Incidental Mutation 'IGL02838:Zcchc8'
ID 361753
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zcchc8
Ensembl Gene ENSMUSG00000029427
Gene Name zinc finger, CCHC domain containing 8
Synonyms 5730565F05Rik
Accession Numbers

Genbank: NM_027494; MGI: 1917900

Is this an essential gene? Possibly non essential (E-score: 0.379) question?
Stock # IGL02838
Quality Score
Status
Chromosome 5
Chromosomal Location 123698294-123721100 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 123719483 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000142383 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031376] [ENSMUST00000196282] [ENSMUST00000200503]
AlphaFold Q9CYA6
Predicted Effect probably benign
Transcript: ENSMUST00000031376
SMART Domains Protein: ENSMUSP00000031376
Gene: ENSMUSG00000029427

DomainStartEndE-ValueType
low complexity region 33 44 N/A INTRINSIC
coiled coil region 48 83 N/A INTRINSIC
ZnF_C2HC 231 247 4.13e-3 SMART
PSP 286 338 3.04e-27 SMART
low complexity region 410 434 N/A INTRINSIC
low complexity region 464 500 N/A INTRINSIC
low complexity region 520 527 N/A INTRINSIC
low complexity region 613 625 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000196001
Predicted Effect probably benign
Transcript: ENSMUST00000196282
SMART Domains Protein: ENSMUSP00000142363
Gene: ENSMUSG00000029427

DomainStartEndE-ValueType
low complexity region 33 44 N/A INTRINSIC
coiled coil region 48 83 N/A INTRINSIC
ZnF_C2HC 231 247 4.13e-3 SMART
PSP 286 338 3.04e-27 SMART
low complexity region 410 434 N/A INTRINSIC
low complexity region 464 500 N/A INTRINSIC
low complexity region 520 527 N/A INTRINSIC
low complexity region 613 625 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000196333
Predicted Effect probably benign
Transcript: ENSMUST00000198826
Predicted Effect probably benign
Transcript: ENSMUST00000200503
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(12) : Gene trapped(12)

Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl4a T C 12: 40,036,304 E148G probably benign Het
AW551984 A T 9: 39,594,643 F419L probably damaging Het
Brpf3 G A 17: 28,835,784 R1100Q probably benign Het
Cacna1e A G 1: 154,445,648 C1222R probably damaging Het
Cacna2d3 T A 14: 29,300,828 probably null Het
Ccdc146 T A 5: 21,297,569 M775L probably benign Het
Ccdc60 A G 5: 116,134,110 S422P probably damaging Het
Cdh10 A T 15: 18,899,763 N59Y probably damaging Het
Cfap61 T A 2: 145,947,164 C29* probably null Het
Fgd5 T A 6: 91,987,674 M138K probably benign Het
Gpr107 G A 2: 31,214,317 G545S probably benign Het
Greb1l G A 18: 10,560,430 A1897T probably damaging Het
Hcls1 A G 16: 36,962,419 D439G probably damaging Het
Iars T A 13: 49,690,489 N146K possibly damaging Het
Itga5 C T 15: 103,351,609 A619T probably damaging Het
Maml3 A G 3: 51,690,090 F412L probably damaging Het
Mis18bp1 T C 12: 65,136,826 Y924C probably damaging Het
Mtss1 T C 15: 59,081,515 I5V probably benign Het
Ninl A T 2: 150,955,711 probably null Het
Nrn1 C A 13: 36,730,106 probably null Het
Nts C T 10: 102,482,429 V138M probably damaging Het
Olfr1471 T A 19: 13,445,935 S308T probably benign Het
Olfr735 A G 14: 50,345,855 S165P probably damaging Het
Pard3 A G 8: 127,426,647 R900G probably damaging Het
Rbfa T C 18: 80,192,835 H233R probably benign Het
Rundc3a T A 11: 102,397,695 probably benign Het
Setdb1 G T 3: 95,337,268 probably null Het
Synpo T A 18: 60,603,800 N358I probably damaging Het
Tnxb A T 17: 34,689,632 T1543S possibly damaging Het
Ugt1a8 T A 1: 88,088,677 Y271N probably benign Het
Vmn2r105 A C 17: 20,227,585 F326V probably damaging Het
Vps13c G A 9: 67,975,851 R3560H probably damaging Het
Vps13d C T 4: 145,075,025 R3510Q probably benign Het
Other mutations in Zcchc8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01341:Zcchc8 APN 5 123704569 missense probably benign 0.43
IGL01536:Zcchc8 APN 5 123720719 critical splice donor site probably null
IGL02083:Zcchc8 APN 5 123700918 missense probably damaging 1.00
3-1:Zcchc8 UTSW 5 123709481 missense probably damaging 1.00
PIT4515001:Zcchc8 UTSW 5 123700932 missense probably benign 0.23
R0127:Zcchc8 UTSW 5 123707337 missense probably damaging 1.00
R1134:Zcchc8 UTSW 5 123717027 missense probably damaging 1.00
R1604:Zcchc8 UTSW 5 123700658 missense probably benign 0.00
R1744:Zcchc8 UTSW 5 123700373 nonsense probably null
R2216:Zcchc8 UTSW 5 123707403 missense probably damaging 1.00
R2303:Zcchc8 UTSW 5 123700597 missense probably benign 0.00
R2877:Zcchc8 UTSW 5 123700703 missense probably benign 0.05
R2964:Zcchc8 UTSW 5 123720867 missense probably benign 0.00
R2966:Zcchc8 UTSW 5 123720867 missense probably benign 0.00
R6831:Zcchc8 UTSW 5 123700909 missense probably damaging 1.00
R7908:Zcchc8 UTSW 5 123720720 critical splice donor site probably benign
R8738:Zcchc8 UTSW 5 123703007 missense probably damaging 0.99
R8791:Zcchc8 UTSW 5 123707299 missense probably benign 0.06
Posted On 2015-12-18