Incidental Mutation 'IGL02838:Olfr735'
ID361729
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr735
Ensembl Gene ENSMUSG00000046210
Gene Nameolfactory receptor 735
SynonymsMOR243-1, GA_x6K02T2PMLR-6042130-6041183
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #IGL02838
Quality Score
Status
Chromosome14
Chromosomal Location50342612-50348872 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 50345855 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 165 (S165P)
Ref Sequence ENSEMBL: ENSMUSP00000153148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049729] [ENSMUST00000216634]
Predicted Effect probably damaging
Transcript: ENSMUST00000049729
AA Change: S196P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000056851
Gene: ENSMUSG00000046210
AA Change: S196P

DomainStartEndE-ValueType
transmembrane domain 9 28 N/A INTRINSIC
Pfam:7tm_4 70 345 1.6e-49 PFAM
Pfam:7tm_1 80 345 1.8e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206145
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206546
Predicted Effect probably damaging
Transcript: ENSMUST00000216634
AA Change: S165P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl4a T C 12: 40,036,304 E148G probably benign Het
AW551984 A T 9: 39,594,643 F419L probably damaging Het
Brpf3 G A 17: 28,835,784 R1100Q probably benign Het
Cacna1e A G 1: 154,445,648 C1222R probably damaging Het
Cacna2d3 T A 14: 29,300,828 probably null Het
Ccdc146 T A 5: 21,297,569 M775L probably benign Het
Ccdc60 A G 5: 116,134,110 S422P probably damaging Het
Cdh10 A T 15: 18,899,763 N59Y probably damaging Het
Cfap61 T A 2: 145,947,164 C29* probably null Het
Fgd5 T A 6: 91,987,674 M138K probably benign Het
Gpr107 G A 2: 31,214,317 G545S probably benign Het
Greb1l G A 18: 10,560,430 A1897T probably damaging Het
Hcls1 A G 16: 36,962,419 D439G probably damaging Het
Iars T A 13: 49,690,489 N146K possibly damaging Het
Itga5 C T 15: 103,351,609 A619T probably damaging Het
Maml3 A G 3: 51,690,090 F412L probably damaging Het
Mis18bp1 T C 12: 65,136,826 Y924C probably damaging Het
Mtss1 T C 15: 59,081,515 I5V probably benign Het
Ninl A T 2: 150,955,711 probably null Het
Nrn1 C A 13: 36,730,106 probably null Het
Nts C T 10: 102,482,429 V138M probably damaging Het
Olfr1471 T A 19: 13,445,935 S308T probably benign Het
Pard3 A G 8: 127,426,647 R900G probably damaging Het
Rbfa T C 18: 80,192,835 H233R probably benign Het
Rundc3a T A 11: 102,397,695 probably benign Het
Setdb1 G T 3: 95,337,268 probably null Het
Synpo T A 18: 60,603,800 N358I probably damaging Het
Tnxb A T 17: 34,689,632 T1543S possibly damaging Het
Ugt1a8 T A 1: 88,088,677 Y271N probably benign Het
Vmn2r105 A C 17: 20,227,585 F326V probably damaging Het
Vps13c G A 9: 67,975,851 R3560H probably damaging Het
Vps13d C T 4: 145,075,025 R3510Q probably benign Het
Zcchc8 A T 5: 123,719,483 probably benign Het
Other mutations in Olfr735
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01149:Olfr735 APN 14 50345614 missense probably damaging 0.99
IGL01655:Olfr735 APN 14 50346184 missense probably benign 0.01
IGL02874:Olfr735 APN 14 50346126 missense probably damaging 1.00
R0609:Olfr735 UTSW 14 50345926 missense probably damaging 1.00
R0724:Olfr735 UTSW 14 50345917 missense possibly damaging 0.89
R0839:Olfr735 UTSW 14 50346088 missense probably damaging 0.98
R1766:Olfr735 UTSW 14 50346220 missense probably damaging 1.00
R1799:Olfr735 UTSW 14 50346080 missense probably benign 0.32
R4934:Olfr735 UTSW 14 50345888 missense probably damaging 1.00
R5753:Olfr735 UTSW 14 50345588 missense probably damaging 0.96
R5996:Olfr735 UTSW 14 50345512 missense possibly damaging 0.89
R6555:Olfr735 UTSW 14 50345846 nonsense probably null
R6736:Olfr735 UTSW 14 50345448 missense probably damaging 1.00
R7841:Olfr735 UTSW 14 50345828 missense probably benign 0.09
R7922:Olfr735 UTSW 14 50346415 missense probably benign 0.03
R8190:Olfr735 UTSW 14 50345722 missense probably damaging 0.99
R8308:Olfr735 UTSW 14 50345465 missense probably benign 0.06
R8560:Olfr735 UTSW 14 50346337 missense probably benign 0.12
X0019:Olfr735 UTSW 14 50345806 missense probably damaging 1.00
Posted On2015-12-18