Incidental Mutation 'IGL02833:Pigu'
ID361553
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pigu
Ensembl Gene ENSMUSG00000038383
Gene Namephosphatidylinositol glycan anchor biosynthesis, class U
SynonymsCdc91l1, 5430426F17Rik
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL02833
Quality Score
Status
Chromosome2
Chromosomal Location155278243-155357430 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 155345645 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000126236 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077626] [ENSMUST00000165234]
Predicted Effect probably benign
Transcript: ENSMUST00000077626
SMART Domains Protein: ENSMUSP00000076816
Gene: ENSMUSG00000038383

DomainStartEndE-ValueType
Pfam:PIG-U 10 394 2.6e-119 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124419
Predicted Effect probably benign
Transcript: ENSMUST00000165234
SMART Domains Protein: ENSMUSP00000126236
Gene: ENSMUSG00000038383

DomainStartEndE-ValueType
Pfam:PIG-U 10 393 1.7e-116 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833423E24Rik G T 2: 85,502,207 R158S possibly damaging Het
Ache A G 5: 137,291,109 probably benign Het
Atr A T 9: 95,862,852 H74L probably damaging Het
Brca2 A T 5: 150,541,790 H1673L possibly damaging Het
Brwd1 A T 16: 96,052,571 I495K probably damaging Het
Cacna1s A T 1: 136,071,005 I213F probably benign Het
Cds1 T C 5: 101,814,466 S316P possibly damaging Het
Ces1b G A 8: 93,079,410 P68S probably damaging Het
Cilp A G 9: 65,277,924 I434V probably benign Het
Csgalnact2 A G 6: 118,129,268 Y30H probably damaging Het
D430042O09Rik A T 7: 125,850,412 R883* probably null Het
Defb7 T C 8: 19,495,124 V6A probably benign Het
Dlg2 A T 7: 92,431,127 L841F probably damaging Het
Dnajc14 A G 10: 128,806,599 N130S possibly damaging Het
Dock7 T A 4: 98,945,495 D1863V probably damaging Het
Dsp A G 13: 38,192,921 R1561G possibly damaging Het
Gstt4 G T 10: 75,822,340 F28L probably damaging Het
Hectd1 G T 12: 51,764,081 D1690E probably damaging Het
Hspb11 T C 4: 107,275,295 probably benign Het
Hspg2 T C 4: 137,555,130 S3394P probably benign Het
Igf2r A T 17: 12,692,723 C1910S probably damaging Het
Jakmip2 T C 18: 43,575,451 probably benign Het
Kif1b C T 4: 149,246,364 V612M probably damaging Het
Lrrd1 A G 5: 3,850,709 E338G probably damaging Het
Mmp9 C A 2: 164,949,803 D205E probably damaging Het
Mylk A T 16: 34,914,900 H750L probably benign Het
Naip6 A G 13: 100,299,613 S801P probably damaging Het
Nlrp1b A T 11: 71,161,172 M980K probably benign Het
Olfr1173 C A 2: 88,274,432 V206F probably benign Het
Olfr125 G A 17: 37,835,940 V314I probably benign Het
Olfr131 T C 17: 38,082,352 K209E possibly damaging Het
Olfr794 A G 10: 129,570,750 T32A probably benign Het
Pdk1 A G 2: 71,897,645 probably null Het
Pex7 A G 10: 19,894,754 S125P probably damaging Het
Prr16 T A 18: 51,303,092 H214Q probably damaging Het
Psme4 C T 11: 30,850,715 probably benign Het
Sf3b3 A G 8: 110,811,977 probably null Het
Sp4 T C 12: 118,261,881 I583V probably benign Het
Spata22 A G 11: 73,343,743 T224A probably benign Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Tmem119 T A 5: 113,795,371 Y123F probably damaging Het
Umps A T 16: 33,962,153 L133* probably null Het
Usp46 T A 5: 74,016,682 T179S probably benign Het
Vtcn1 T A 3: 100,888,385 Y223N probably damaging Het
Wiz A G 17: 32,357,879 M567T probably damaging Het
Other mutations in Pigu
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02567:Pigu APN 2 155331192 missense possibly damaging 0.70
IGL03213:Pigu APN 2 155335371 missense probably damaging 1.00
R1645:Pigu UTSW 2 155328678 nonsense probably null
R2426:Pigu UTSW 2 155299082 missense probably damaging 1.00
R3816:Pigu UTSW 2 155299143 missense probably damaging 1.00
R3879:Pigu UTSW 2 155299143 missense probably damaging 1.00
R5017:Pigu UTSW 2 155299208 intron probably null
R5215:Pigu UTSW 2 155335329 intron probably benign
R5557:Pigu UTSW 2 155278629 nonsense probably null
R6106:Pigu UTSW 2 155297196 missense possibly damaging 0.67
R6718:Pigu UTSW 2 155301286 missense possibly damaging 0.49
R7140:Pigu UTSW 2 155301240 missense possibly damaging 0.78
R7358:Pigu UTSW 2 155299170 missense probably damaging 1.00
R7467:Pigu UTSW 2 155299089 missense probably damaging 1.00
R7503:Pigu UTSW 2 155331144 splice site probably null
R7844:Pigu UTSW 2 155292720 nonsense probably null
R7927:Pigu UTSW 2 155292720 nonsense probably null
Z1177:Pigu UTSW 2 155299148 missense probably damaging 1.00
Posted On2015-12-18