Incidental Mutation 'IGL02832:Trim66'
ID 361498
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim66
Ensembl Gene ENSMUSG00000031026
Gene Name tripartite motif-containing 66
Synonyms Tif1d, D7H11orf29
Accession Numbers
Essential gene? Probably non essential (E-score: 0.169) question?
Stock # IGL02832
Quality Score
Status
Chromosome 7
Chromosomal Location 109048213-109107341 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 109059704 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 792 (C792Y)
Ref Sequence ENSEMBL: ENSMUSP00000102350 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033339] [ENSMUST00000106739] [ENSMUST00000106741]
AlphaFold Q924W6
Predicted Effect probably damaging
Transcript: ENSMUST00000033339
AA Change: C792Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000033339
Gene: ENSMUSG00000031026
AA Change: C792Y

DomainStartEndE-ValueType
PHD 4 69 7.77e0 SMART
BBC 108 234 1.61e-39 SMART
low complexity region 318 333 N/A INTRINSIC
low complexity region 452 486 N/A INTRINSIC
low complexity region 517 530 N/A INTRINSIC
low complexity region 568 581 N/A INTRINSIC
PHD 998 1041 4.09e-10 SMART
BROMO 1069 1175 8.22e-27 SMART
low complexity region 1185 1199 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000106739
AA Change: C792Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102350
Gene: ENSMUSG00000031026
AA Change: C792Y

DomainStartEndE-ValueType
PHD 4 69 7.77e0 SMART
BBC 108 234 1.61e-39 SMART
low complexity region 318 333 N/A INTRINSIC
low complexity region 452 486 N/A INTRINSIC
low complexity region 517 530 N/A INTRINSIC
low complexity region 568 581 N/A INTRINSIC
PHD 998 1041 4.09e-10 SMART
BROMO 1069 1175 8.22e-27 SMART
low complexity region 1185 1199 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000106741
AA Change: C894Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000102352
Gene: ENSMUSG00000031026
AA Change: C894Y

DomainStartEndE-ValueType
RING 28 78 2.38e-2 SMART
BBOX 102 140 1.48e0 SMART
PHD 106 171 7.77e0 SMART
RING 107 170 4.38e0 SMART
BBOX 162 203 4.21e-3 SMART
BBC 210 336 1.61e-39 SMART
low complexity region 420 435 N/A INTRINSIC
low complexity region 554 588 N/A INTRINSIC
low complexity region 619 632 N/A INTRINSIC
low complexity region 670 683 N/A INTRINSIC
PHD 1100 1143 4.09e-10 SMART
BROMO 1171 1277 8.22e-27 SMART
low complexity region 1287 1301 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 G A 6: 92,784,156 (GRCm39) T985M probably damaging Het
Alpk1 A G 3: 127,473,592 (GRCm39) S804P possibly damaging Het
Ap3b1 A G 13: 94,664,835 (GRCm39) I925V unknown Het
Cep135 T A 5: 76,788,796 (GRCm39) S1130T probably damaging Het
Cers3 A T 7: 66,431,573 (GRCm39) M183L probably benign Het
Col5a1 A G 2: 27,842,352 (GRCm39) E409G unknown Het
Cyp4a32 G T 4: 115,471,818 (GRCm39) V410F probably damaging Het
Ddx1 G A 12: 13,277,318 (GRCm39) Q528* probably null Het
Dio2 G A 12: 90,696,178 (GRCm39) probably benign Het
Dnah9 G T 11: 65,931,172 (GRCm39) A2008E probably damaging Het
Dnajc2 A G 5: 21,965,408 (GRCm39) V457A probably benign Het
Dytn T C 1: 63,682,532 (GRCm39) T372A probably benign Het
Fam135a T C 1: 24,067,714 (GRCm39) I152V probably benign Het
Fmnl2 C T 2: 52,748,261 (GRCm39) A36V possibly damaging Het
Galnt7 G A 8: 58,005,531 (GRCm39) T234I probably damaging Het
Gba1 A C 3: 89,110,809 (GRCm39) I6L probably benign Het
Gja10 A G 4: 32,602,147 (GRCm39) V79A probably damaging Het
Gpd2 T A 2: 57,228,991 (GRCm39) V265E probably damaging Het
Gpld1 T C 13: 25,136,861 (GRCm39) Y60H probably damaging Het
H2bc27 A G 11: 58,839,869 (GRCm39) K35R probably benign Het
Heatr9 A G 11: 83,409,672 (GRCm39) probably benign Het
Krt75 T A 15: 101,476,508 (GRCm39) D419V probably benign Het
Lrig3 A T 10: 125,842,871 (GRCm39) I599F probably benign Het
Lrp4 A G 2: 91,341,925 (GRCm39) D1846G probably damaging Het
Mamdc2 C T 19: 23,281,215 (GRCm39) A653T probably damaging Het
Myo7a A T 7: 97,740,227 (GRCm39) probably null Het
Notch2 A G 3: 98,044,689 (GRCm39) D1537G probably benign Het
Or10k2 G A 8: 84,268,100 (GRCm39) C109Y probably damaging Het
Or51a25 G T 7: 102,372,858 (GRCm39) H280N probably benign Het
Or52ae7 A T 7: 103,119,905 (GRCm39) I220L probably benign Het
Papss1 A C 3: 131,288,280 (GRCm39) D84A probably damaging Het
Pcdhb16 T A 18: 37,611,527 (GRCm39) D162E probably damaging Het
Rab11fip1 C T 8: 27,642,840 (GRCm39) R653Q possibly damaging Het
Rap1gap2 A T 11: 74,303,281 (GRCm39) probably benign Het
Rasal2 T C 1: 156,984,777 (GRCm39) D990G probably damaging Het
Rnf32 T C 5: 29,410,701 (GRCm39) probably null Het
Rp1 T C 1: 4,419,936 (GRCm39) D392G probably benign Het
Scn9a T C 2: 66,398,373 (GRCm39) D79G probably damaging Het
Selenon A T 4: 134,268,219 (GRCm39) V438D probably damaging Het
Slc47a1 G A 11: 61,254,239 (GRCm39) H158Y probably benign Het
Slc5a12 A T 2: 110,471,160 (GRCm39) E463D probably benign Het
Taf2 C T 15: 54,879,959 (GRCm39) V1126M probably benign Het
Tas2r143 G T 6: 42,377,259 (GRCm39) V30L possibly damaging Het
Tcea3 G A 4: 135,995,424 (GRCm39) V256M probably damaging Het
Thy1 A G 9: 43,958,111 (GRCm39) T80A probably benign Het
Tmem9 A G 1: 135,947,469 (GRCm39) N47S probably damaging Het
Tmprss11g T C 5: 86,645,128 (GRCm39) Q101R probably benign Het
Tstd2 A T 4: 46,124,949 (GRCm39) M226K probably damaging Het
Utrn G T 10: 12,613,937 (GRCm39) T378K possibly damaging Het
Vmn2r23 A G 6: 123,681,355 (GRCm39) I88V probably benign Het
Other mutations in Trim66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01539:Trim66 APN 7 109,054,273 (GRCm39) missense probably benign 0.02
IGL01758:Trim66 APN 7 109,085,252 (GRCm39) critical splice donor site probably null
IGL01982:Trim66 APN 7 109,057,970 (GRCm39) missense probably benign 0.00
IGL01983:Trim66 APN 7 109,057,458 (GRCm39) nonsense probably null
IGL02149:Trim66 APN 7 109,060,109 (GRCm39) missense possibly damaging 0.66
IGL02392:Trim66 APN 7 109,059,481 (GRCm39) missense probably benign 0.01
IGL02483:Trim66 APN 7 109,076,837 (GRCm39) splice site probably benign
IGL02945:Trim66 APN 7 109,059,383 (GRCm39) nonsense probably null
IGL03085:Trim66 APN 7 109,057,952 (GRCm39) missense probably benign 0.17
PIT1430001:Trim66 UTSW 7 109,074,454 (GRCm39) missense probably damaging 0.99
R0326:Trim66 UTSW 7 109,059,379 (GRCm39) missense probably benign 0.00
R0358:Trim66 UTSW 7 109,059,383 (GRCm39) nonsense probably null
R0401:Trim66 UTSW 7 109,074,471 (GRCm39) missense probably damaging 0.98
R0470:Trim66 UTSW 7 109,056,749 (GRCm39) splice site probably benign
R0568:Trim66 UTSW 7 109,059,902 (GRCm39) missense probably benign 0.00
R0669:Trim66 UTSW 7 109,054,199 (GRCm39) intron probably benign
R0980:Trim66 UTSW 7 109,054,877 (GRCm39) missense probably damaging 1.00
R1015:Trim66 UTSW 7 109,054,440 (GRCm39) missense probably damaging 1.00
R1078:Trim66 UTSW 7 109,071,526 (GRCm39) missense probably damaging 1.00
R1099:Trim66 UTSW 7 109,074,661 (GRCm39) missense probably benign 0.34
R1181:Trim66 UTSW 7 109,083,784 (GRCm39) critical splice donor site probably null
R1497:Trim66 UTSW 7 109,083,826 (GRCm39) missense probably benign 0.00
R1583:Trim66 UTSW 7 109,054,287 (GRCm39) missense probably damaging 1.00
R1843:Trim66 UTSW 7 109,075,046 (GRCm39) missense probably damaging 0.99
R1998:Trim66 UTSW 7 109,083,784 (GRCm39) critical splice donor site probably null
R2016:Trim66 UTSW 7 109,071,439 (GRCm39) critical splice donor site probably null
R2143:Trim66 UTSW 7 109,074,320 (GRCm39) missense probably damaging 0.98
R2144:Trim66 UTSW 7 109,074,320 (GRCm39) missense probably damaging 0.98
R2145:Trim66 UTSW 7 109,074,320 (GRCm39) missense probably damaging 0.98
R3945:Trim66 UTSW 7 109,071,475 (GRCm39) missense possibly damaging 0.94
R4012:Trim66 UTSW 7 109,057,338 (GRCm39) missense probably damaging 0.98
R4464:Trim66 UTSW 7 109,076,897 (GRCm39) missense possibly damaging 0.51
R4473:Trim66 UTSW 7 109,081,202 (GRCm39) missense probably damaging 1.00
R4729:Trim66 UTSW 7 109,055,267 (GRCm39) critical splice donor site probably null
R4730:Trim66 UTSW 7 109,082,276 (GRCm39) missense probably damaging 1.00
R4775:Trim66 UTSW 7 109,056,796 (GRCm39) nonsense probably null
R4819:Trim66 UTSW 7 109,056,793 (GRCm39) missense probably damaging 1.00
R5269:Trim66 UTSW 7 109,056,797 (GRCm39) missense probably benign 0.00
R5557:Trim66 UTSW 7 109,082,944 (GRCm39) missense probably benign 0.06
R5832:Trim66 UTSW 7 109,054,409 (GRCm39) missense probably damaging 1.00
R6220:Trim66 UTSW 7 109,082,300 (GRCm39) missense probably damaging 0.97
R6243:Trim66 UTSW 7 109,059,481 (GRCm39) missense probably benign 0.01
R6374:Trim66 UTSW 7 109,085,269 (GRCm39) missense probably benign
R6450:Trim66 UTSW 7 109,059,945 (GRCm39) missense probably benign 0.09
R6543:Trim66 UTSW 7 109,075,086 (GRCm39) missense probably benign 0.01
R6788:Trim66 UTSW 7 109,076,961 (GRCm39) missense probably damaging 1.00
R6842:Trim66 UTSW 7 109,059,983 (GRCm39) missense probably benign 0.00
R7169:Trim66 UTSW 7 109,054,328 (GRCm39) missense probably benign 0.25
R7257:Trim66 UTSW 7 109,059,451 (GRCm39) missense probably damaging 1.00
R7328:Trim66 UTSW 7 109,056,958 (GRCm39) missense probably damaging 0.99
R7616:Trim66 UTSW 7 109,082,956 (GRCm39) missense probably damaging 0.99
R8423:Trim66 UTSW 7 109,074,599 (GRCm39) missense possibly damaging 0.77
R8855:Trim66 UTSW 7 109,081,188 (GRCm39) missense probably damaging 1.00
R9130:Trim66 UTSW 7 109,076,896 (GRCm39) missense possibly damaging 0.90
R9137:Trim66 UTSW 7 109,074,330 (GRCm39) missense probably damaging 0.99
R9640:Trim66 UTSW 7 109,074,825 (GRCm39) missense probably damaging 1.00
RF013:Trim66 UTSW 7 109,059,960 (GRCm39) missense probably damaging 0.99
RF024:Trim66 UTSW 7 109,059,947 (GRCm39) missense possibly damaging 0.62
Posted On 2015-12-18