Incidental Mutation 'IGL02836:Dpep2'
ID361677
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpep2
Ensembl Gene ENSMUSG00000115067
Gene Namedipeptidase 2
SynonymsF630103D06Rik, MBD-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.208) question?
Stock #IGL02836
Quality Score
Status
Chromosome8
Chromosomal Location105984945-105996423 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to A at 105990595 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000154250 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034373] [ENSMUST00000117555] [ENSMUST00000142898] [ENSMUST00000227363] [ENSMUST00000227778]
Predicted Effect probably null
Transcript: ENSMUST00000034373
SMART Domains Protein: ENSMUSP00000034373
Gene: ENSMUSG00000053687

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
Pfam:Peptidase_M19 80 401 3.4e-112 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000081998
SMART Domains Protein: ENSMUSP00000080659
Gene: ENSMUSG00000115067

DomainStartEndE-ValueType
low complexity region 97 113 N/A INTRINSIC
Pfam:Peptidase_M19 166 501 1.2e-104 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083297
Predicted Effect probably benign
Transcript: ENSMUST00000117555
SMART Domains Protein: ENSMUSP00000113877
Gene: ENSMUSG00000053687

DomainStartEndE-ValueType
Pfam:Peptidase_M19 1 308 5.7e-107 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142898
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149057
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150001
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212917
Predicted Effect probably null
Transcript: ENSMUST00000227363
Predicted Effect probably benign
Transcript: ENSMUST00000227778
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 T A 4: 144,623,212 N346K possibly damaging Het
Abca15 A G 7: 120,388,216 M1242V probably benign Het
Abca6 T A 11: 110,248,548 E33D probably damaging Het
Abca8a T C 11: 110,070,351 K582E possibly damaging Het
Abcb6 A G 1: 75,178,002 L263P probably damaging Het
Adamts2 A C 11: 50,787,279 E795A probably damaging Het
Avil T A 10: 127,008,995 I292N probably damaging Het
Ccdc129 T A 6: 55,898,090 W342R probably damaging Het
Cd300ld2 T C 11: 115,013,750 D97G probably benign Het
Cfh A C 1: 140,102,399 I912R probably damaging Het
Cyp26c1 A T 19: 37,687,156 Q156L probably benign Het
Dhx57 T C 17: 80,267,549 I614V probably damaging Het
Dip2c T A 13: 9,610,790 S896T probably damaging Het
Dmtn G T 14: 70,616,078 P97Q probably damaging Het
Dock6 A T 9: 21,801,864 V1931E probably damaging Het
Dsg1c T A 18: 20,267,929 L163Q probably benign Het
Esyt3 A G 9: 99,320,907 probably benign Het
Fcgbp T A 7: 28,117,358 I2415N possibly damaging Het
Fpr-rs6 T C 17: 20,183,045 D18G probably benign Het
Fras1 T C 5: 96,534,866 V74A possibly damaging Het
Frem3 T C 8: 80,614,381 V1101A probably benign Het
Fut8 T A 12: 77,450,213 V399E probably benign Het
Galntl5 G T 5: 25,186,239 K45N probably benign Het
Gbe1 A G 16: 70,561,095 Y669C possibly damaging Het
Gcnt1 T C 19: 17,330,129 I77M probably benign Het
Mark2 A G 19: 7,278,040 probably null Het
Muc2 A T 7: 141,746,713 probably benign Het
Nacc2 C T 2: 26,090,317 V36I probably damaging Het
Nphp1 T C 2: 127,769,623 I268V probably benign Het
Olfr1154 T G 2: 87,903,380 T99P possibly damaging Het
Oosp3 A G 19: 11,700,968 I5V probably benign Het
Pex7 A G 10: 19,894,244 probably benign Het
Prr14l T C 5: 32,831,096 K352E probably benign Het
Rheb T A 5: 24,803,711 I170F probably benign Het
Rpgrip1 A G 14: 52,145,257 probably null Het
Rps2 T A 17: 24,720,676 L107Q probably damaging Het
Rrp1 A T 10: 78,405,040 probably benign Het
Rtcb A T 10: 85,943,942 V288D possibly damaging Het
Sec14l3 T C 11: 4,070,084 F174L probably benign Het
Slc28a1 G A 7: 81,126,161 V202M probably damaging Het
Slc44a3 A T 3: 121,531,717 C32S probably damaging Het
Syne1 G A 10: 5,409,875 probably benign Het
Synrg C A 11: 84,001,978 probably benign Het
Tmem219 A T 7: 126,888,949 F265I probably benign Het
Tmem94 T C 11: 115,792,939 I726T probably damaging Het
Trim37 T C 11: 87,196,959 M632T probably benign Het
Trpm6 A T 19: 18,813,482 Q627L probably damaging Het
Uvrag A G 7: 98,979,777 V361A possibly damaging Het
Yipf3 C A 17: 46,251,594 N308K possibly damaging Het
Zfp438 A G 18: 5,245,427 probably benign Het
Zmiz1 T A 14: 25,656,742 probably benign Het
Zranb3 A G 1: 127,960,825 V841A probably benign Het
Other mutations in Dpep2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00590:Dpep2 APN 8 105988821 missense probably damaging 1.00
IGL01160:Dpep2 APN 8 105986444 missense possibly damaging 0.95
IGL02071:Dpep2 APN 8 105985144 missense probably benign 0.01
IGL02441:Dpep2 APN 8 105985091 missense probably benign 0.00
IGL02517:Dpep2 APN 8 105988756 missense probably damaging 1.00
R0504:Dpep2 UTSW 8 105989988 missense probably benign 0.29
R1866:Dpep2 UTSW 8 105989448 critical splice donor site probably null
R1982:Dpep2 UTSW 8 105989455 nonsense probably null
R2172:Dpep2 UTSW 8 105988998 missense possibly damaging 0.88
R2399:Dpep2 UTSW 8 105989592 missense probably damaging 1.00
R4369:Dpep2 UTSW 8 105985075 missense probably benign 0.00
R4499:Dpep2 UTSW 8 105985482 missense probably benign 0.32
R4500:Dpep2 UTSW 8 105985482 missense probably benign 0.32
R4774:Dpep2 UTSW 8 105990756 missense possibly damaging 0.48
R5114:Dpep2 UTSW 8 105986193 missense probably damaging 1.00
R5727:Dpep2 UTSW 8 105986443 missense probably benign 0.00
R6052:Dpep2 UTSW 8 105990638 missense possibly damaging 0.91
R6177:Dpep2 UTSW 8 105986199 missense probably damaging 1.00
R6658:Dpep2 UTSW 8 105989910 missense probably benign 0.01
R6822:Dpep2 UTSW 8 105985241 missense probably benign 0.01
R7854:Dpep2 UTSW 8 105989528 missense
R7866:Dpep2 UTSW 8 105989481 missense
R7937:Dpep2 UTSW 8 105989528 missense
R7949:Dpep2 UTSW 8 105989481 missense
R8169:Dpep2 UTSW 8 105996217 missense
V7732:Dpep2 UTSW 8 105989260 missense probably damaging 1.00
Posted On2015-12-18