Incidental Mutation 'IGL02833:Olfr794'
ID361519
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr794
Ensembl Gene ENSMUSG00000044293
Gene Nameolfactory receptor 794
SynonymsGA_x6K02T2PULF-11248702-11249664, MOR114-11
Accession Numbers

Genbank: NM_146378

Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL02833
Quality Score
Status
Chromosome10
Chromosomal Location129567655-129573110 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 129570750 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 32 (T32A)
Ref Sequence ENSEMBL: ENSMUSP00000145301 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059957] [ENSMUST00000204820]
Predicted Effect probably benign
Transcript: ENSMUST00000059957
AA Change: T32A

PolyPhen 2 Score 0.256 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000049790
Gene: ENSMUSG00000044293
AA Change: T32A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.8e-49 PFAM
Pfam:7tm_1 39 288 2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204820
AA Change: T32A

PolyPhen 2 Score 0.256 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000145301
Gene: ENSMUSG00000044293
AA Change: T32A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.8e-49 PFAM
Pfam:7tm_1 39 288 2e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833423E24Rik G T 2: 85,502,207 R158S possibly damaging Het
Ache A G 5: 137,291,109 probably benign Het
Atr A T 9: 95,862,852 H74L probably damaging Het
Brca2 A T 5: 150,541,790 H1673L possibly damaging Het
Brwd1 A T 16: 96,052,571 I495K probably damaging Het
Cacna1s A T 1: 136,071,005 I213F probably benign Het
Cds1 T C 5: 101,814,466 S316P possibly damaging Het
Ces1b G A 8: 93,079,410 P68S probably damaging Het
Cilp A G 9: 65,277,924 I434V probably benign Het
Csgalnact2 A G 6: 118,129,268 Y30H probably damaging Het
D430042O09Rik A T 7: 125,850,412 R883* probably null Het
Defb7 T C 8: 19,495,124 V6A probably benign Het
Dlg2 A T 7: 92,431,127 L841F probably damaging Het
Dnajc14 A G 10: 128,806,599 N130S possibly damaging Het
Dock7 T A 4: 98,945,495 D1863V probably damaging Het
Dsp A G 13: 38,192,921 R1561G possibly damaging Het
Gstt4 G T 10: 75,822,340 F28L probably damaging Het
Hectd1 G T 12: 51,764,081 D1690E probably damaging Het
Hspb11 T C 4: 107,275,295 probably benign Het
Hspg2 T C 4: 137,555,130 S3394P probably benign Het
Igf2r A T 17: 12,692,723 C1910S probably damaging Het
Jakmip2 T C 18: 43,575,451 probably benign Het
Kif1b C T 4: 149,246,364 V612M probably damaging Het
Lrrd1 A G 5: 3,850,709 E338G probably damaging Het
Mmp9 C A 2: 164,949,803 D205E probably damaging Het
Mylk A T 16: 34,914,900 H750L probably benign Het
Naip6 A G 13: 100,299,613 S801P probably damaging Het
Nlrp1b A T 11: 71,161,172 M980K probably benign Het
Olfr1173 C A 2: 88,274,432 V206F probably benign Het
Olfr125 G A 17: 37,835,940 V314I probably benign Het
Olfr131 T C 17: 38,082,352 K209E possibly damaging Het
Pdk1 A G 2: 71,897,645 probably null Het
Pex7 A G 10: 19,894,754 S125P probably damaging Het
Pigu T C 2: 155,345,645 probably benign Het
Prr16 T A 18: 51,303,092 H214Q probably damaging Het
Psme4 C T 11: 30,850,715 probably benign Het
Sf3b3 A G 8: 110,811,977 probably null Het
Sp4 T C 12: 118,261,881 I583V probably benign Het
Spata22 A G 11: 73,343,743 T224A probably benign Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Tmem119 T A 5: 113,795,371 Y123F probably damaging Het
Umps A T 16: 33,962,153 L133* probably null Het
Usp46 T A 5: 74,016,682 T179S probably benign Het
Vtcn1 T A 3: 100,888,385 Y223N probably damaging Het
Wiz A G 17: 32,357,879 M567T probably damaging Het
Other mutations in Olfr794
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01867:Olfr794 APN 10 129570827 missense possibly damaging 0.95
IGL02157:Olfr794 APN 10 129571150 missense probably damaging 1.00
IGL02804:Olfr794 APN 10 129571437 missense possibly damaging 0.60
IGL02930:Olfr794 APN 10 129571315 missense probably damaging 1.00
IGL03038:Olfr794 APN 10 129570921 missense probably benign 0.07
G4846:Olfr794 UTSW 10 129571170 missense probably damaging 1.00
R1539:Olfr794 UTSW 10 129570771 missense probably damaging 0.99
R1737:Olfr794 UTSW 10 129570828 missense probably damaging 1.00
R1845:Olfr794 UTSW 10 129571348 missense probably damaging 1.00
R2198:Olfr794 UTSW 10 129571046 nonsense probably null
R3086:Olfr794 UTSW 10 129571407 missense probably damaging 1.00
R4960:Olfr794 UTSW 10 129571026 missense probably damaging 1.00
R5938:Olfr794 UTSW 10 129571527 missense probably damaging 1.00
R6326:Olfr794 UTSW 10 129570702 missense possibly damaging 0.74
R6598:Olfr794 UTSW 10 129571369 missense probably damaging 1.00
R7034:Olfr794 UTSW 10 129571072 missense possibly damaging 0.91
R7066:Olfr794 UTSW 10 129571504 missense probably damaging 1.00
R7226:Olfr794 UTSW 10 129570715 missense probably benign 0.01
R7324:Olfr794 UTSW 10 129570849 missense probably damaging 1.00
R7408:Olfr794 UTSW 10 129570624 start gained probably benign
R7779:Olfr794 UTSW 10 129571311 missense probably damaging 1.00
Z1176:Olfr794 UTSW 10 129571236 nonsense probably null
Posted On2015-12-18