Incidental Mutation 'IGL02864:Ifng'
ID 362290
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifng
Ensembl Gene ENSMUSG00000055170
Gene Name interferon gamma
Synonyms Ifg, IFN-gamma
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.394) question?
Stock # IGL02864
Quality Score
Status
Chromosome 10
Chromosomal Location 118276951-118281797 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 118278561 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 74 (Y74C)
Ref Sequence ENSEMBL: ENSMUSP00000063800 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068592]
AlphaFold P01580
Predicted Effect probably damaging
Transcript: ENSMUST00000068592
AA Change: Y74C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000063800
Gene: ENSMUSG00000055170
AA Change: Y74C

DomainStartEndE-ValueType
Pfam:IFN-gamma 14 150 8.2e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219775
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220309
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mutants show immune system abnormalities including decreased inflammatory response in one line, and uncontrolled splenocyte proliferation and susceptibility to intracellular pathogens in another. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A G 3: 121,937,080 (GRCm39) R347G probably damaging Het
Actl11 G A 9: 107,806,186 (GRCm39) A170T probably benign Het
Alpk2 T C 18: 65,440,670 (GRCm39) D241G probably benign Het
Arap2 A T 5: 62,835,308 (GRCm39) W745R probably damaging Het
Arhgef7 G A 8: 11,865,247 (GRCm39) V401I possibly damaging Het
Cacna1d A G 14: 29,773,663 (GRCm39) V1709A probably benign Het
Ccl20 T C 1: 83,095,799 (GRCm39) probably null Het
Cd209d C T 8: 3,927,122 (GRCm39) V48I probably benign Het
Cttnbp2 T C 6: 18,374,548 (GRCm39) N1559S probably benign Het
Dnah9 T C 11: 65,951,829 (GRCm39) Y1890C probably damaging Het
Dsel A T 1: 111,786,944 (GRCm39) M1197K probably damaging Het
Dtl A T 1: 191,288,938 (GRCm39) S259T probably benign Het
Fbxw10 G A 11: 62,764,349 (GRCm39) G672D probably damaging Het
Fhod1 C T 8: 106,063,796 (GRCm39) probably benign Het
Gstk1 A G 6: 42,224,687 (GRCm39) Y135C possibly damaging Het
Gtpbp2 G A 17: 46,476,520 (GRCm39) C282Y probably benign Het
Hapln3 A T 7: 78,767,812 (GRCm39) W113R probably benign Het
Kyat1 C A 2: 30,082,089 (GRCm39) probably benign Het
Las1l A T X: 94,991,446 (GRCm39) D308E possibly damaging Het
Mdh1b T A 1: 63,760,762 (GRCm39) T100S probably benign Het
Nrap A T 19: 56,338,806 (GRCm39) M810K probably damaging Het
Otof T C 5: 30,543,685 (GRCm39) D593G probably damaging Het
Pnma5 A T X: 72,079,457 (GRCm39) D408E probably benign Het
Pramel46 G T 5: 95,418,543 (GRCm39) A151E possibly damaging Het
Psen2 T C 1: 180,073,268 (GRCm39) T18A probably benign Het
Ptk7 A T 17: 46,883,659 (GRCm39) V802E probably damaging Het
Setd1b G A 5: 123,297,002 (GRCm39) probably benign Het
Snap91 T C 9: 86,720,141 (GRCm39) N132S possibly damaging Het
Spag9 A G 11: 93,997,487 (GRCm39) H675R probably damaging Het
Tpra1 C A 6: 88,888,868 (GRCm39) P350H probably damaging Het
Trim43a C T 9: 88,470,165 (GRCm39) R324C probably benign Het
Ttn T C 2: 76,566,675 (GRCm39) I28073V probably benign Het
Ttn G T 2: 76,767,095 (GRCm39) H3023Q probably benign Het
Vmn1r21 A G 6: 57,820,661 (GRCm39) V261A probably benign Het
Vwa5b1 G A 4: 138,336,286 (GRCm39) P103S probably benign Het
Wars1 A G 12: 108,848,791 (GRCm39) M52T probably benign Het
Zcchc2 C T 1: 105,943,814 (GRCm39) H460Y probably damaging Het
Zscan12 G T 13: 21,552,730 (GRCm39) V185F probably benign Het
Other mutations in Ifng
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01096:Ifng APN 10 118,281,174 (GRCm39) utr 3 prime probably benign
IGL02351:Ifng APN 10 118,278,410 (GRCm39) missense possibly damaging 0.94
IGL02358:Ifng APN 10 118,278,410 (GRCm39) missense possibly damaging 0.94
IGL02428:Ifng APN 10 118,281,159 (GRCm39) missense probably damaging 0.99
R0295:Ifng UTSW 10 118,277,154 (GRCm39) missense possibly damaging 0.47
R5949:Ifng UTSW 10 118,278,529 (GRCm39) missense probably benign
R9315:Ifng UTSW 10 118,278,588 (GRCm39) missense probably damaging 0.99
R9548:Ifng UTSW 10 118,277,128 (GRCm39) missense probably benign
Posted On 2015-12-18