Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02836:Zfp438'

361681

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp438

Ensembl Gene

ENSMUSG00000050945

Gene Name

zinc finger protein 438

Synonyms

9430091M14Rik, B830013J05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

IGL02836

Quality Score

Status

Chromosome

Chromosomal Location

5210029-5334807 bp(-) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

A to G at 5245427 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000067049 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063989]

AlphaFold

Q8BFX2

Predicted Effect

probably benign
Transcript: ENSMUST00000063989

SMART Domains

Protein: ENSMUSP00000067049
Gene: ENSMUSG00000050945

Domain	Start	End	E-Value	Type
low complexity region	132	151	N/A	INTRINSIC
low complexity region	263	274	N/A	INTRINSIC
low complexity region	427	439	N/A	INTRINSIC
ZnF_C2H2	493	515	5.72e-1	SMART
ZnF_C2H2	521	543	7.26e-3	SMART
ZnF_C2H2	553	576	5.2e0	SMART
ZnF_C2H2	635	658	1.86e1	SMART
ZnF_C2H2	746	769	1.13e1	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4	T	A	4: 144,349,782 (GRCm39)	N346K	possibly damaging	Het
Abca15	A	G	7: 119,987,439 (GRCm39)	M1242V	probably benign	Het
Abca6	T	A	11: 110,139,374 (GRCm39)	E33D	probably damaging	Het
Abca8a	T	C	11: 109,961,177 (GRCm39)	K582E	possibly damaging	Het
Abcb6	A	G	1: 75,154,646 (GRCm39)	L263P	probably damaging	Het
Adamts2	A	C	11: 50,678,106 (GRCm39)	E795A	probably damaging	Het
Avil	T	A	10: 126,844,864 (GRCm39)	I292N	probably damaging	Het
Cd300ld2	T	C	11: 114,904,576 (GRCm39)	D97G	probably benign	Het
Cfh	A	C	1: 140,030,137 (GRCm39)	I912R	probably damaging	Het
Cyp26c1	A	T	19: 37,675,604 (GRCm39)	Q156L	probably benign	Het
Dhx57	T	C	17: 80,574,978 (GRCm39)	I614V	probably damaging	Het
Dip2c	T	A	13: 9,660,826 (GRCm39)	S896T	probably damaging	Het
Dmtn	G	T	14: 70,853,518 (GRCm39)	P97Q	probably damaging	Het
Dock6	A	T	9: 21,713,160 (GRCm39)	V1931E	probably damaging	Het
Dpep2	C	A	8: 106,717,227 (GRCm39)		probably null	Het
Dsg1c	T	A	18: 20,400,986 (GRCm39)	L163Q	probably benign	Het
Esyt3	A	G	9: 99,202,960 (GRCm39)		probably benign	Het
Fcgbp	T	A	7: 27,816,783 (GRCm39)	I2415N	possibly damaging	Het
Fpr-rs6	T	C	17: 20,403,307 (GRCm39)	D18G	probably benign	Het
Fras1	T	C	5: 96,682,725 (GRCm39)	V74A	possibly damaging	Het
Frem3	T	C	8: 81,341,010 (GRCm39)	V1101A	probably benign	Het
Fut8	T	A	12: 77,496,987 (GRCm39)	V399E	probably benign	Het
Galntl5	G	T	5: 25,391,237 (GRCm39)	K45N	probably benign	Het
Gbe1	A	G	16: 70,357,983 (GRCm39)	Y669C	possibly damaging	Het
Gcnt1	T	C	19: 17,307,493 (GRCm39)	I77M	probably benign	Het
Itprid1	T	A	6: 55,875,075 (GRCm39)	W342R	probably damaging	Het
Mark2	A	G	19: 7,255,405 (GRCm39)		probably null	Het
Muc2	A	T	7: 141,300,450 (GRCm39)		probably benign	Het
Nacc2	C	T	2: 25,980,329 (GRCm39)	V36I	probably damaging	Het
Nphp1	T	C	2: 127,611,543 (GRCm39)	I268V	probably benign	Het
Oosp3	A	G	19: 11,678,332 (GRCm39)	I5V	probably benign	Het
Or9m1	T	G	2: 87,733,724 (GRCm39)	T99P	possibly damaging	Het
Pex7	A	G	10: 19,769,990 (GRCm39)		probably benign	Het
Prr14l	T	C	5: 32,988,440 (GRCm39)	K352E	probably benign	Het
Rheb	T	A	5: 25,008,709 (GRCm39)	I170F	probably benign	Het
Rpgrip1	A	G	14: 52,382,714 (GRCm39)		probably null	Het
Rps2	T	A	17: 24,939,650 (GRCm39)	L107Q	probably damaging	Het
Rrp1	A	T	10: 78,240,874 (GRCm39)		probably benign	Het
Rtcb	A	T	10: 85,779,806 (GRCm39)	V288D	possibly damaging	Het
Sec14l3	T	C	11: 4,020,084 (GRCm39)	F174L	probably benign	Het
Slc28a1	G	A	7: 80,775,909 (GRCm39)	V202M	probably damaging	Het
Slc44a3	A	T	3: 121,325,366 (GRCm39)	C32S	probably damaging	Het
Syne1	G	A	10: 5,359,875 (GRCm39)		probably benign	Het
Synrg	C	A	11: 83,892,804 (GRCm39)		probably benign	Het
Tmem219	A	T	7: 126,488,121 (GRCm39)	F265I	probably benign	Het
Tmem94	T	C	11: 115,683,765 (GRCm39)	I726T	probably damaging	Het
Trim37	T	C	11: 87,087,785 (GRCm39)	M632T	probably benign	Het
Trpm6	A	T	19: 18,790,846 (GRCm39)	Q627L	probably damaging	Het
Uvrag	A	G	7: 98,628,984 (GRCm39)	V361A	possibly damaging	Het
Yipf3	C	A	17: 46,562,520 (GRCm39)	N308K	possibly damaging	Het
Zmiz1	T	A	14: 25,657,166 (GRCm39)		probably benign	Het
Zranb3	A	G	1: 127,888,562 (GRCm39)	V841A	probably benign	Het

Other mutations in Zfp438

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01907:Zfp438	APN	18	5,213,815 (GRCm39)	missense	probably damaging	1.00
IGL01967:Zfp438	APN	18	5,214,049 (GRCm39)	missense	probably benign	0.00
IGL02003:Zfp438	APN	18	5,214,503 (GRCm39)	missense	probably benign	0.15
IGL02305:Zfp438	APN	18	5,213,674 (GRCm39)	missense	possibly damaging	0.84
IGL02439:Zfp438	APN	18	5,213,216 (GRCm39)	missense	probably damaging	1.00
IGL02744:Zfp438	APN	18	5,214,760 (GRCm39)	missense	probably benign	0.03
R0308:Zfp438	UTSW	18	5,213,638 (GRCm39)	missense	probably benign	0.00
R0437:Zfp438	UTSW	18	5,214,910 (GRCm39)	missense	probably damaging	0.97
R1540:Zfp438	UTSW	18	5,210,740 (GRCm39)	missense	probably benign	0.04
R1594:Zfp438	UTSW	18	5,213,515 (GRCm39)	missense	possibly damaging	0.94
R1804:Zfp438	UTSW	18	5,213,689 (GRCm39)	missense	probably damaging	1.00
R2057:Zfp438	UTSW	18	5,214,085 (GRCm39)	missense	probably benign	0.03
R2256:Zfp438	UTSW	18	5,213,508 (GRCm39)	missense	probably damaging	0.99
R4549:Zfp438	UTSW	18	5,214,073 (GRCm39)	missense	probably benign	0.01
R4747:Zfp438	UTSW	18	5,214,403 (GRCm39)	missense	probably benign	0.00
R4858:Zfp438	UTSW	18	5,213,154 (GRCm39)	missense	probably benign	0.01
R4887:Zfp438	UTSW	18	5,213,776 (GRCm39)	missense	possibly damaging	0.55
R5543:Zfp438	UTSW	18	5,213,761 (GRCm39)	missense	probably damaging	1.00
R5646:Zfp438	UTSW	18	5,214,526 (GRCm39)	missense	probably benign	0.36
R6022:Zfp438	UTSW	18	5,213,419 (GRCm39)	missense	probably damaging	1.00
R6058:Zfp438	UTSW	18	5,213,209 (GRCm39)	missense	probably damaging	1.00
R6460:Zfp438	UTSW	18	5,213,603 (GRCm39)	missense	probably damaging	1.00
R6703:Zfp438	UTSW	18	5,214,044 (GRCm39)	missense	probably benign	0.05
R6766:Zfp438	UTSW	18	5,213,780 (GRCm39)	missense	probably benign	0.07
R7252:Zfp438	UTSW	18	5,214,874 (GRCm39)	nonsense	probably null
R7283:Zfp438	UTSW	18	5,214,712 (GRCm39)	missense	probably damaging	1.00
R7429:Zfp438	UTSW	18	5,214,139 (GRCm39)	missense	probably benign	0.01
R7769:Zfp438	UTSW	18	5,213,377 (GRCm39)	missense	possibly damaging	0.93
R8139:Zfp438	UTSW	18	5,214,013 (GRCm39)	missense	probably benign	0.01
R8291:Zfp438	UTSW	18	5,211,010 (GRCm39)	nonsense	probably null
R8802:Zfp438	UTSW	18	5,213,417 (GRCm39)	missense	possibly damaging	0.88
R8819:Zfp438	UTSW	18	5,213,383 (GRCm39)	missense	possibly damaging	0.91
R8922:Zfp438	UTSW	18	5,213,422 (GRCm39)	missense	possibly damaging	0.65
R9224:Zfp438	UTSW	18	5,210,788 (GRCm39)	missense	probably damaging	1.00
R9416:Zfp438	UTSW	18	5,214,054 (GRCm39)	missense	probably benign	0.01
R9442:Zfp438	UTSW	18	5,214,379 (GRCm39)	missense	probably benign	0.00
R9529:Zfp438	UTSW	18	5,213,501 (GRCm39)	missense	possibly damaging	0.61

Posted On

2015-12-18