Incidental Mutation 'IGL02838:Nts'
ID 361737
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nts
Ensembl Gene ENSMUSG00000019890
Gene Name neurotensin
Synonyms 5033428E16Rik, NT/N, NTS1, NMN-125, neuromedin N
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02838
Quality Score
Status
Chromosome 10
Chromosomal Location 102317617-102326294 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 102318290 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 138 (V138M)
Ref Sequence ENSEMBL: ENSMUSP00000020040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020040]
AlphaFold Q9D3P9
Predicted Effect probably damaging
Transcript: ENSMUST00000020040
AA Change: V138M

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000020040
Gene: ENSMUSG00000019890
AA Change: V138M

DomainStartEndE-ValueType
Pfam:Pro-NT_NN 3 169 2.4e-77 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a targeted null mutation are viable, fertile, and grossly normal, but display altered responses to antipsychotic drugs. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl4a T C 12: 40,086,303 (GRCm39) E148G probably benign Het
AW551984 A T 9: 39,505,939 (GRCm39) F419L probably damaging Het
Brpf3 G A 17: 29,054,758 (GRCm39) R1100Q probably benign Het
Cacna1e A G 1: 154,321,394 (GRCm39) C1222R probably damaging Het
Cacna2d3 T A 14: 29,022,785 (GRCm39) probably null Het
Ccdc146 T A 5: 21,502,567 (GRCm39) M775L probably benign Het
Ccdc60 A G 5: 116,272,169 (GRCm39) S422P probably damaging Het
Cdh10 A T 15: 18,899,849 (GRCm39) N59Y probably damaging Het
Cfap61 T A 2: 145,789,084 (GRCm39) C29* probably null Het
Fgd5 T A 6: 91,964,655 (GRCm39) M138K probably benign Het
Gpr107 G A 2: 31,104,329 (GRCm39) G545S probably benign Het
Greb1l G A 18: 10,560,430 (GRCm39) A1897T probably damaging Het
Hcls1 A G 16: 36,782,781 (GRCm39) D439G probably damaging Het
Iars1 T A 13: 49,843,965 (GRCm39) N146K possibly damaging Het
Itga5 C T 15: 103,260,036 (GRCm39) A619T probably damaging Het
Maml3 A G 3: 51,597,511 (GRCm39) F412L probably damaging Het
Mis18bp1 T C 12: 65,183,600 (GRCm39) Y924C probably damaging Het
Mtss1 T C 15: 58,953,364 (GRCm39) I5V probably benign Het
Ninl A T 2: 150,797,631 (GRCm39) probably null Het
Nrn1 C A 13: 36,914,080 (GRCm39) probably null Het
Or4q3 A G 14: 50,583,312 (GRCm39) S165P probably damaging Het
Or5b116 T A 19: 13,423,299 (GRCm39) S308T probably benign Het
Pard3 A G 8: 128,153,128 (GRCm39) R900G probably damaging Het
Rbfa T C 18: 80,236,050 (GRCm39) H233R probably benign Het
Rundc3a T A 11: 102,288,521 (GRCm39) probably benign Het
Setdb1 G T 3: 95,244,579 (GRCm39) probably null Het
Synpo T A 18: 60,736,872 (GRCm39) N358I probably damaging Het
Tnxb A T 17: 34,908,606 (GRCm39) T1543S possibly damaging Het
Ugt1a8 T A 1: 88,016,399 (GRCm39) Y271N probably benign Het
Vmn2r105 A C 17: 20,447,847 (GRCm39) F326V probably damaging Het
Vps13c G A 9: 67,883,133 (GRCm39) R3560H probably damaging Het
Vps13d C T 4: 144,801,595 (GRCm39) R3510Q probably benign Het
Zcchc8 A T 5: 123,857,546 (GRCm39) probably benign Het
Other mutations in Nts
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02475:Nts APN 10 102,326,108 (GRCm39) splice site probably benign
IGL02585:Nts APN 10 102,318,329 (GRCm39) missense probably benign 0.01
R1962:Nts UTSW 10 102,320,918 (GRCm39) missense probably damaging 1.00
R4433:Nts UTSW 10 102,320,888 (GRCm39) missense probably benign 0.00
R6063:Nts UTSW 10 102,320,856 (GRCm39) missense probably benign 0.25
R6735:Nts UTSW 10 102,320,859 (GRCm39) missense probably benign
R7640:Nts UTSW 10 102,326,165 (GRCm39) missense possibly damaging 0.74
R7723:Nts UTSW 10 102,320,784 (GRCm39) missense probably damaging 1.00
R8458:Nts UTSW 10 102,320,921 (GRCm39) missense probably damaging 0.98
R8886:Nts UTSW 10 102,320,868 (GRCm39) missense probably benign 0.00
Posted On 2015-12-18