Incidental Mutation 'IGL02866:Mrgprb5'
ID |
362332 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Mrgprb5
|
Ensembl Gene |
ENSMUSG00000070551 |
Gene Name |
MAS-related GPR, member B5 |
Synonyms |
MrgB5 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.051)
|
Stock # |
IGL02866
|
Quality Score |
|
Status
|
|
Chromosome |
7 |
Chromosomal Location |
47817765-47818733 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 47817914 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 274
(I274F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000091953
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094389]
|
AlphaFold |
Q91ZB9 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000094389
AA Change: I274F
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000091953 Gene: ENSMUSG00000070551 AA Change: I274F
Domain | Start | End | E-Value | Type |
low complexity region
|
9 |
21 |
N/A |
INTRINSIC |
Pfam:7TM_GPCR_Srx
|
38 |
217 |
1.4e-8 |
PFAM |
Pfam:7tm_1
|
47 |
210 |
1.7e-7 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 29 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adamts19 |
A |
T |
18: 59,181,914 (GRCm39) |
M1118L |
possibly damaging |
Het |
Ckmt2 |
A |
T |
13: 92,006,400 (GRCm39) |
L315* |
probably null |
Het |
Dusp28 |
T |
A |
1: 92,835,378 (GRCm39) |
I154N |
probably benign |
Het |
Ect2l |
A |
T |
10: 18,035,565 (GRCm39) |
I420N |
probably damaging |
Het |
Erap1 |
C |
A |
13: 74,816,118 (GRCm39) |
N82K |
probably damaging |
Het |
Gsdma3 |
A |
G |
11: 98,520,585 (GRCm39) |
D72G |
possibly damaging |
Het |
Hectd1 |
T |
A |
12: 51,837,396 (GRCm39) |
S720C |
probably damaging |
Het |
Jakmip2 |
T |
G |
18: 43,685,266 (GRCm39) |
E674A |
probably benign |
Het |
Kcnt2 |
T |
C |
1: 140,352,986 (GRCm39) |
S232P |
probably damaging |
Het |
Kmo |
T |
C |
1: 175,481,154 (GRCm39) |
S291P |
probably damaging |
Het |
Kpnb1 |
A |
G |
11: 97,068,112 (GRCm39) |
V286A |
probably damaging |
Het |
Ldah |
T |
A |
12: 8,288,602 (GRCm39) |
V83D |
probably benign |
Het |
Mycbp2 |
A |
G |
14: 103,367,428 (GRCm39) |
I988T |
probably damaging |
Het |
Myh3 |
A |
G |
11: 66,979,849 (GRCm39) |
E596G |
probably benign |
Het |
Ndufs1 |
T |
C |
1: 63,186,300 (GRCm39) |
I52V |
probably benign |
Het |
Nhsl1 |
G |
T |
10: 18,403,355 (GRCm39) |
D1363Y |
probably damaging |
Het |
Or14c41 |
T |
A |
7: 86,234,901 (GRCm39) |
C139* |
probably null |
Het |
Or51f1e |
C |
A |
7: 102,747,590 (GRCm39) |
T214K |
probably damaging |
Het |
Or5b98 |
A |
G |
19: 12,931,719 (GRCm39) |
I255M |
possibly damaging |
Het |
Or6c66 |
A |
C |
10: 129,461,575 (GRCm39) |
Y118* |
probably null |
Het |
Pcdhb19 |
T |
C |
18: 37,632,163 (GRCm39) |
S653P |
possibly damaging |
Het |
Plcb3 |
A |
G |
19: 6,935,044 (GRCm39) |
L869P |
probably damaging |
Het |
Prkdc |
T |
A |
16: 15,649,191 (GRCm39) |
F3722I |
probably damaging |
Het |
Ptprd |
T |
C |
4: 75,968,674 (GRCm39) |
K206R |
probably damaging |
Het |
Pwwp3b |
T |
C |
X: 138,135,753 (GRCm39) |
V97A |
probably benign |
Het |
Robo3 |
C |
A |
9: 37,333,602 (GRCm39) |
R703L |
possibly damaging |
Het |
Tob1 |
A |
T |
11: 94,104,883 (GRCm39) |
M140L |
possibly damaging |
Het |
Ubc |
A |
T |
5: 125,464,486 (GRCm39) |
D280E |
probably benign |
Het |
Wasf3 |
C |
A |
5: 146,405,131 (GRCm39) |
Q364K |
probably benign |
Het |
|
Other mutations in Mrgprb5 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01516:Mrgprb5
|
APN |
7 |
47,818,132 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01662:Mrgprb5
|
APN |
7 |
47,818,172 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01752:Mrgprb5
|
APN |
7 |
47,818,415 (GRCm39) |
missense |
probably benign |
0.22 |
IGL02117:Mrgprb5
|
APN |
7 |
47,818,742 (GRCm39) |
utr 5 prime |
probably benign |
|
IGL03382:Mrgprb5
|
APN |
7 |
47,818,442 (GRCm39) |
missense |
probably benign |
0.01 |
R0545:Mrgprb5
|
UTSW |
7 |
47,818,633 (GRCm39) |
missense |
probably benign |
0.08 |
R1389:Mrgprb5
|
UTSW |
7 |
47,818,078 (GRCm39) |
missense |
probably damaging |
1.00 |
R1939:Mrgprb5
|
UTSW |
7 |
47,818,686 (GRCm39) |
missense |
probably benign |
0.00 |
R2277:Mrgprb5
|
UTSW |
7 |
47,818,579 (GRCm39) |
missense |
probably damaging |
1.00 |
R2367:Mrgprb5
|
UTSW |
7 |
47,818,347 (GRCm39) |
nonsense |
probably null |
|
R2912:Mrgprb5
|
UTSW |
7 |
47,817,815 (GRCm39) |
missense |
probably benign |
|
R2968:Mrgprb5
|
UTSW |
7 |
47,818,317 (GRCm39) |
missense |
probably damaging |
0.98 |
R2969:Mrgprb5
|
UTSW |
7 |
47,818,317 (GRCm39) |
missense |
probably damaging |
0.98 |
R2970:Mrgprb5
|
UTSW |
7 |
47,818,317 (GRCm39) |
missense |
probably damaging |
0.98 |
R3499:Mrgprb5
|
UTSW |
7 |
47,818,661 (GRCm39) |
missense |
probably benign |
0.04 |
R3828:Mrgprb5
|
UTSW |
7 |
47,817,839 (GRCm39) |
missense |
probably benign |
0.01 |
R4590:Mrgprb5
|
UTSW |
7 |
47,817,809 (GRCm39) |
missense |
probably benign |
0.16 |
R4719:Mrgprb5
|
UTSW |
7 |
47,818,526 (GRCm39) |
missense |
probably damaging |
1.00 |
R5263:Mrgprb5
|
UTSW |
7 |
47,817,937 (GRCm39) |
missense |
probably damaging |
0.99 |
R5264:Mrgprb5
|
UTSW |
7 |
47,817,796 (GRCm39) |
missense |
probably benign |
0.10 |
R5644:Mrgprb5
|
UTSW |
7 |
47,817,955 (GRCm39) |
missense |
probably benign |
0.00 |
R6485:Mrgprb5
|
UTSW |
7 |
47,818,525 (GRCm39) |
missense |
probably damaging |
0.99 |
R6713:Mrgprb5
|
UTSW |
7 |
47,818,537 (GRCm39) |
missense |
probably damaging |
0.98 |
R7112:Mrgprb5
|
UTSW |
7 |
47,818,655 (GRCm39) |
missense |
probably benign |
|
R7176:Mrgprb5
|
UTSW |
7 |
47,818,059 (GRCm39) |
missense |
possibly damaging |
0.68 |
R7446:Mrgprb5
|
UTSW |
7 |
47,818,252 (GRCm39) |
missense |
possibly damaging |
0.65 |
R7640:Mrgprb5
|
UTSW |
7 |
47,818,007 (GRCm39) |
missense |
probably benign |
0.00 |
R7831:Mrgprb5
|
UTSW |
7 |
47,817,997 (GRCm39) |
missense |
probably benign |
0.05 |
R9041:Mrgprb5
|
UTSW |
7 |
47,818,509 (GRCm39) |
missense |
probably damaging |
1.00 |
R9314:Mrgprb5
|
UTSW |
7 |
47,818,174 (GRCm39) |
missense |
probably benign |
0.09 |
|
Posted On |
2015-12-18 |