Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02852:Zfy2'

361916

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfy2

Ensembl Gene

ENSMUSG00000000103

Gene Name

zinc finger protein 2, Y-linked

Synonyms

Zfy-2

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL02852

Quality Score

Status

Chromosome

Chromosomal Location

2106015-2170409 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 2117188 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 213 (H213L)

Ref Sequence

ENSEMBL: ENSMUSP00000139591 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115891] [ENSMUST00000187148]

AlphaFold

P20662

Predicted Effect

probably benign
Transcript: ENSMUST00000115891
AA Change: H213L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000111557
Gene: ENSMUSG00000000103
AA Change: H213L

Domain	Start	End	E-Value	Type
low complexity region	3	13	N/A	INTRINSIC
Pfam:Zfx_Zfy_act	68	388	1.1e-115	PFAM
ZnF_C2H2	403	425	3.69e-4	SMART
ZnF_C2H2	434	456	1.26e-2	SMART
ZnF_C2H2	491	514	1.41e0	SMART
ZnF_C2H2	520	542	3.69e-4	SMART
ZnF_C2H2	548	571	3.63e-3	SMART
ZnF_C2H2	577	599	1.02e1	SMART
ZnF_C2H2	605	628	3.58e-2	SMART
ZnF_C2H2	634	656	2.95e-3	SMART
ZnF_C2H2	662	685	1.23e0	SMART
ZnF_C2H2	691	713	1.45e-2	SMART
ZnF_C2H2	719	742	1.2e-3	SMART
ZnF_C2H2	748	770	3.34e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000187148
AA Change: H213L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000139591
Gene: ENSMUSG00000000103
AA Change: H213L

Domain	Start	End	E-Value	Type
low complexity region	3	13	N/A	INTRINSIC
Pfam:Zfx_Zfy_act	67	388	2.6e-149	PFAM
ZnF_C2H2	403	425	3.69e-4	SMART
ZnF_C2H2	434	456	1.26e-2	SMART
ZnF_C2H2	491	514	1.41e0	SMART
ZnF_C2H2	520	542	3.69e-4	SMART
ZnF_C2H2	548	571	3.63e-3	SMART
ZnF_C2H2	577	599	1.02e1	SMART
ZnF_C2H2	605	628	3.58e-2	SMART
ZnF_C2H2	634	656	2.95e-3	SMART
ZnF_C2H2	662	685	1.23e0	SMART
ZnF_C2H2	691	713	1.45e-2	SMART
ZnF_C2H2	719	742	1.2e-3	SMART
ZnF_C2H2	748	770	3.34e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bcar1	A	T	8: 111,715,347	L287*	probably null	Het
Birc3	A	G	9: 7,854,483	I402T	probably damaging	Het
Btrc	T	A	19: 45,512,656	L153*	probably null	Het
C2cd3	T	C	7: 100,430,189	F1245L	probably damaging	Het
Cabp7	C	T	11: 4,738,912	R186H	probably damaging	Het
Cdk5r2	T	C	1: 74,856,139	S348P	probably benign	Het
Clca3a2	T	C	3: 144,806,343	D544G	probably damaging	Het
Col6a6	A	C	9: 105,784,073	I279S	probably damaging	Het
Csmd1	T	A	8: 15,895,728	T3562S	probably damaging	Het
Dgkd	T	C	1: 87,935,413	S61P	probably damaging	Het
Dph5	T	A	3: 115,928,671	M266K	possibly damaging	Het
Gm14226	G	A	2: 155,024,921	S266N	possibly damaging	Het
Gm28047	A	G	15: 102,538,218	V400A	possibly damaging	Het
Gm4788	T	C	1: 139,774,016	Y120C	probably damaging	Het
Gucy1a2	A	G	9: 3,759,691	D499G	probably benign	Het
Hoxb7	C	T	11: 96,289,494	T173M	possibly damaging	Het
Kcnn3	T	A	3: 89,609,616	I444N	probably damaging	Het
Kif1b	A	G	4: 149,291,328	I27T	probably damaging	Het
Krtap8-1	A	G	16: 89,487,865	Y15H	probably benign	Het
Myo18b	C	T	5: 112,715,511	V2154I	probably benign	Het
Pcdhb3	A	G	18: 37,302,097	D372G	probably damaging	Het
Pfkp	G	T	13: 6,605,023	P340Q	possibly damaging	Het
Plcd3	C	T	11: 103,073,805	R580Q	probably damaging	Het
Pou5f2	G	A	13: 78,025,059	R40Q	probably benign	Het
Ppara	G	T	15: 85,797,878	M258I	probably benign	Het
Proc	A	G	18: 32,125,155	S246P	probably damaging	Het
Ptpn21	T	C	12: 98,715,195		probably null	Het
Ripor2	T	C	13: 24,695,698	F383S	probably damaging	Het
Rnf39	T	C	17: 36,945,202		probably benign	Het
Sema6c	C	A	3: 95,169,984		probably benign	Het
Slc16a5	A	G	11: 115,469,579	E196G	probably benign	Het
Slco1c1	T	A	6: 141,547,824	L313*	probably null	Het
Slit2	T	C	5: 48,244,672	F789S	probably damaging	Het
Spta1	A	G	1: 174,244,110	M2219V	probably benign	Het
Sqle	A	T	15: 59,326,071	H380L	probably damaging	Het
Tek	T	C	4: 94,855,324	Y859H	probably damaging	Het
Trcg1	A	T	9: 57,241,312	T56S	possibly damaging	Het
Ttc23	T	A	7: 67,667,155		probably benign	Het
Ttn	A	G	2: 76,944,304		probably benign	Het
Uba1y	C	T	Y: 828,841	R550*	probably null	Het
Ubqln4	T	C	3: 88,555,471	V81A	probably damaging	Het
Ugt2b38	C	T	5: 87,411,741	E431K	probably benign	Het
Vmn1r85	T	G	7: 13,085,083	I45L	possibly damaging	Het
Vmn2r68	T	G	7: 85,233,387	S386R	probably damaging	Het
Washc4	A	G	10: 83,583,309	T902A	possibly damaging	Het
Zc3h15	G	A	2: 83,644,671	A7T	possibly damaging	Het
Zdhhc19	A	C	16: 32,497,642	T72P	probably damaging	Het
Zfp729a	A	T	13: 67,619,951	S720T	possibly damaging	Het
Zfp729b	T	C	13: 67,592,823	K441R	probably damaging	Het

Other mutations in Zfy2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02850:Zfy2	APN	Y	2106894	missense	probably benign	0.01
IGL02850:Zfy2	APN	Y	2117188	missense	probably benign	0.00
IGL02851:Zfy2	APN	Y	2106894	missense	probably benign	0.01
IGL02851:Zfy2	APN	Y	2117188	missense	probably benign	0.00
IGL02852:Zfy2	APN	Y	2106894	missense	probably benign	0.01
PIT4515001:Zfy2	UTSW	Y	2117096	missense	probably benign	0.09
R0426:Zfy2	UTSW	Y	2107348	missense	possibly damaging	0.61
R0490:Zfy2	UTSW	Y	2106620	missense	possibly damaging	0.89
R1080:Zfy2	UTSW	Y	2121645	missense	probably benign	0.00
R1513:Zfy2	UTSW	Y	2116185	missense	probably benign	0.00
R1935:Zfy2	UTSW	Y	2121496	missense	probably benign	0.02
R1936:Zfy2	UTSW	Y	2121496	missense	probably benign	0.02
R2358:Zfy2	UTSW	Y	2107272	missense	possibly damaging	0.61
R4484:Zfy2	UTSW	Y	2107351	missense	possibly damaging	0.86
R4754:Zfy2	UTSW	Y	2121477	missense	probably benign	0.02
R4777:Zfy2	UTSW	Y	2116194	missense	probably benign	0.00
R4812:Zfy2	UTSW	Y	2106334	missense	probably benign	0.08
R5045:Zfy2	UTSW	Y	2107159	missense	possibly damaging	0.77
R5363:Zfy2	UTSW	Y	2106555	missense	possibly damaging	0.95
R6256:Zfy2	UTSW	Y	2116267	missense	probably benign	0.02
R6618:Zfy2	UTSW	Y	2121477	missense	probably benign	0.10
R6941:Zfy2	UTSW	Y	2121491	missense	probably benign	0.02
R7011:Zfy2	UTSW	Y	2107127	missense	possibly damaging	0.59
R7712:Zfy2	UTSW	Y	2121420	missense	probably benign	0.05
R7759:Zfy2	UTSW	Y	2117083	missense	probably benign	0.02
R7985:Zfy2	UTSW	Y	2116263	missense	probably benign	0.00
R8051:Zfy2	UTSW	Y	2117380	intron	probably benign
R8218:Zfy2	UTSW	Y	2133421	missense	unknown
R8345:Zfy2	UTSW	Y	2107096	missense	possibly damaging	0.95
R8371:Zfy2	UTSW	Y	2117168	missense	probably benign	0.00
R8830:Zfy2	UTSW	Y	2106600	missense	possibly damaging	0.60
R9448:Zfy2	UTSW	Y	2109904	missense	probably damaging	0.98
R9537:Zfy2	UTSW	Y	2108596	missense

Posted On

2015-12-18