Incidental Mutation 'IGL02834:Lyg2'
ID361579
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lyg2
Ensembl Gene ENSMUSG00000061584
Gene Namelysozyme G-like 2
SynonymsLOC332427
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL02834
Quality Score
Status
Chromosome1
Chromosomal Location37905923-37916493 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 37909967 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Tryptophan at position 105 (R105W)
Ref Sequence ENSEMBL: ENSMUSP00000077422 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078307]
Predicted Effect probably damaging
Transcript: ENSMUST00000078307
AA Change: R105W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077422
Gene: ENSMUSG00000061584
AA Change: R105W

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
SCOP:d153l__ 39 213 5e-45 SMART
PDB:1LSP|A 40 213 2e-56 PDB
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SLT domain, a protein domain present in bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyglucosamine (GlcNAc). [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530099J19Rik A T 13: 19,729,875 noncoding transcript Het
Arhgap10 A T 8: 77,365,100 L430Q probably damaging Het
Cc2d2a C T 5: 43,714,521 R900* probably null Het
Cd14 A G 18: 36,725,503 Y300H probably benign Het
Dgcr8 T A 16: 18,272,759 T584S probably benign Het
Epb41l5 C T 1: 119,623,955 G100D probably benign Het
Fat4 G A 3: 38,956,744 G1998R probably damaging Het
Fndc3b A T 3: 27,508,503 L279H probably damaging Het
Gabrr1 A G 4: 33,151,426 E114G probably damaging Het
Hrh2 A G 13: 54,215,000 R332G probably benign Het
Kif5a T C 10: 127,245,756 I180V probably benign Het
Myc A G 15: 61,987,666 I64V probably damaging Het
Nrcam G A 12: 44,541,075 probably null Het
Ogdhl A G 14: 32,325,946 Y51C probably damaging Het
Olfr1339 C T 4: 118,734,606 L26F probably benign Het
Olfr631 T A 7: 103,929,394 C190* probably null Het
Pdlim3 A G 8: 45,917,532 R290G probably benign Het
Ppm1l G A 3: 69,549,343 A198T probably damaging Het
Prkd2 A G 7: 16,845,934 D119G probably damaging Het
Rapgef3 A T 15: 97,748,265 I820N probably damaging Het
Scnn1b A G 7: 121,912,062 Y324C probably damaging Het
Smc5 G A 19: 23,257,604 R289C probably benign Het
Vmn2r51 T A 7: 10,098,136 R508* probably null Het
Vps13c A T 9: 67,937,855 I2074L probably benign Het
Wdr64 T C 1: 175,805,849 probably benign Het
Ydjc C T 16: 17,147,289 P74L probably benign Het
Other mutations in Lyg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03079:Lyg2 APN 1 37907646 missense possibly damaging 0.90
IGL03123:Lyg2 APN 1 37915764 utr 5 prime probably benign
R0543:Lyg2 UTSW 1 37911107 missense possibly damaging 0.94
R2250:Lyg2 UTSW 1 37915735 missense probably benign 0.25
R2258:Lyg2 UTSW 1 37908996 missense probably benign 0.00
R3884:Lyg2 UTSW 1 37910069 missense probably damaging 1.00
R4807:Lyg2 UTSW 1 37911067 missense possibly damaging 0.54
R5991:Lyg2 UTSW 1 37915719 critical splice donor site probably null
R6328:Lyg2 UTSW 1 37911113 missense probably benign 0.33
R7439:Lyg2 UTSW 1 37911137 missense possibly damaging 0.46
Posted On2015-12-18