Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02832:Tmprss11g'

361481

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmprss11g

Ensembl Gene

ENSMUSG00000079451

Gene Name

transmembrane protease, serine 11g

Synonyms

Desc4, 9930032O22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL02832

Quality Score

Status

Chromosome

Chromosomal Location

86633736-86666459 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 86645128 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 101 (Q101R)

Ref Sequence

ENSEMBL: ENSMUSP00000115540 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000134179] [ENSMUST00000140095]

AlphaFold

Q8BZ10

Predicted Effect

probably benign
Transcript: ENSMUST00000134179
AA Change: Q101R

PolyPhen 2 Score 0.228 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000122709
Gene: ENSMUSG00000079451
AA Change: Q101R

Domain	Start	End	E-Value	Type
transmembrane domain	21	43	N/A	INTRINSIC
Pfam:SEA	48	150	1.5e-25	PFAM
Tryp_SPc	185	411	1.39e-82	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000140095
AA Change: Q101R

PolyPhen 2 Score 0.228 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000115540
Gene: ENSMUSG00000079451
AA Change: Q101R

Domain	Start	End	E-Value	Type
transmembrane domain	21	43	N/A	INTRINSIC
Pfam:SEA	45	154	1.3e-19	PFAM
Tryp_SPc	172	398	1.39e-82	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts9	G	A	6: 92,784,156 (GRCm39)	T985M	probably damaging	Het
Alpk1	A	G	3: 127,473,592 (GRCm39)	S804P	possibly damaging	Het
Ap3b1	A	G	13: 94,664,835 (GRCm39)	I925V	unknown	Het
Cep135	T	A	5: 76,788,796 (GRCm39)	S1130T	probably damaging	Het
Cers3	A	T	7: 66,431,573 (GRCm39)	M183L	probably benign	Het
Col5a1	A	G	2: 27,842,352 (GRCm39)	E409G	unknown	Het
Cyp4a32	G	T	4: 115,471,818 (GRCm39)	V410F	probably damaging	Het
Ddx1	G	A	12: 13,277,318 (GRCm39)	Q528*	probably null	Het
Dio2	G	A	12: 90,696,178 (GRCm39)		probably benign	Het
Dnah9	G	T	11: 65,931,172 (GRCm39)	A2008E	probably damaging	Het
Dnajc2	A	G	5: 21,965,408 (GRCm39)	V457A	probably benign	Het
Dytn	T	C	1: 63,682,532 (GRCm39)	T372A	probably benign	Het
Fam135a	T	C	1: 24,067,714 (GRCm39)	I152V	probably benign	Het
Fmnl2	C	T	2: 52,748,261 (GRCm39)	A36V	possibly damaging	Het
Galnt7	G	A	8: 58,005,531 (GRCm39)	T234I	probably damaging	Het
Gba1	A	C	3: 89,110,809 (GRCm39)	I6L	probably benign	Het
Gja10	A	G	4: 32,602,147 (GRCm39)	V79A	probably damaging	Het
Gpd2	T	A	2: 57,228,991 (GRCm39)	V265E	probably damaging	Het
Gpld1	T	C	13: 25,136,861 (GRCm39)	Y60H	probably damaging	Het
H2bc27	A	G	11: 58,839,869 (GRCm39)	K35R	probably benign	Het
Heatr9	A	G	11: 83,409,672 (GRCm39)		probably benign	Het
Krt75	T	A	15: 101,476,508 (GRCm39)	D419V	probably benign	Het
Lrig3	A	T	10: 125,842,871 (GRCm39)	I599F	probably benign	Het
Lrp4	A	G	2: 91,341,925 (GRCm39)	D1846G	probably damaging	Het
Mamdc2	C	T	19: 23,281,215 (GRCm39)	A653T	probably damaging	Het
Myo7a	A	T	7: 97,740,227 (GRCm39)		probably null	Het
Notch2	A	G	3: 98,044,689 (GRCm39)	D1537G	probably benign	Het
Or10k2	G	A	8: 84,268,100 (GRCm39)	C109Y	probably damaging	Het
Or51a25	G	T	7: 102,372,858 (GRCm39)	H280N	probably benign	Het
Or52ae7	A	T	7: 103,119,905 (GRCm39)	I220L	probably benign	Het
Papss1	A	C	3: 131,288,280 (GRCm39)	D84A	probably damaging	Het
Pcdhb16	T	A	18: 37,611,527 (GRCm39)	D162E	probably damaging	Het
Rab11fip1	C	T	8: 27,642,840 (GRCm39)	R653Q	possibly damaging	Het
Rap1gap2	A	T	11: 74,303,281 (GRCm39)		probably benign	Het
Rasal2	T	C	1: 156,984,777 (GRCm39)	D990G	probably damaging	Het
Rnf32	T	C	5: 29,410,701 (GRCm39)		probably null	Het
Rp1	T	C	1: 4,419,936 (GRCm39)	D392G	probably benign	Het
Scn9a	T	C	2: 66,398,373 (GRCm39)	D79G	probably damaging	Het
Selenon	A	T	4: 134,268,219 (GRCm39)	V438D	probably damaging	Het
Slc47a1	G	A	11: 61,254,239 (GRCm39)	H158Y	probably benign	Het
Slc5a12	A	T	2: 110,471,160 (GRCm39)	E463D	probably benign	Het
Taf2	C	T	15: 54,879,959 (GRCm39)	V1126M	probably benign	Het
Tas2r143	G	T	6: 42,377,259 (GRCm39)	V30L	possibly damaging	Het
Tcea3	G	A	4: 135,995,424 (GRCm39)	V256M	probably damaging	Het
Thy1	A	G	9: 43,958,111 (GRCm39)	T80A	probably benign	Het
Tmem9	A	G	1: 135,947,469 (GRCm39)	N47S	probably damaging	Het
Trim66	C	T	7: 109,059,704 (GRCm39)	C792Y	probably damaging	Het
Tstd2	A	T	4: 46,124,949 (GRCm39)	M226K	probably damaging	Het
Utrn	G	T	10: 12,613,937 (GRCm39)	T378K	possibly damaging	Het
Vmn2r23	A	G	6: 123,681,355 (GRCm39)	I88V	probably benign	Het

Other mutations in Tmprss11g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00423:Tmprss11g	APN	5	86,640,050 (GRCm39)	missense	probably benign	0.00
IGL01611:Tmprss11g	APN	5	86,638,640 (GRCm39)	missense	probably benign	0.02
IGL02417:Tmprss11g	APN	5	86,638,750 (GRCm39)	missense	probably benign	0.25
IGL02677:Tmprss11g	APN	5	86,640,149 (GRCm39)	missense	probably benign
IGL02887:Tmprss11g	APN	5	86,645,188 (GRCm39)	splice site	probably benign
R0377:Tmprss11g	UTSW	5	86,638,610 (GRCm39)	missense	probably damaging	0.98
R0847:Tmprss11g	UTSW	5	86,638,585 (GRCm39)	missense	probably benign	0.01
R1037:Tmprss11g	UTSW	5	86,638,606 (GRCm39)	missense	probably damaging	1.00
R1507:Tmprss11g	UTSW	5	86,647,470 (GRCm39)	missense	probably benign	0.09
R1617:Tmprss11g	UTSW	5	86,647,422 (GRCm39)	missense	probably damaging	0.99
R1955:Tmprss11g	UTSW	5	86,646,391 (GRCm39)	missense	probably damaging	0.99
R2094:Tmprss11g	UTSW	5	86,647,415 (GRCm39)	missense	probably damaging	1.00
R2906:Tmprss11g	UTSW	5	86,640,661 (GRCm39)	intron	probably benign
R4730:Tmprss11g	UTSW	5	86,637,092 (GRCm39)	missense	probably damaging	1.00
R4730:Tmprss11g	UTSW	5	86,637,091 (GRCm39)	nonsense	probably null
R4934:Tmprss11g	UTSW	5	86,644,401 (GRCm39)	missense	probably benign
R4982:Tmprss11g	UTSW	5	86,640,674 (GRCm39)	missense	probably damaging	1.00
R5086:Tmprss11g	UTSW	5	86,644,377 (GRCm39)	missense	possibly damaging	0.65
R5606:Tmprss11g	UTSW	5	86,635,269 (GRCm39)	missense	probably damaging	1.00
R5825:Tmprss11g	UTSW	5	86,646,392 (GRCm39)	missense	probably damaging	0.98
R6291:Tmprss11g	UTSW	5	86,635,281 (GRCm39)	missense	probably damaging	1.00
R6481:Tmprss11g	UTSW	5	86,640,015 (GRCm39)	missense	probably benign	0.20
R6849:Tmprss11g	UTSW	5	86,644,491 (GRCm39)	missense	probably benign	0.01
R6925:Tmprss11g	UTSW	5	86,635,295 (GRCm39)	missense	probably benign	0.00
R6925:Tmprss11g	UTSW	5	86,635,285 (GRCm39)	missense	probably benign	0.09
R7084:Tmprss11g	UTSW	5	86,640,059 (GRCm39)	missense	probably damaging	1.00
R7089:Tmprss11g	UTSW	5	86,637,150 (GRCm39)	missense	probably damaging	0.97
R7190:Tmprss11g	UTSW	5	86,644,491 (GRCm39)	missense	probably benign	0.18
R7352:Tmprss11g	UTSW	5	86,644,401 (GRCm39)	missense	not run
R7432:Tmprss11g	UTSW	5	86,644,366 (GRCm39)	missense	possibly damaging	0.71
R7514:Tmprss11g	UTSW	5	86,645,176 (GRCm39)	missense	probably damaging	1.00
R8198:Tmprss11g	UTSW	5	86,646,352 (GRCm39)	missense	probably benign
R8490:Tmprss11g	UTSW	5	86,639,976 (GRCm39)	critical splice donor site	probably null
R8495:Tmprss11g	UTSW	5	86,640,119 (GRCm39)	missense	probably benign	0.07
R8706:Tmprss11g	UTSW	5	86,644,404 (GRCm39)	missense	probably damaging	1.00
R8730:Tmprss11g	UTSW	5	86,638,837 (GRCm39)	critical splice acceptor site	probably null
R9158:Tmprss11g	UTSW	5	86,637,166 (GRCm39)	missense	probably damaging	1.00
R9224:Tmprss11g	UTSW	5	86,640,003 (GRCm39)	missense	probably benign

Posted On

2015-12-18