Incidental Mutation 'IGL02866:Olfr295'
ID362322
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr295
Ensembl Gene ENSMUSG00000059319
Gene Nameolfactory receptor 295
SynonymsMOR220-1, GA_x6K02T2NHDJ-9539243-9538314
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #IGL02866
Quality Score
Status
Chromosome7
Chromosomal Location86583862-86591128 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 86585693 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 139 (C139*)
Ref Sequence ENSEMBL: ENSMUSP00000150377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078447] [ENSMUST00000172965] [ENSMUST00000215365]
Predicted Effect probably null
Transcript: ENSMUST00000078447
AA Change: C139*
SMART Domains Protein: ENSMUSP00000077542
Gene: ENSMUSG00000059319
AA Change: C139*

DomainStartEndE-ValueType
Pfam:7tm_1 39 288 6.1e-26 PFAM
Pfam:7tm_4 137 281 2.2e-40 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000172965
AA Change: C139*
SMART Domains Protein: ENSMUSP00000134371
Gene: ENSMUSG00000057067
AA Change: C139*

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.2e-46 PFAM
Pfam:7tm_1 39 288 2e-20 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215365
AA Change: C139*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 A T 18: 59,048,842 M1118L possibly damaging Het
Ckmt2 A T 13: 91,858,281 L315* probably null Het
Dusp28 T A 1: 92,907,656 I154N probably benign Het
Ect2l A T 10: 18,159,817 I420N probably damaging Het
Erap1 C A 13: 74,667,999 N82K probably damaging Het
Gsdma3 A G 11: 98,629,759 D72G possibly damaging Het
Hectd1 T A 12: 51,790,613 S720C probably damaging Het
Jakmip2 T G 18: 43,552,201 E674A probably benign Het
Kcnt2 T C 1: 140,425,248 S232P probably damaging Het
Kmo T C 1: 175,653,588 S291P probably damaging Het
Kpnb1 A G 11: 97,177,286 V286A probably damaging Het
Ldah T A 12: 8,238,602 V83D probably benign Het
Mrgprb5 T A 7: 48,168,166 I274F probably damaging Het
Mum1l1 T C X: 139,235,004 V97A probably benign Het
Mycbp2 A G 14: 103,129,992 I988T probably damaging Het
Myh3 A G 11: 67,089,023 E596G probably benign Het
Ndufs1 T C 1: 63,147,141 I52V probably benign Het
Nhsl1 G T 10: 18,527,607 D1363Y probably damaging Het
Olfr1450 A G 19: 12,954,355 I255M possibly damaging Het
Olfr585 C A 7: 103,098,383 T214K probably damaging Het
Olfr798 A C 10: 129,625,706 Y118* probably null Het
Pcdhb19 T C 18: 37,499,110 S653P possibly damaging Het
Plcb3 A G 19: 6,957,676 L869P probably damaging Het
Prkdc T A 16: 15,831,327 F3722I probably damaging Het
Ptprd T C 4: 76,050,437 K206R probably damaging Het
Robo3 C A 9: 37,422,306 R703L possibly damaging Het
Tob1 A T 11: 94,214,057 M140L possibly damaging Het
Ubc A T 5: 125,387,422 D280E probably benign Het
Wasf3 C A 5: 146,468,321 Q364K probably benign Het
Other mutations in Olfr295
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01362:Olfr295 APN 7 86585439 missense possibly damaging 0.91
IGL02248:Olfr295 APN 7 86586104 nonsense probably null
IGL02309:Olfr295 APN 7 86585497 missense possibly damaging 0.84
IGL03059:Olfr295 APN 7 86585571 missense probably benign 0.00
IGL03134:Olfr295 UTSW 7 86586012 missense probably damaging 0.99
R1311:Olfr295 UTSW 7 86585953 missense probably damaging 0.96
R1777:Olfr295 UTSW 7 86586064 missense probably benign
R2259:Olfr295 UTSW 7 86585884 missense possibly damaging 0.80
R2379:Olfr295 UTSW 7 86586192 missense probably benign
R5944:Olfr295 UTSW 7 86585278 start codon destroyed probably null 1.00
R6213:Olfr295 UTSW 7 86585277 start codon destroyed probably null 1.00
R6241:Olfr295 UTSW 7 86586037 missense probably benign 0.35
Posted On2015-12-18