UTSW	2	66,487,524 (GRCm38)	missense	probably benign	0.00
R6261:Scn9a	UTSW	2	66,483,896 (GRCm38)	missense	probably damaging	1.00
R6335:Scn9a	UTSW	2	66,568,264 (GRCm38)	start codon destroyed	possibly damaging	0.91
R6429:Scn9a	UTSW	2	66,526,963 (GRCm38)	missense	possibly damaging	0.95
R6632:Scn9a	UTSW	2	66,483,502 (GRCm38)	missense	probably benign	0.23
R6681:Scn9a	UTSW	2	66,563,342 (GRCm38)	missense	possibly damaging	0.90
R6830:Scn9a	UTSW	2	66,568,029 (GRCm38)	missense	probably damaging	1.00
R7102:Scn9a	UTSW	2	66,549,015 (GRCm38)	missense	probably damaging	1.00
R7186:Scn9a	UTSW	2	66,534,223 (GRCm38)	missense	probably damaging	1.00
R7243:Scn9a	UTSW	2	66,540,530 (GRCm38)	missense	probably damaging	1.00
R7311:Scn9a	UTSW	2	66,484,404 (GRCm38)	missense	possibly damaging	0.54
R7328:Scn9a	UTSW	2	66,484,587 (GRCm38)	missense	probably benign
R7386:Scn9a	UTSW	2	66,540,550 (GRCm38)	missense	probably damaging	1.00
R7438:Scn9a	UTSW	2	66,547,187 (GRCm38)	missense	possibly damaging	0.81
R7483:Scn9a	UTSW	2	66,533,348 (GRCm38)	missense	probably damaging	0.99
R7485:Scn9a	UTSW	2	66,534,217 (GRCm38)	missense	probably damaging	1.00
R7526:Scn9a	UTSW	2	66,483,646 (GRCm38)	missense	probably benign
R7617:Scn9a	UTSW	2	66,540,549 (GRCm38)	missense	possibly damaging	0.55
R7642:Scn9a	UTSW	2	66,536,236 (GRCm38)	missense	probably benign	0.02
R7653:Scn9a	UTSW	2	66,527,080 (GRCm38)	missense	probably damaging	1.00
R7747:Scn9a	UTSW	2	66,484,298 (GRCm38)	missense	probably damaging	1.00
R7823:Scn9a	UTSW	2	66,483,791 (GRCm38)	missense	probably damaging	1.00
R7864:Scn9a	UTSW	2	66,484,560 (GRCm38)	missense	possibly damaging	0.73
R7890:Scn9a	UTSW	2	66,543,112 (GRCm38)	missense	probably benign	0.00
R7930:Scn9a	UTSW	2	66,504,849 (GRCm38)	missense	probably damaging	0.99
R7975:Scn9a	UTSW	2	66,484,253 (GRCm38)	missense	probably damaging	1.00
R8057:Scn9a	UTSW	2	66,515,430 (GRCm38)	missense	probably benign	0.06
R8145:Scn9a	UTSW	2	66,487,410 (GRCm38)	missense	probably damaging	1.00
R8163:Scn9a	UTSW	2	66,484,401 (GRCm38)	missense	probably damaging	1.00
R8165:Scn9a	UTSW	2	66,540,530 (GRCm38)	missense	probably damaging	1.00
R8342:Scn9a	UTSW	2	66,536,282 (GRCm38)	missense	probably benign
R8345:Scn9a	UTSW	2	66,494,622 (GRCm38)	missense	probably damaging	0.96
R8464:Scn9a	UTSW	2	66,566,281 (GRCm38)	missense	probably damaging	0.99
R8467:Scn9a	UTSW	2	66,501,671 (GRCm38)	missense	probably damaging	1.00
R8698:Scn9a	UTSW	2	66,536,284 (GRCm38)	missense	probably benign	0.00
R8810:Scn9a	UTSW	2	66,501,666 (GRCm38)	missense	probably damaging	1.00
R8822:Scn9a	UTSW	2	66,540,635 (GRCm38)	missense	probably damaging	0.99
R8829:Scn9a	UTSW	2	66,483,617 (GRCm38)	missense	probably benign
R9009:Scn9a	UTSW	2	66,508,583 (GRCm38)	missense	probably damaging	1.00
R9038:Scn9a	UTSW	2	66,494,803 (GRCm38)	missense	probably damaging	1.00
R9126:Scn9a	UTSW	2	66,484,400 (GRCm38)	missense	probably damaging	1.00
R9205:Scn9a	UTSW	2	66,533,313 (GRCm38)	missense	probably damaging	1.00
R9300:Scn9a	UTSW	2	66,504,892 (GRCm38)	missense	probably benign	0.39
R9373:Scn9a	UTSW	2	66,483,917 (GRCm38)	missense	probably benign	0.00
R9404:Scn9a	UTSW	2	66,526,696 (GRCm38)	missense	probably benign	0.02
R9443:Scn9a	UTSW	2	66,565,209 (GRCm38)	missense	probably damaging	1.00
R9590:Scn9a	UTSW	2	66,483,984 (GRCm38)	missense	probably benign	0.05
R9612:Scn9a	UTSW	2	66,533,364 (GRCm38)	missense	probably damaging	1.00
R9617:Scn9a	UTSW	2	66,562,465 (GRCm38)	missense	probably damaging	1.00
R9717:Scn9a	UTSW	2	66,526,658 (GRCm38)	missense	probably benign
X0003:Scn9a	UTSW	2	66,508,647 (GRCm38)	missense	probably benign	0.02
X0062:Scn9a	UTSW	2	66,568,077 (GRCm38)	missense	probably damaging	1.00
Z1176:Scn9a	UTSW	2	66,540,592 (GRCm38)	missense	probably benign	0.00
Z1177:Scn9a	UTSW	2	66,494,685 (GRCm38)	missense	possibly damaging	0.68

Posted On

2015-12-18