Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02836:Or9m1'

361671

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or9m1

Ensembl Gene

ENSMUSG00000075146

Gene Name

olfactory receptor family 9 subfamily M member 1

Synonyms

Olfr1154, MOR173-2, GA_x6K02T2Q125-49403456-49402524

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

IGL02836

Quality Score

Status

Chromosome

Chromosomal Location

87733086-87734018 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 87733724 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 99 (T99P)

Ref Sequence

ENSEMBL: ENSMUSP00000148909 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099844] [ENSMUST00000215017] [ENSMUST00000215862]

AlphaFold

L7MU57

Predicted Effect

possibly damaging
Transcript: ENSMUST00000099844
AA Change: T99P

PolyPhen 2 Score 0.806 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000097432
Gene: ENSMUSG00000075146
AA Change: T99P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	8.1e-47	PFAM
Pfam:7tm_1	41	289	3.6e-18	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215017
AA Change: T99P

PolyPhen 2 Score 0.806 (Sensitivity: 0.84; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215862
AA Change: T99P

PolyPhen 2 Score 0.806 (Sensitivity: 0.84; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4	T	A	4: 144,349,782 (GRCm39)	N346K	possibly damaging	Het
Abca15	A	G	7: 119,987,439 (GRCm39)	M1242V	probably benign	Het
Abca6	T	A	11: 110,139,374 (GRCm39)	E33D	probably damaging	Het
Abca8a	T	C	11: 109,961,177 (GRCm39)	K582E	possibly damaging	Het
Abcb6	A	G	1: 75,154,646 (GRCm39)	L263P	probably damaging	Het
Adamts2	A	C	11: 50,678,106 (GRCm39)	E795A	probably damaging	Het
Avil	T	A	10: 126,844,864 (GRCm39)	I292N	probably damaging	Het
Cd300ld2	T	C	11: 114,904,576 (GRCm39)	D97G	probably benign	Het
Cfh	A	C	1: 140,030,137 (GRCm39)	I912R	probably damaging	Het
Cyp26c1	A	T	19: 37,675,604 (GRCm39)	Q156L	probably benign	Het
Dhx57	T	C	17: 80,574,978 (GRCm39)	I614V	probably damaging	Het
Dip2c	T	A	13: 9,660,826 (GRCm39)	S896T	probably damaging	Het
Dmtn	G	T	14: 70,853,518 (GRCm39)	P97Q	probably damaging	Het
Dock6	A	T	9: 21,713,160 (GRCm39)	V1931E	probably damaging	Het
Dpep2	C	A	8: 106,717,227 (GRCm39)		probably null	Het
Dsg1c	T	A	18: 20,400,986 (GRCm39)	L163Q	probably benign	Het
Esyt3	A	G	9: 99,202,960 (GRCm39)		probably benign	Het
Fcgbp	T	A	7: 27,816,783 (GRCm39)	I2415N	possibly damaging	Het
Fpr-rs6	T	C	17: 20,403,307 (GRCm39)	D18G	probably benign	Het
Fras1	T	C	5: 96,682,725 (GRCm39)	V74A	possibly damaging	Het
Frem3	T	C	8: 81,341,010 (GRCm39)	V1101A	probably benign	Het
Fut8	T	A	12: 77,496,987 (GRCm39)	V399E	probably benign	Het
Galntl5	G	T	5: 25,391,237 (GRCm39)	K45N	probably benign	Het
Gbe1	A	G	16: 70,357,983 (GRCm39)	Y669C	possibly damaging	Het
Gcnt1	T	C	19: 17,307,493 (GRCm39)	I77M	probably benign	Het
Itprid1	T	A	6: 55,875,075 (GRCm39)	W342R	probably damaging	Het
Mark2	A	G	19: 7,255,405 (GRCm39)		probably null	Het
Muc2	A	T	7: 141,300,450 (GRCm39)		probably benign	Het
Nacc2	C	T	2: 25,980,329 (GRCm39)	V36I	probably damaging	Het
Nphp1	T	C	2: 127,611,543 (GRCm39)	I268V	probably benign	Het
Oosp3	A	G	19: 11,678,332 (GRCm39)	I5V	probably benign	Het
Pex7	A	G	10: 19,769,990 (GRCm39)		probably benign	Het
Prr14l	T	C	5: 32,988,440 (GRCm39)	K352E	probably benign	Het
Rheb	T	A	5: 25,008,709 (GRCm39)	I170F	probably benign	Het
Rpgrip1	A	G	14: 52,382,714 (GRCm39)		probably null	Het
Rps2	T	A	17: 24,939,650 (GRCm39)	L107Q	probably damaging	Het
Rrp1	A	T	10: 78,240,874 (GRCm39)		probably benign	Het
Rtcb	A	T	10: 85,779,806 (GRCm39)	V288D	possibly damaging	Het
Sec14l3	T	C	11: 4,020,084 (GRCm39)	F174L	probably benign	Het
Slc28a1	G	A	7: 80,775,909 (GRCm39)	V202M	probably damaging	Het
Slc44a3	A	T	3: 121,325,366 (GRCm39)	C32S	probably damaging	Het
Syne1	G	A	10: 5,359,875 (GRCm39)		probably benign	Het
Synrg	C	A	11: 83,892,804 (GRCm39)		probably benign	Het
Tmem219	A	T	7: 126,488,121 (GRCm39)	F265I	probably benign	Het
Tmem94	T	C	11: 115,683,765 (GRCm39)	I726T	probably damaging	Het
Trim37	T	C	11: 87,087,785 (GRCm39)	M632T	probably benign	Het
Trpm6	A	T	19: 18,790,846 (GRCm39)	Q627L	probably damaging	Het
Uvrag	A	G	7: 98,628,984 (GRCm39)	V361A	possibly damaging	Het
Yipf3	C	A	17: 46,562,520 (GRCm39)	N308K	possibly damaging	Het
Zfp438	A	G	18: 5,245,427 (GRCm39)		probably benign	Het
Zmiz1	T	A	14: 25,657,166 (GRCm39)		probably benign	Het
Zranb3	A	G	1: 127,888,562 (GRCm39)	V841A	probably benign	Het

Other mutations in Or9m1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01360:Or9m1	APN	2	87,733,871 (GRCm39)	missense	probably benign	0.00
IGL01878:Or9m1	APN	2	87,733,675 (GRCm39)	nonsense	probably null
IGL02683:Or9m1	APN	2	87,733,448 (GRCm39)	missense	possibly damaging	0.80
R0432:Or9m1	UTSW	2	87,733,304 (GRCm39)	missense	probably damaging	1.00
R1123:Or9m1	UTSW	2	87,733,248 (GRCm39)	missense	probably damaging	0.99
R1223:Or9m1	UTSW	2	87,733,163 (GRCm39)	missense	probably damaging	0.99
R1561:Or9m1	UTSW	2	87,733,505 (GRCm39)	missense	probably benign	0.00
R1964:Or9m1	UTSW	2	87,734,011 (GRCm39)	missense	probably benign	0.00
R2041:Or9m1	UTSW	2	87,733,141 (GRCm39)	missense	probably damaging	1.00
R2219:Or9m1	UTSW	2	87,733,269 (GRCm39)	nonsense	probably null
R2233:Or9m1	UTSW	2	87,733,819 (GRCm39)	missense	probably damaging	1.00
R3719:Or9m1	UTSW	2	87,733,447 (GRCm39)	missense	probably benign	0.05
R4826:Or9m1	UTSW	2	87,733,693 (GRCm39)	missense	probably damaging	1.00
R4908:Or9m1	UTSW	2	87,733,533 (GRCm39)	missense	probably damaging	1.00
R5056:Or9m1	UTSW	2	87,733,915 (GRCm39)	missense	probably damaging	1.00
R5589:Or9m1	UTSW	2	87,733,691 (GRCm39)	missense	probably benign	0.26
R6477:Or9m1	UTSW	2	87,733,334 (GRCm39)	missense	probably damaging	1.00
R6532:Or9m1	UTSW	2	87,733,546 (GRCm39)	missense	probably damaging	1.00
R6666:Or9m1	UTSW	2	87,733,852 (GRCm39)	missense	probably damaging	1.00
R6693:Or9m1	UTSW	2	87,733,652 (GRCm39)	missense	probably damaging	1.00
R6724:Or9m1	UTSW	2	87,733,946 (GRCm39)	missense	probably benign	0.00
R7784:Or9m1	UTSW	2	87,733,537 (GRCm39)	missense	probably benign	0.01
R8099:Or9m1	UTSW	2	87,733,852 (GRCm39)	missense	probably damaging	1.00
R8168:Or9m1	UTSW	2	87,733,543 (GRCm39)	missense	probably damaging	0.97
R8917:Or9m1	UTSW	2	87,733,307 (GRCm39)	missense	possibly damaging	0.81
R8998:Or9m1	UTSW	2	87,733,189 (GRCm39)	missense	probably damaging	1.00
R9039:Or9m1	UTSW	2	87,733,907 (GRCm39)	missense	probably damaging	0.98
R9093:Or9m1	UTSW	2	87,733,480 (GRCm39)	missense	probably benign	0.44
R9139:Or9m1	UTSW	2	87,733,108 (GRCm39)	missense	probably benign	0.04
R9780:Or9m1	UTSW	2	87,733,426 (GRCm39)	missense	probably damaging	1.00
Z1088:Or9m1	UTSW	2	87,733,928 (GRCm39)	missense	possibly damaging	0.87

Posted On

2015-12-18