Incidental Mutation 'IGL02832:Olfr559'
ID 361482
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr559
Ensembl Gene ENSMUSG00000066272
Gene Name olfactory receptor 559
Synonyms GA_x6K02T2PBJ9-5441154-5440198, MOR11-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock # IGL02832
Quality Score
Status
Chromosome 7
Chromosomal Location 102723207-102727491 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 102723651 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Histidine to Asparagine at position 280 (H280N)
Ref Sequence ENSEMBL: ENSMUSP00000151100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084816] [ENSMUST00000215657] [ENSMUST00000216312]
AlphaFold Q8VH14
Predicted Effect probably benign
Transcript: ENSMUST00000084816
AA Change: H280N

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000095820
Gene: ENSMUSG00000066272
AA Change: H280N

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 1.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 215 1e-10 PFAM
Pfam:7tm_1 47 299 3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215657
AA Change: H280N

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000216312
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 G A 6: 92,807,175 T985M probably damaging Het
Alpk1 A G 3: 127,679,943 S804P possibly damaging Het
Ap3b1 A G 13: 94,528,327 I925V unknown Het
Cep135 T A 5: 76,640,949 S1130T probably damaging Het
Cers3 A T 7: 66,781,825 M183L probably benign Het
Col5a1 A G 2: 27,952,340 E409G unknown Het
Cyp4a32 G T 4: 115,614,621 V410F probably damaging Het
Ddx1 G A 12: 13,227,317 Q528* probably null Het
Dio2 G A 12: 90,729,404 probably benign Het
Dnah9 G T 11: 66,040,346 A2008E probably damaging Het
Dnajc2 A G 5: 21,760,410 V457A probably benign Het
Dytn T C 1: 63,643,373 T372A probably benign Het
Fam135a T C 1: 24,028,633 I152V probably benign Het
Fmnl2 C T 2: 52,858,249 A36V possibly damaging Het
Galnt7 G A 8: 57,552,497 T234I probably damaging Het
Gba A C 3: 89,203,502 I6L probably benign Het
Gja10 A G 4: 32,602,147 V79A probably damaging Het
Gpd2 T A 2: 57,338,979 V265E probably damaging Het
Gpld1 T C 13: 24,952,878 Y60H probably damaging Het
Heatr9 A G 11: 83,518,846 probably benign Het
Hist3h2ba A G 11: 58,949,043 K35R probably benign Het
Krt75 T A 15: 101,568,073 D419V probably benign Het
Lrig3 A T 10: 126,007,002 I599F probably benign Het
Lrp4 A G 2: 91,511,580 D1846G probably damaging Het
Mamdc2 C T 19: 23,303,851 A653T probably damaging Het
Myo7a A T 7: 98,091,020 probably null Het
Notch2 A G 3: 98,137,373 D1537G probably benign Het
Olfr370 G A 8: 83,541,471 C109Y probably damaging Het
Olfr608 A T 7: 103,470,698 I220L probably benign Het
Papss1 A C 3: 131,582,519 D84A probably damaging Het
Pcdhb16 T A 18: 37,478,474 D162E probably damaging Het
Rab11fip1 C T 8: 27,152,812 R653Q possibly damaging Het
Rap1gap2 A T 11: 74,412,455 probably benign Het
Rasal2 T C 1: 157,157,207 D990G probably damaging Het
Rnf32 T C 5: 29,205,703 probably null Het
Rp1 T C 1: 4,349,713 D392G probably benign Het
Scn9a T C 2: 66,568,029 D79G probably damaging Het
Selenon A T 4: 134,540,908 V438D probably damaging Het
Slc47a1 G A 11: 61,363,413 H158Y probably benign Het
Slc5a12 A T 2: 110,640,815 E463D probably benign Het
Taf2 C T 15: 55,016,563 V1126M probably benign Het
Tas2r143 G T 6: 42,400,325 V30L possibly damaging Het
Tcea3 G A 4: 136,268,113 V256M probably damaging Het
Thy1 A G 9: 44,046,814 T80A probably benign Het
Tmem9 A G 1: 136,019,731 N47S probably damaging Het
Tmprss11g T C 5: 86,497,269 Q101R probably benign Het
Trim66 C T 7: 109,460,497 C792Y probably damaging Het
Tstd2 A T 4: 46,124,949 M226K probably damaging Het
Utrn G T 10: 12,738,193 T378K possibly damaging Het
Vmn2r23 A G 6: 123,704,396 I88V probably benign Het
Other mutations in Olfr559
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0505:Olfr559 UTSW 7 102724029 missense probably damaging 0.97
R1131:Olfr559 UTSW 7 102723680 missense probably damaging 0.99
R1449:Olfr559 UTSW 7 102724190 missense probably damaging 1.00
R3788:Olfr559 UTSW 7 102723487 splice site probably null
R3915:Olfr559 UTSW 7 102724202 missense possibly damaging 0.95
R3980:Olfr559 UTSW 7 102723752 missense probably damaging 0.98
R4647:Olfr559 UTSW 7 102724092 missense probably damaging 1.00
R5242:Olfr559 UTSW 7 102724276 missense probably benign 0.41
R5404:Olfr559 UTSW 7 102723600 missense possibly damaging 0.95
R5464:Olfr559 UTSW 7 102723917 missense possibly damaging 0.85
R5807:Olfr559 UTSW 7 102724202 missense possibly damaging 0.95
R5965:Olfr559 UTSW 7 102724260 missense probably benign 0.00
R6008:Olfr559 UTSW 7 102724367 missense probably damaging 1.00
R6036:Olfr559 UTSW 7 102724485 missense probably benign
R6036:Olfr559 UTSW 7 102724485 missense probably benign
R6493:Olfr559 UTSW 7 102724080 missense possibly damaging 0.85
R6756:Olfr559 UTSW 7 102724088 missense probably benign 0.03
R7201:Olfr559 UTSW 7 102724485 missense probably benign
R7460:Olfr559 UTSW 7 102723821 missense probably benign 0.09
R7695:Olfr559 UTSW 7 102723659 missense probably benign 0.37
R8145:Olfr559 UTSW 7 102723730 missense probably damaging 0.98
R8371:Olfr559 UTSW 7 102723583 missense probably damaging 1.00
R8499:Olfr559 UTSW 7 102723725 missense probably damaging 1.00
R9185:Olfr559 UTSW 7 102724202 missense possibly damaging 0.95
R9230:Olfr559 UTSW 7 102723588 missense possibly damaging 0.95
X0025:Olfr559 UTSW 7 102723815 missense probably damaging 1.00
Posted On 2015-12-18