Incidental Mutation 'IGL02852:Vmn1r85'
ID361937
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r85
Ensembl Gene ENSMUSG00000070817
Gene Namevomeronasal 1 receptor 85
SynonymsV1rj3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.052) question?
Stock #IGL02852
Quality Score
Status
Chromosome7
Chromosomal Location13084289-13087197 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 13085083 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Leucine at position 45 (I45L)
Ref Sequence ENSEMBL: ENSMUSP00000148178 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094829] [ENSMUST00000209822]
Predicted Effect possibly damaging
Transcript: ENSMUST00000094829
AA Change: I45L

PolyPhen 2 Score 0.698 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000092424
Gene: ENSMUSG00000070817
AA Change: I45L

DomainStartEndE-ValueType
Pfam:TAS2R 1 296 8.4e-18 PFAM
Pfam:V1R 24 298 2.5e-36 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000209822
AA Change: I45L

PolyPhen 2 Score 0.698 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcar1 A T 8: 111,715,347 L287* probably null Het
Birc3 A G 9: 7,854,483 I402T probably damaging Het
Btrc T A 19: 45,512,656 L153* probably null Het
C2cd3 T C 7: 100,430,189 F1245L probably damaging Het
Cabp7 C T 11: 4,738,912 R186H probably damaging Het
Cdk5r2 T C 1: 74,856,139 S348P probably benign Het
Clca3a2 T C 3: 144,806,343 D544G probably damaging Het
Col6a6 A C 9: 105,784,073 I279S probably damaging Het
Csmd1 T A 8: 15,895,728 T3562S probably damaging Het
Dgkd T C 1: 87,935,413 S61P probably damaging Het
Dph5 T A 3: 115,928,671 M266K possibly damaging Het
Gm14226 G A 2: 155,024,921 S266N possibly damaging Het
Gm28047 A G 15: 102,538,218 V400A possibly damaging Het
Gm4788 T C 1: 139,774,016 Y120C probably damaging Het
Gucy1a2 A G 9: 3,759,691 D499G probably benign Het
Hoxb7 C T 11: 96,289,494 T173M possibly damaging Het
Kcnn3 T A 3: 89,609,616 I444N probably damaging Het
Kif1b A G 4: 149,291,328 I27T probably damaging Het
Krtap8-1 A G 16: 89,487,865 Y15H probably benign Het
Myo18b C T 5: 112,715,511 V2154I probably benign Het
Pcdhb3 A G 18: 37,302,097 D372G probably damaging Het
Pfkp G T 13: 6,605,023 P340Q possibly damaging Het
Plcd3 C T 11: 103,073,805 R580Q probably damaging Het
Pou5f2 G A 13: 78,025,059 R40Q probably benign Het
Ppara G T 15: 85,797,878 M258I probably benign Het
Proc A G 18: 32,125,155 S246P probably damaging Het
Ptpn21 T C 12: 98,715,195 probably null Het
Ripor2 T C 13: 24,695,698 F383S probably damaging Het
Rnf39 T C 17: 36,945,202 probably benign Het
Sema6c C A 3: 95,169,984 probably benign Het
Slc16a5 A G 11: 115,469,579 E196G probably benign Het
Slco1c1 T A 6: 141,547,824 L313* probably null Het
Slit2 T C 5: 48,244,672 F789S probably damaging Het
Spta1 A G 1: 174,244,110 M2219V probably benign Het
Sqle A T 15: 59,326,071 H380L probably damaging Het
Tek T C 4: 94,855,324 Y859H probably damaging Het
Trcg1 A T 9: 57,241,312 T56S possibly damaging Het
Ttc23 T A 7: 67,667,155 probably benign Het
Ttn A G 2: 76,944,304 probably benign Het
Uba1y C T Y: 828,841 R550* probably null Het
Ubqln4 T C 3: 88,555,471 V81A probably damaging Het
Ugt2b38 C T 5: 87,411,741 E431K probably benign Het
Vmn2r68 T G 7: 85,233,387 S386R probably damaging Het
Washc4 A G 10: 83,583,309 T902A possibly damaging Het
Zc3h15 G A 2: 83,644,671 A7T possibly damaging Het
Zdhhc19 A C 16: 32,497,642 T72P probably damaging Het
Zfp729a A T 13: 67,619,951 S720T possibly damaging Het
Zfp729b T C 13: 67,592,823 K441R probably damaging Het
Zfy2 C T Y: 2,106,894 G580D probably benign Het
Zfy2 T A Y: 2,117,188 H213L probably benign Het
Other mutations in Vmn1r85
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01099:Vmn1r85 APN 7 13084534 nonsense probably null
IGL01520:Vmn1r85 APN 7 13085154 missense probably damaging 1.00
IGL01803:Vmn1r85 APN 7 13084569 missense probably damaging 0.98
IGL02285:Vmn1r85 APN 7 13084784 missense probably damaging 1.00
IGL03012:Vmn1r85 APN 7 13084765 missense probably benign 0.01
R0391:Vmn1r85 UTSW 7 13084588 missense probably benign 0.01
R0655:Vmn1r85 UTSW 7 13084723 missense probably damaging 1.00
R1142:Vmn1r85 UTSW 7 13084554 missense probably benign 0.01
R1452:Vmn1r85 UTSW 7 13084881 missense probably damaging 1.00
R1942:Vmn1r85 UTSW 7 13084741 missense possibly damaging 0.83
R3760:Vmn1r85 UTSW 7 13085005 missense probably damaging 0.96
R4783:Vmn1r85 UTSW 7 13084861 missense probably damaging 1.00
R4785:Vmn1r85 UTSW 7 13084861 missense probably damaging 1.00
R5373:Vmn1r85 UTSW 7 13084328 nonsense probably null
R6021:Vmn1r85 UTSW 7 13084689 missense probably benign 0.00
R6035:Vmn1r85 UTSW 7 13084927 missense probably damaging 1.00
R6035:Vmn1r85 UTSW 7 13084927 missense probably damaging 1.00
R6834:Vmn1r85 UTSW 7 13084644 missense probably damaging 1.00
R7340:Vmn1r85 UTSW 7 13085146 missense probably damaging 1.00
R7346:Vmn1r85 UTSW 7 13085037 missense probably damaging 0.99
R7836:Vmn1r85 UTSW 7 13084771 missense probably benign 0.06
R7896:Vmn1r85 UTSW 7 13084521 missense probably benign 0.22
Posted On2015-12-18