Incidental Mutation 'IGL02851:Zfy2'
ID361862
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfy2
Ensembl Gene ENSMUSG00000000103
Gene Namezinc finger protein 2, Y-linked
SynonymsZfy-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.058) question?
Stock #IGL02851
Quality Score
Status
ChromosomeY
Chromosomal Location2106015-2170409 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 2106894 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Aspartic acid at position 580 (G580D)
Ref Sequence ENSEMBL: ENSMUSP00000139591 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115891] [ENSMUST00000187148]
Predicted Effect probably benign
Transcript: ENSMUST00000115891
AA Change: G580D

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000111557
Gene: ENSMUSG00000000103
AA Change: G580D

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
Pfam:Zfx_Zfy_act 68 388 1.1e-115 PFAM
ZnF_C2H2 403 425 3.69e-4 SMART
ZnF_C2H2 434 456 1.26e-2 SMART
ZnF_C2H2 491 514 1.41e0 SMART
ZnF_C2H2 520 542 3.69e-4 SMART
ZnF_C2H2 548 571 3.63e-3 SMART
ZnF_C2H2 577 599 1.02e1 SMART
ZnF_C2H2 605 628 3.58e-2 SMART
ZnF_C2H2 634 656 2.95e-3 SMART
ZnF_C2H2 662 685 1.23e0 SMART
ZnF_C2H2 691 713 1.45e-2 SMART
ZnF_C2H2 719 742 1.2e-3 SMART
ZnF_C2H2 748 770 3.34e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000187148
AA Change: G580D

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000139591
Gene: ENSMUSG00000000103
AA Change: G580D

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
Pfam:Zfx_Zfy_act 67 388 2.6e-149 PFAM
ZnF_C2H2 403 425 3.69e-4 SMART
ZnF_C2H2 434 456 1.26e-2 SMART
ZnF_C2H2 491 514 1.41e0 SMART
ZnF_C2H2 520 542 3.69e-4 SMART
ZnF_C2H2 548 571 3.63e-3 SMART
ZnF_C2H2 577 599 1.02e1 SMART
ZnF_C2H2 605 628 3.58e-2 SMART
ZnF_C2H2 634 656 2.95e-3 SMART
ZnF_C2H2 662 685 1.23e0 SMART
ZnF_C2H2 691 713 1.45e-2 SMART
ZnF_C2H2 719 742 1.2e-3 SMART
ZnF_C2H2 748 770 3.34e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akt1 T C 12: 112,657,084 E314G probably damaging Het
Amtn C A 5: 88,381,622 Q106K probably benign Het
Birc6 T C 17: 74,609,189 F1700S probably damaging Het
Brdt T C 5: 107,377,995 S905P possibly damaging Het
Ccdc68 C T 18: 69,947,165 Q194* probably null Het
Cdc27 A G 11: 104,526,981 probably benign Het
Cdh13 A G 8: 118,675,158 T100A probably benign Het
Cdsn A G 17: 35,555,894 H440R possibly damaging Het
Cenpf C A 1: 189,658,030 D1202Y probably damaging Het
Chat C A 14: 32,458,613 V21L probably benign Het
Clca4c-ps T A 3: 144,879,732 noncoding transcript Het
Cst9 A G 2: 148,835,283 I25V probably benign Het
Dennd1b C A 1: 139,168,967 probably benign Het
Dnah9 A G 11: 66,037,744 probably benign Het
Dpp3 T G 19: 4,923,131 Q145P probably benign Het
Elovl5 C T 9: 77,981,502 T217M probably damaging Het
Etl4 T C 2: 20,808,029 V906A possibly damaging Het
Gm10647 C T 9: 66,798,261 probably benign Het
Gm6614 C T 6: 142,003,471 G60R probably damaging Het
Grm5 A G 7: 88,074,710 N736S probably damaging Het
Hectd1 A G 12: 51,767,640 S1638P possibly damaging Het
Hsd3b2 T G 3: 98,716,424 E46A possibly damaging Het
Igkv15-103 A G 6: 68,437,690 T38A probably benign Het
Itpr2 C A 6: 146,385,979 V450L probably damaging Het
Kbtbd12 T C 6: 88,618,329 H173R probably benign Het
Man1a G A 10: 53,919,244 R638W probably damaging Het
Mterf2 A T 10: 85,120,014 S249T probably damaging Het
Muc6 T C 7: 141,648,361 D700G probably damaging Het
Myh13 A G 11: 67,348,916 H764R possibly damaging Het
Myh7b A G 2: 155,628,827 D1065G probably damaging Het
Naip1 C A 13: 100,433,262 W288L probably damaging Het
Naip6 C A 13: 100,300,660 A452S probably benign Het
Nop2 A C 6: 125,144,085 K610T possibly damaging Het
Nop2 G T 6: 125,144,070 G605V probably benign Het
Npvf G A 6: 50,652,690 R107W probably benign Het
Olfr63 T A 17: 33,269,354 I210K probably benign Het
Olfr90 T C 17: 37,086,156 probably null Het
Os9 G A 10: 127,099,393 probably benign Het
Parp4 T C 14: 56,648,869 S1802P unknown Het
Piezo2 G A 18: 63,020,633 S2547F probably benign Het
Plekha7 G T 7: 116,135,178 A1024E probably damaging Het
R3hdm1 T C 1: 128,174,940 probably benign Het
Robo4 T C 9: 37,413,382 S1022P probably damaging Het
Sc5d T C 9: 42,255,394 N283S probably benign Het
Scn10a C T 9: 119,671,608 V202M probably damaging Het
Spag16 T C 1: 70,264,908 I366T possibly damaging Het
Sptbn4 G A 7: 27,426,833 R222C possibly damaging Het
Tlr9 C T 9: 106,224,730 Q407* probably null Het
Trappc12 G A 12: 28,691,406 S768L probably damaging Het
Vmn2r44 A T 7: 8,383,051 L63Q probably damaging Het
Other mutations in Zfy2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02850:Zfy2 APN Y 2106894 missense probably benign 0.01
IGL02850:Zfy2 APN Y 2117188 missense probably benign 0.00
IGL02851:Zfy2 APN Y 2117188 missense probably benign 0.00
IGL02852:Zfy2 APN Y 2106894 missense probably benign 0.01
IGL02852:Zfy2 APN Y 2117188 missense probably benign 0.00
PIT4515001:Zfy2 UTSW Y 2117096 missense probably benign 0.09
R0426:Zfy2 UTSW Y 2107348 missense possibly damaging 0.61
R0490:Zfy2 UTSW Y 2106620 missense possibly damaging 0.89
R1080:Zfy2 UTSW Y 2121645 missense probably benign 0.00
R1513:Zfy2 UTSW Y 2116185 missense probably benign 0.00
R1935:Zfy2 UTSW Y 2121496 missense probably benign 0.02
R1936:Zfy2 UTSW Y 2121496 missense probably benign 0.02
R2358:Zfy2 UTSW Y 2107272 missense possibly damaging 0.61
R4484:Zfy2 UTSW Y 2107351 missense possibly damaging 0.86
R4754:Zfy2 UTSW Y 2121477 missense probably benign 0.02
R4777:Zfy2 UTSW Y 2116194 missense probably benign 0.00
R4812:Zfy2 UTSW Y 2106334 missense probably benign 0.08
R5045:Zfy2 UTSW Y 2107159 missense possibly damaging 0.77
R5363:Zfy2 UTSW Y 2106555 missense possibly damaging 0.95
R6256:Zfy2 UTSW Y 2116267 missense probably benign 0.02
R6618:Zfy2 UTSW Y 2121477 missense probably benign 0.10
R6941:Zfy2 UTSW Y 2121491 missense probably benign 0.02
R7011:Zfy2 UTSW Y 2107127 missense possibly damaging 0.59
R7712:Zfy2 UTSW Y 2121420 missense probably benign 0.05
R7759:Zfy2 UTSW Y 2117083 missense probably benign 0.02
R7985:Zfy2 UTSW Y 2116263 missense probably benign 0.00
R8051:Zfy2 UTSW Y 2117380 intron probably benign
R8218:Zfy2 UTSW Y 2133421 missense unknown
R8345:Zfy2 UTSW Y 2107096 missense possibly damaging 0.95
R8371:Zfy2 UTSW Y 2117168 missense probably benign 0.00
R8830:Zfy2 UTSW Y 2106600 missense possibly damaging 0.60
Posted On2015-12-18