Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02863:Or10ak9'

362209

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10ak9

Ensembl Gene

ENSMUSG00000073769

Gene Name

olfactory receptor family 10 subfamily AK member 9

Synonyms

MOR259-3P, GA_x6K02T2QD9B-18670866-18669913, Olfr1331

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL02863

Quality Score

Status

Chromosome

Chromosomal Location

118725980-118726933 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 118726083 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Serine at position 34 (I34S)

Ref Sequence

ENSEMBL: ENSMUSP00000154685 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094831] [ENSMUST00000106360] [ENSMUST00000216589]

AlphaFold

K7N684

Predicted Effect

probably benign
Transcript: ENSMUST00000094831
AA Change: I35S

PolyPhen 2 Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000092426
Gene: ENSMUSG00000073769
AA Change: I35S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	308	2.1e-53	PFAM
Pfam:7tm_1	42	291	3.9e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000106360
AA Change: I35S

PolyPhen 2 Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000101967
Gene: ENSMUSG00000073769
AA Change: I35S

Domain	Start	End	E-Value	Type
Pfam:7tm_1	41	290	1.2e-28	PFAM
Pfam:7tm_4	139	283	2.8e-45	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216589
AA Change: I34S

PolyPhen 2 Score 0.524 (Sensitivity: 0.88; Specificity: 0.90)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	T	A	2: 69,115,026 (GRCm39)	H640L	probably damaging	Het
Akr1c19	T	A	13: 4,287,112 (GRCm39)	Y110*	probably null	Het
Alk	T	A	17: 72,204,830 (GRCm39)	E1114V	probably damaging	Het
Anln	A	T	9: 22,287,661 (GRCm39)	D213E	probably damaging	Het
Ano9	T	C	7: 140,688,564 (GRCm39)	N164S	probably benign	Het
Arhgef9	G	A	X: 94,121,110 (GRCm39)	R266C	probably damaging	Het
Armh3	T	A	19: 45,946,850 (GRCm39)	N256Y	probably damaging	Het
Arnt2	C	T	7: 83,917,145 (GRCm39)	R483H	probably damaging	Het
Asxl3	A	T	18: 22,656,541 (GRCm39)	N1517I	probably benign	Het
Baiap3	C	T	17: 25,463,476 (GRCm39)		probably benign	Het
Capn12	T	A	7: 28,582,581 (GRCm39)	V152E	probably damaging	Het
Casq2	A	G	3: 102,051,491 (GRCm39)	T324A	possibly damaging	Het
Cmtm7	T	C	9: 114,592,457 (GRCm39)	T47A	probably benign	Het
Csmd2	A	G	4: 128,415,677 (GRCm39)	S2669G	probably benign	Het
Dnah1	C	T	14: 31,017,250 (GRCm39)	R1520H	probably damaging	Het
Dnah8	T	C	17: 30,988,671 (GRCm39)	C3214R	probably damaging	Het
Elapor2	C	A	5: 9,511,399 (GRCm39)	C920*	probably null	Het
Fbn1	A	T	2: 125,145,176 (GRCm39)	C2688S	possibly damaging	Het
Fgf13	A	G	X: 58,109,029 (GRCm39)	V201A	probably damaging	Het
Ghr	A	T	15: 3,357,584 (GRCm39)	L228*	probably null	Het
Gpr22	A	G	12: 31,760,006 (GRCm39)	C39R	probably benign	Het
Hk1	T	C	10: 62,131,534 (GRCm39)	T274A	possibly damaging	Het
Il18r1	T	A	1: 40,526,167 (GRCm39)	L238M	probably damaging	Het
Lama1	G	A	17: 68,111,531 (GRCm39)	G2261R	probably damaging	Het
Map3k21	A	T	8: 126,654,280 (GRCm39)	E366D	probably benign	Het
Mgat4e	C	T	1: 134,468,896 (GRCm39)	E383K	probably benign	Het
Mrc2	G	A	11: 105,224,446 (GRCm39)		probably benign	Het
Myh13	T	A	11: 67,223,367 (GRCm39)	L229Q	probably damaging	Het
Myo15a	T	A	11: 60,368,953 (GRCm39)	L571Q	probably damaging	Het
Ncoa1	T	A	12: 4,347,513 (GRCm39)	M354L	probably benign	Het
Nomo1	T	C	7: 45,696,340 (GRCm39)	F286S	probably damaging	Het
Ocstamp	A	G	2: 165,239,428 (GRCm39)	F253L	probably damaging	Het
Or8j3c	A	G	2: 86,253,457 (GRCm39)	S188P	probably benign	Het
Osbpl8	T	C	10: 111,120,286 (GRCm39)		probably benign	Het
Parp4	T	C	14: 56,886,243 (GRCm39)	L1774P	unknown	Het
Paxip1	T	C	5: 27,964,393 (GRCm39)	S729G	probably benign	Het
Phlpp1	T	A	1: 106,304,027 (GRCm39)		probably null	Het
Pkd1	G	A	17: 24,788,726 (GRCm39)	G828D	possibly damaging	Het
Ppp4r3c2	C	T	X: 88,796,429 (GRCm39)	P87L	possibly damaging	Het
Raver1	A	G	9: 20,987,267 (GRCm39)	L670P	probably damaging	Het
Rhd	A	G	4: 134,612,621 (GRCm39)	I291V	probably damaging	Het
Rorb	C	T	19: 18,929,617 (GRCm39)	E377K	probably benign	Het
Slc1a5	T	C	7: 16,527,646 (GRCm39)	I314T	probably benign	Het
Synj1	T	C	16: 90,758,322 (GRCm39)	T841A	possibly damaging	Het
Tenm4	T	A	7: 96,522,913 (GRCm39)	L1448H	probably damaging	Het
Tmc3	G	T	7: 83,271,494 (GRCm39)	S882I	probably benign	Het
Tmc3	A	T	7: 83,271,493 (GRCm39)	S882C	possibly damaging	Het
Tmem168	T	C	6: 13,582,917 (GRCm39)	N271D	probably damaging	Het
Uck1	G	A	2: 32,148,334 (GRCm39)	R161C	probably benign	Het
Usp13	A	G	3: 32,973,096 (GRCm39)	I759V	possibly damaging	Het
Vmn1r202	G	A	13: 22,685,640 (GRCm39)	T259I	probably benign	Het
Vmn2r115	G	T	17: 23,578,257 (GRCm39)	V577F	probably damaging	Het

Other mutations in Or10ak9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Or10ak9	APN	4	118,726,484 (GRCm39)	missense	probably damaging	1.00
IGL01314:Or10ak9	APN	4	118,726,328 (GRCm39)	missense	probably benign	0.26
IGL02025:Or10ak9	APN	4	118,726,362 (GRCm39)	missense	probably damaging	1.00
IGL02458:Or10ak9	APN	4	118,726,497 (GRCm39)	missense	possibly damaging	0.83
IGL02793:Or10ak9	APN	4	118,726,794 (GRCm39)	missense	probably damaging	1.00
IGL02827:Or10ak9	APN	4	118,726,157 (GRCm39)	missense	probably damaging	0.99
IGL03125:Or10ak9	APN	4	118,726,118 (GRCm39)	missense	possibly damaging	0.95
R0078:Or10ak9	UTSW	4	118,726,424 (GRCm39)	missense	probably benign
R0152:Or10ak9	UTSW	4	118,726,083 (GRCm39)	missense	possibly damaging	0.89
R0299:Or10ak9	UTSW	4	118,726,613 (GRCm39)	missense	probably benign	0.00
R3881:Or10ak9	UTSW	4	118,726,550 (GRCm39)	missense	probably benign	0.00
R3928:Or10ak9	UTSW	4	118,726,179 (GRCm39)	missense	probably damaging	1.00
R3929:Or10ak9	UTSW	4	118,726,179 (GRCm39)	missense	probably damaging	1.00
R5288:Or10ak9	UTSW	4	118,726,772 (GRCm39)	missense	probably damaging	1.00
R5552:Or10ak9	UTSW	4	118,726,665 (GRCm39)	missense	probably damaging	1.00
R5672:Or10ak9	UTSW	4	118,726,379 (GRCm39)	missense	possibly damaging	0.83
R5773:Or10ak9	UTSW	4	118,726,718 (GRCm39)	missense	probably damaging	0.97
R6117:Or10ak9	UTSW	4	118,726,341 (GRCm39)	missense	probably benign	0.39
R6910:Or10ak9	UTSW	4	118,726,335 (GRCm39)	missense	probably damaging	1.00
R6911:Or10ak9	UTSW	4	118,726,335 (GRCm39)	missense	probably damaging	1.00
R6912:Or10ak9	UTSW	4	118,726,335 (GRCm39)	missense	probably damaging	1.00
R7164:Or10ak9	UTSW	4	118,726,922 (GRCm39)	missense	probably benign	0.30
R7446:Or10ak9	UTSW	4	118,726,019 (GRCm39)	missense	possibly damaging	0.83
R9747:Or10ak9	UTSW	4	118,726,217 (GRCm39)	missense	probably damaging	1.00
T0975:Or10ak9	UTSW	4	118,726,500 (GRCm39)	missense	probably benign	0.02

Posted On

2015-12-18