Incidental Mutation 'IGL02866:Olfr585'
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Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr585
Ensembl Gene ENSMUSG00000078080
Gene Nameolfactory receptor 585
SynonymsMOR14-4, GA_x6K02T2PBJ9-5809085-5810035
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.052) question?
Stock #IGL02866
Quality Score
Chromosomal Location103097720-103098749 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 103098383 bp
Amino Acid Change Threonine to Lysine at position 214 (T214K)
Ref Sequence ENSEMBL: ENSMUSP00000100476 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104881]
Predicted Effect probably damaging
Transcript: ENSMUST00000104881
AA Change: T214K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000100476
Gene: ENSMUSG00000078080
AA Change: T214K

Pfam:7tm_4 40 318 1.3e-109 PFAM
Pfam:7TM_GPCR_Srsx 45 315 5.9e-6 PFAM
Pfam:7tm_1 50 300 7.9e-23 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 A T 18: 59,048,842 M1118L possibly damaging Het
Ckmt2 A T 13: 91,858,281 L315* probably null Het
Dusp28 T A 1: 92,907,656 I154N probably benign Het
Ect2l A T 10: 18,159,817 I420N probably damaging Het
Erap1 C A 13: 74,667,999 N82K probably damaging Het
Gsdma3 A G 11: 98,629,759 D72G possibly damaging Het
Hectd1 T A 12: 51,790,613 S720C probably damaging Het
Jakmip2 T G 18: 43,552,201 E674A probably benign Het
Kcnt2 T C 1: 140,425,248 S232P probably damaging Het
Kmo T C 1: 175,653,588 S291P probably damaging Het
Kpnb1 A G 11: 97,177,286 V286A probably damaging Het
Ldah T A 12: 8,238,602 V83D probably benign Het
Mrgprb5 T A 7: 48,168,166 I274F probably damaging Het
Mum1l1 T C X: 139,235,004 V97A probably benign Het
Mycbp2 A G 14: 103,129,992 I988T probably damaging Het
Myh3 A G 11: 67,089,023 E596G probably benign Het
Ndufs1 T C 1: 63,147,141 I52V probably benign Het
Nhsl1 G T 10: 18,527,607 D1363Y probably damaging Het
Olfr1450 A G 19: 12,954,355 I255M possibly damaging Het
Olfr295 T A 7: 86,585,693 C139* probably null Het
Olfr798 A C 10: 129,625,706 Y118* probably null Het
Pcdhb19 T C 18: 37,499,110 S653P possibly damaging Het
Plcb3 A G 19: 6,957,676 L869P probably damaging Het
Prkdc T A 16: 15,831,327 F3722I probably damaging Het
Ptprd T C 4: 76,050,437 K206R probably damaging Het
Robo3 C A 9: 37,422,306 R703L possibly damaging Het
Tob1 A T 11: 94,214,057 M140L possibly damaging Het
Ubc A T 5: 125,387,422 D280E probably benign Het
Wasf3 C A 5: 146,468,321 Q364K probably benign Het
Other mutations in Olfr585
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01022:Olfr585 APN 7 103097870 missense probably damaging 1.00
FR4548:Olfr585 UTSW 7 103098309 nonsense probably null
FR4976:Olfr585 UTSW 7 103098309 small insertion probably benign
R0893:Olfr585 UTSW 7 103098434 missense probably benign 0.01
R0926:Olfr585 UTSW 7 103097885 missense probably damaging 1.00
R1486:Olfr585 UTSW 7 103098430 missense probably damaging 1.00
R2031:Olfr585 UTSW 7 103098164 missense probably damaging 0.98
R3852:Olfr585 UTSW 7 103098184 missense probably damaging 0.97
R4849:Olfr585 UTSW 7 103098319 missense possibly damaging 0.95
R5241:Olfr585 UTSW 7 103098317 missense probably benign 0.36
R5668:Olfr585 UTSW 7 103097896 missense probably benign 0.42
R5841:Olfr585 UTSW 7 103097954 missense probably damaging 1.00
R6902:Olfr585 UTSW 7 103098355 missense probably benign 0.12
R7943:Olfr585 UTSW 7 103097946 missense probably damaging 0.98
R8265:Olfr585 UTSW 7 103098097 missense probably benign 0.00
RF003:Olfr585 UTSW 7 103098305
RF003:Olfr585 UTSW 7 103098306 nonsense probably null
RF004:Olfr585 UTSW 7 103098305
RF004:Olfr585 UTSW 7 103098308 small insertion probably benign
RF004:Olfr585 UTSW 7 103098309 nonsense probably null
Posted On2015-12-18