Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02852:Zdhhc19'

361930

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zdhhc19

Ensembl Gene

ENSMUSG00000052363

Gene Name

zinc finger, DHHC domain containing 19

Synonyms

LOC245308

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL02852

Quality Score

Status

Chromosome

Chromosomal Location

32315059-32326032 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 32316460 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 72 (T72P)

Ref Sequence

ENSEMBL: ENSMUSP00000070727 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064192] [ENSMUST00000231510]

AlphaFold

Q810M5

Predicted Effect

probably damaging
Transcript: ENSMUST00000064192
AA Change: T72P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000070727
Gene: ENSMUSG00000052363
AA Change: T72P

Domain	Start	End	E-Value	Type
transmembrane domain	24	46	N/A	INTRINSIC
transmembrane domain	59	81	N/A	INTRINSIC
Pfam:zf-DHHC	107	230	2.5e-32	PFAM
low complexity region	291	306	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160832

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231293

Predicted Effect

probably benign
Transcript: ENSMUST00000231510

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232434

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bcar1	A	T	8: 112,441,979 (GRCm39)	L287*	probably null	Het
Birc2	A	G	9: 7,854,484 (GRCm39)	I402T	probably damaging	Het
Btrc	T	A	19: 45,501,095 (GRCm39)	L153*	probably null	Het
C2cd3	T	C	7: 100,079,396 (GRCm39)	F1245L	probably damaging	Het
Cabp7	C	T	11: 4,688,912 (GRCm39)	R186H	probably damaging	Het
Cdk5r2	T	C	1: 74,895,298 (GRCm39)	S348P	probably benign	Het
Cfhr4	T	C	1: 139,701,754 (GRCm39)	Y120C	probably damaging	Het
Clca3a2	T	C	3: 144,512,104 (GRCm39)	D544G	probably damaging	Het
Col6a6	A	C	9: 105,661,272 (GRCm39)	I279S	probably damaging	Het
Csmd1	T	A	8: 15,945,728 (GRCm39)	T3562S	probably damaging	Het
Dgkd	T	C	1: 87,863,135 (GRCm39)	S61P	probably damaging	Het
Dph5	T	A	3: 115,722,320 (GRCm39)	M266K	possibly damaging	Het
Gm14226	G	A	2: 154,866,841 (GRCm39)	S266N	possibly damaging	Het
Gm28047	A	G	15: 102,446,653 (GRCm39)	V400A	possibly damaging	Het
Gucy1a2	A	G	9: 3,759,691 (GRCm39)	D499G	probably benign	Het
Hoxb7	C	T	11: 96,180,320 (GRCm39)	T173M	possibly damaging	Het
Kcnn3	T	A	3: 89,516,923 (GRCm39)	I444N	probably damaging	Het
Kif1b	A	G	4: 149,375,785 (GRCm39)	I27T	probably damaging	Het
Krtap8-1	A	G	16: 89,284,753 (GRCm39)	Y15H	probably benign	Het
Myo18b	C	T	5: 112,863,377 (GRCm39)	V2154I	probably benign	Het
Pcdhb3	A	G	18: 37,435,150 (GRCm39)	D372G	probably damaging	Het
Pfkp	G	T	13: 6,655,059 (GRCm39)	P340Q	possibly damaging	Het
Plcd3	C	T	11: 102,964,631 (GRCm39)	R580Q	probably damaging	Het
Pou5f2	G	A	13: 78,173,178 (GRCm39)	R40Q	probably benign	Het
Ppara	G	T	15: 85,682,079 (GRCm39)	M258I	probably benign	Het
Proc	A	G	18: 32,258,208 (GRCm39)	S246P	probably damaging	Het
Ptpn21	T	C	12: 98,681,454 (GRCm39)		probably null	Het
Ripor2	T	C	13: 24,879,681 (GRCm39)	F383S	probably damaging	Het
Rnf39	T	C	17: 37,256,094 (GRCm39)		probably benign	Het
Sema6c	C	A	3: 95,077,295 (GRCm39)		probably benign	Het
Slc16a5	A	G	11: 115,360,405 (GRCm39)	E196G	probably benign	Het
Slco1c1	T	A	6: 141,493,550 (GRCm39)	L313*	probably null	Het
Slit2	T	C	5: 48,402,014 (GRCm39)	F789S	probably damaging	Het
Spta1	A	G	1: 174,071,676 (GRCm39)	M2219V	probably benign	Het
Sqle	A	T	15: 59,197,920 (GRCm39)	H380L	probably damaging	Het
Tek	T	C	4: 94,743,561 (GRCm39)	Y859H	probably damaging	Het
Trcg1	A	T	9: 57,148,595 (GRCm39)	T56S	possibly damaging	Het
Ttc23	T	A	7: 67,316,903 (GRCm39)		probably benign	Het
Ttn	A	G	2: 76,774,648 (GRCm39)		probably benign	Het
Uba1y	C	T	Y: 828,841 (GRCm39)	R550*	probably null	Het
Ubqln4	T	C	3: 88,462,778 (GRCm39)	V81A	probably damaging	Het
Ugt2b38	C	T	5: 87,559,600 (GRCm39)	E431K	probably benign	Het
Vmn1r85	T	G	7: 12,819,010 (GRCm39)	I45L	possibly damaging	Het
Vmn2r68	T	G	7: 84,882,595 (GRCm39)	S386R	probably damaging	Het
Washc4	A	G	10: 83,419,173 (GRCm39)	T902A	possibly damaging	Het
Zc3h15	G	A	2: 83,475,015 (GRCm39)	A7T	possibly damaging	Het
Zfp729a	A	T	13: 67,768,070 (GRCm39)	S720T	possibly damaging	Het
Zfp729b	T	C	13: 67,740,942 (GRCm39)	K441R	probably damaging	Het
Zfy2	C	T	Y: 2,106,894 (GRCm39)	G580D	probably benign	Het
Zfy2	T	A	Y: 2,117,188 (GRCm39)	H213L	probably benign	Het

Other mutations in Zdhhc19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02513:Zdhhc19	APN	16	32,318,440 (GRCm39)	missense	probably damaging	0.96
R1163:Zdhhc19	UTSW	16	32,325,258 (GRCm39)	missense	probably benign	0.09
R1903:Zdhhc19	UTSW	16	32,317,231 (GRCm39)	nonsense	probably null
R4617:Zdhhc19	UTSW	16	32,316,494 (GRCm39)	missense	probably damaging	1.00
R4771:Zdhhc19	UTSW	16	32,317,953 (GRCm39)	missense	probably damaging	1.00
R5405:Zdhhc19	UTSW	16	32,325,869 (GRCm39)	missense	possibly damaging	0.65
R6030:Zdhhc19	UTSW	16	32,317,860 (GRCm39)	missense	probably null	1.00
R6030:Zdhhc19	UTSW	16	32,317,860 (GRCm39)	missense	probably null	1.00
R6652:Zdhhc19	UTSW	16	32,316,047 (GRCm39)	missense	probably damaging	1.00
R6802:Zdhhc19	UTSW	16	32,325,176 (GRCm39)	missense	possibly damaging	0.87
R8738:Zdhhc19	UTSW	16	32,317,187 (GRCm39)	missense	probably damaging	1.00
R8944:Zdhhc19	UTSW	16	32,316,500 (GRCm39)	missense	probably damaging	1.00
R9243:Zdhhc19	UTSW	16	32,315,992 (GRCm39)	missense	probably damaging	0.98
R9277:Zdhhc19	UTSW	16	32,316,512 (GRCm39)	missense	probably benign	0.01

Posted On

2015-12-18