Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02851:Igkv15-103'

361891

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Igkv15-103

Ensembl Gene

ENSMUSG00000076523

Gene Name

immunoglobulin kappa chain variable 15-103

Synonyms

Igk-V32

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02851

Quality Score

Status

Chromosome

Chromosomal Location

68414452-68414909 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 68414674 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 38 (T38A)

Ref Sequence

ENSEMBL: ENSMUSP00000100125 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103324]

AlphaFold

A0A140T8P3

Predicted Effect

probably benign
Transcript: ENSMUST00000103324
AA Change: T38A

PolyPhen 2 Score 0.127 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000100125
Gene: ENSMUSG00000076523
AA Change: T38A

Domain	Start	End	E-Value	Type
low complexity region	2	20	N/A	INTRINSIC
IGv	38	110	1.51e-21	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akt1	T	C	12: 112,623,518 (GRCm39)	E314G	probably damaging	Het
Amtn	C	A	5: 88,529,481 (GRCm39)	Q106K	probably benign	Het
Birc6	T	C	17: 74,916,184 (GRCm39)	F1700S	probably damaging	Het
Brdt	T	C	5: 107,525,861 (GRCm39)	S905P	possibly damaging	Het
Ccdc68	C	T	18: 70,080,236 (GRCm39)	Q194*	probably null	Het
Cdc27	A	G	11: 104,417,807 (GRCm39)		probably benign	Het
Cdh13	A	G	8: 119,401,897 (GRCm39)	T100A	probably benign	Het
Cdsn	A	G	17: 35,866,791 (GRCm39)	H440R	possibly damaging	Het
Cenpf	C	A	1: 189,390,227 (GRCm39)	D1202Y	probably damaging	Het
Chat	C	A	14: 32,180,570 (GRCm39)	V21L	probably benign	Het
Clca4c-ps	T	A	3: 144,585,493 (GRCm39)		noncoding transcript	Het
Cst9	A	G	2: 148,677,203 (GRCm39)	I25V	probably benign	Het
Dennd1b	C	A	1: 139,096,705 (GRCm39)		probably benign	Het
Dnah9	A	G	11: 65,928,570 (GRCm39)		probably benign	Het
Dpp3	T	G	19: 4,973,159 (GRCm39)	Q145P	probably benign	Het
Elovl5	C	T	9: 77,888,784 (GRCm39)	T217M	probably damaging	Het
Etl4	T	C	2: 20,812,840 (GRCm39)	V906A	possibly damaging	Het
Gm10647	C	T	9: 66,705,543 (GRCm39)		probably benign	Het
Grm5	A	G	7: 87,723,918 (GRCm39)	N736S	probably damaging	Het
Hectd1	A	G	12: 51,814,423 (GRCm39)	S1638P	possibly damaging	Het
Hsd3b2	T	G	3: 98,623,740 (GRCm39)	E46A	possibly damaging	Het
Itpr2	C	A	6: 146,287,477 (GRCm39)	V450L	probably damaging	Het
Kbtbd12	T	C	6: 88,595,311 (GRCm39)	H173R	probably benign	Het
Man1a	G	A	10: 53,795,340 (GRCm39)	R638W	probably damaging	Het
Mterf2	A	T	10: 84,955,878 (GRCm39)	S249T	probably damaging	Het
Muc6	T	C	7: 141,234,627 (GRCm39)	D700G	probably damaging	Het
Myh13	A	G	11: 67,239,742 (GRCm39)	H764R	possibly damaging	Het
Myh7b	A	G	2: 155,470,747 (GRCm39)	D1065G	probably damaging	Het
Naip1	C	A	13: 100,569,770 (GRCm39)	W288L	probably damaging	Het
Naip6	C	A	13: 100,437,168 (GRCm39)	A452S	probably benign	Het
Nop2	A	C	6: 125,121,048 (GRCm39)	K610T	possibly damaging	Het
Nop2	G	T	6: 125,121,033 (GRCm39)	G605V	probably benign	Het
Npvf	G	A	6: 50,629,670 (GRCm39)	R107W	probably benign	Het
Or10h28	T	A	17: 33,488,328 (GRCm39)	I210K	probably benign	Het
Or2h2	T	C	17: 37,397,048 (GRCm39)		probably null	Het
Os9	G	A	10: 126,935,262 (GRCm39)		probably benign	Het
Parp4	T	C	14: 56,886,326 (GRCm39)	S1802P	unknown	Het
Piezo2	G	A	18: 63,153,704 (GRCm39)	S2547F	probably benign	Het
Plekha7	G	T	7: 115,734,413 (GRCm39)	A1024E	probably damaging	Het
R3hdm1	T	C	1: 128,102,677 (GRCm39)		probably benign	Het
Robo4	T	C	9: 37,324,678 (GRCm39)	S1022P	probably damaging	Het
Sc5d	T	C	9: 42,166,690 (GRCm39)	N283S	probably benign	Het
Scn10a	C	T	9: 119,500,674 (GRCm39)	V202M	probably damaging	Het
Slco1a8	C	T	6: 141,949,197 (GRCm39)	G60R	probably damaging	Het
Spag16	T	C	1: 70,304,067 (GRCm39)	I366T	possibly damaging	Het
Sptbn4	G	A	7: 27,126,258 (GRCm39)	R222C	possibly damaging	Het
Tlr9	C	T	9: 106,101,929 (GRCm39)	Q407*	probably null	Het
Trappc12	G	A	12: 28,741,405 (GRCm39)	S768L	probably damaging	Het
Vmn2r44	A	T	7: 8,386,050 (GRCm39)	L63Q	probably damaging	Het
Zfy2	C	T	Y: 2,106,894 (GRCm39)	G580D	probably benign	Het
Zfy2	T	A	Y: 2,117,188 (GRCm39)	H213L	probably benign	Het

Other mutations in Igkv15-103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R3957:Igkv15-103	UTSW	6	68,414,903 (GRCm39)	missense	probably benign	0.00
R4165:Igkv15-103	UTSW	6	68,414,824 (GRCm39)	nonsense	probably null
R4494:Igkv15-103	UTSW	6	68,414,780 (GRCm39)	missense	probably benign	0.02
R5998:Igkv15-103	UTSW	6	68,414,489 (GRCm39)	missense	unknown
R6356:Igkv15-103	UTSW	6	68,414,441 (GRCm39)	start gained	probably benign
R6610:Igkv15-103	UTSW	6	68,414,617 (GRCm39)	nonsense	probably null
R8823:Igkv15-103	UTSW	6	68,414,855 (GRCm39)	missense	probably damaging	0.98

Posted On

2015-12-18