Incidental Mutation 'IGL02834:Olfr631'
ID361567
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr631
Ensembl Gene ENSMUSG00000042219
Gene Nameolfactory receptor 631
SynonymsMOR3-1, GA_x6K02T2PBJ9-6662699-6663658
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.116) question?
Stock #IGL02834
Quality Score
Status
Chromosome7
Chromosomal Location103928825-103929784 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 103929394 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 190 (C190*)
Ref Sequence ENSEMBL: ENSMUSP00000102476 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106863] [ENSMUST00000214711]
Predicted Effect probably null
Transcript: ENSMUST00000106863
AA Change: C190*
SMART Domains Protein: ENSMUSP00000102476
Gene: ENSMUSG00000042219
AA Change: C190*

DomainStartEndE-ValueType
Pfam:7tm_4 32 311 2e-114 PFAM
Pfam:7TM_GPCR_Srsx 36 308 6.6e-8 PFAM
Pfam:7tm_1 42 293 4.8e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214509
Predicted Effect probably benign
Transcript: ENSMUST00000214711
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530099J19Rik A T 13: 19,729,875 noncoding transcript Het
Arhgap10 A T 8: 77,365,100 L430Q probably damaging Het
Cc2d2a C T 5: 43,714,521 R900* probably null Het
Cd14 A G 18: 36,725,503 Y300H probably benign Het
Dgcr8 T A 16: 18,272,759 T584S probably benign Het
Epb41l5 C T 1: 119,623,955 G100D probably benign Het
Fat4 G A 3: 38,956,744 G1998R probably damaging Het
Fndc3b A T 3: 27,508,503 L279H probably damaging Het
Gabrr1 A G 4: 33,151,426 E114G probably damaging Het
Hrh2 A G 13: 54,215,000 R332G probably benign Het
Kif5a T C 10: 127,245,756 I180V probably benign Het
Lyg2 T A 1: 37,909,967 R105W probably damaging Het
Myc A G 15: 61,987,666 I64V probably damaging Het
Nrcam G A 12: 44,541,075 probably null Het
Ogdhl A G 14: 32,325,946 Y51C probably damaging Het
Olfr1339 C T 4: 118,734,606 L26F probably benign Het
Pdlim3 A G 8: 45,917,532 R290G probably benign Het
Ppm1l G A 3: 69,549,343 A198T probably damaging Het
Prkd2 A G 7: 16,845,934 D119G probably damaging Het
Rapgef3 A T 15: 97,748,265 I820N probably damaging Het
Scnn1b A G 7: 121,912,062 Y324C probably damaging Het
Smc5 G A 19: 23,257,604 R289C probably benign Het
Vmn2r51 T A 7: 10,098,136 R508* probably null Het
Vps13c A T 9: 67,937,855 I2074L probably benign Het
Wdr64 T C 1: 175,805,849 probably benign Het
Ydjc C T 16: 17,147,289 P74L probably benign Het
Other mutations in Olfr631
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02632:Olfr631 APN 7 103929707 missense possibly damaging 0.93
IGL02732:Olfr631 APN 7 103929129 missense probably damaging 1.00
IGL03089:Olfr631 APN 7 103929122 missense probably benign 0.01
IGL03137:Olfr631 APN 7 103929594 missense probably benign
IGL03407:Olfr631 APN 7 103928951 missense probably damaging 1.00
R0034:Olfr631 UTSW 7 103929501 missense probably benign 0.04
R1768:Olfr631 UTSW 7 103929725 nonsense probably null
R1779:Olfr631 UTSW 7 103929461 missense probably benign 0.39
R1933:Olfr631 UTSW 7 103929130 missense probably damaging 0.99
R4976:Olfr631 UTSW 7 103929737 missense probably benign
R5783:Olfr631 UTSW 7 103928942 missense probably damaging 1.00
R5888:Olfr631 UTSW 7 103929032 missense possibly damaging 0.47
R6051:Olfr631 UTSW 7 103928877 missense probably damaging 0.98
R7016:Olfr631 UTSW 7 103929530 missense probably benign 0.01
Posted On2015-12-18