Incidental Mutation 'IGL02867:Zbtb26'
ID 362367
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zbtb26
Ensembl Gene ENSMUSG00000050714
Gene Name zinc finger and BTB domain containing 26
Synonyms A630026F21Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.365) question?
Stock # IGL02867
Quality Score
Status
Chromosome 2
Chromosomal Location 37322180-37333147 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 37326261 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 247 (N247K)
Ref Sequence ENSEMBL: ENSMUSP00000070071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067043] [ENSMUST00000102789] [ENSMUST00000112932]
AlphaFold Q8C8S0
Predicted Effect probably benign
Transcript: ENSMUST00000067043
AA Change: N247K

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000070071
Gene: ENSMUSG00000050714
AA Change: N247K

DomainStartEndE-ValueType
BTB 33 127 4.38e-12 SMART
low complexity region 169 179 N/A INTRINSIC
ZnF_C2H2 273 295 1.36e-2 SMART
ZnF_C2H2 298 320 1.4e-4 SMART
ZnF_C2H2 326 348 2.99e-4 SMART
ZnF_C2H2 354 377 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102789
AA Change: N258K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000099850
Gene: ENSMUSG00000050714
AA Change: N258K

DomainStartEndE-ValueType
BTB 44 138 4.38e-12 SMART
low complexity region 180 190 N/A INTRINSIC
ZnF_C2H2 284 306 1.36e-2 SMART
ZnF_C2H2 309 331 1.4e-4 SMART
ZnF_C2H2 337 359 2.99e-4 SMART
ZnF_C2H2 365 388 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112932
SMART Domains Protein: ENSMUSP00000108554
Gene: ENSMUSG00000066798

DomainStartEndE-ValueType
BTB 33 127 2.67e-16 SMART
Blast:BTB 161 196 1e-5 BLAST
ZnF_C2H2 300 322 7.15e-2 SMART
ZnF_C2H2 325 347 1.58e-3 SMART
ZnF_C2H2 353 375 3.63e-3 SMART
ZnF_C2H2 381 404 8.81e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203522
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf2 T A 5: 24,776,149 (GRCm39) Y310F probably benign Het
Adarb1 C T 10: 77,149,375 (GRCm39) V371I probably benign Het
Antxr2 G T 5: 98,125,509 (GRCm39) H249Q probably benign Het
Arel1 A T 12: 84,981,097 (GRCm39) N303K probably benign Het
Bloc1s6 T C 2: 122,584,604 (GRCm39) Y60H probably damaging Het
Ccdc125 A T 13: 100,820,790 (GRCm39) probably benign Het
Cxcl16 A T 11: 70,349,892 (GRCm39) Y45N possibly damaging Het
Dnajb3 T A 1: 88,133,249 (GRCm39) Q51L probably benign Het
Ear10 A G 14: 44,160,726 (GRCm39) F34L probably damaging Het
Fgf11 A G 11: 69,690,498 (GRCm39) S100P possibly damaging Het
Fpgs G A 2: 32,575,891 (GRCm39) probably benign Het
Fyb1 A T 15: 6,609,527 (GRCm39) Q33H probably damaging Het
Ints3 G T 3: 90,300,143 (GRCm39) H925N probably damaging Het
Krt16 T C 11: 100,138,402 (GRCm39) K249E probably damaging Het
Lrp2 A T 2: 69,382,794 (GRCm39) S30R possibly damaging Het
Naa35 T C 13: 59,756,668 (GRCm39) probably benign Het
Or11g27 A G 14: 50,770,970 (GRCm39) I34V probably benign Het
Or1e22 A G 11: 73,376,817 (GRCm39) Y278H probably damaging Het
Or8g2b A G 9: 39,751,533 (GRCm39) M268V probably benign Het
Osbpl6 A G 2: 76,426,214 (GRCm39) probably benign Het
Pramel6 A T 2: 87,340,736 (GRCm39) Q356L probably damaging Het
Prima1 A G 12: 103,163,575 (GRCm39) V132A probably benign Het
Psme1 A G 14: 55,817,383 (GRCm39) probably benign Het
Rdh11 A G 12: 79,235,828 (GRCm39) V40A possibly damaging Het
Rin1 C T 19: 5,103,198 (GRCm39) R485C probably damaging Het
Rnf40 C A 7: 127,190,601 (GRCm39) S255* probably null Het
Spata24 C A 18: 35,789,805 (GRCm39) R194L probably benign Het
Spata31h1 C T 10: 82,119,654 (GRCm39) S482N probably damaging Het
Tas1r1 A T 4: 152,112,735 (GRCm39) S773T probably damaging Het
Trdv5 G T 14: 54,386,429 (GRCm39) probably benign Het
Trpc3 A C 3: 36,694,850 (GRCm39) D701E probably benign Het
Vim A G 2: 13,585,491 (GRCm39) R424G probably damaging Het
Vmn1r216 A C 13: 23,283,649 (GRCm39) T111P probably damaging Het
Zfp629 T G 7: 127,209,203 (GRCm39) probably benign Het
Other mutations in Zbtb26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00579:Zbtb26 APN 2 37,326,454 (GRCm39) missense possibly damaging 0.82
IGL00899:Zbtb26 APN 2 37,326,270 (GRCm39) nonsense probably null
IGL01598:Zbtb26 APN 2 37,326,283 (GRCm39) missense probably damaging 1.00
IGL01940:Zbtb26 APN 2 37,325,987 (GRCm39) missense possibly damaging 0.93
IGL02152:Zbtb26 APN 2 37,326,703 (GRCm39) missense possibly damaging 0.95
IGL02889:Zbtb26 APN 2 37,326,261 (GRCm39) missense probably benign 0.00
IGL03081:Zbtb26 APN 2 37,326,612 (GRCm39) missense possibly damaging 0.67
R0138:Zbtb26 UTSW 2 37,326,053 (GRCm39) missense probably benign 0.16
R0328:Zbtb26 UTSW 2 37,326,807 (GRCm39) missense possibly damaging 0.81
R0927:Zbtb26 UTSW 2 37,326,337 (GRCm39) missense possibly damaging 0.91
R1671:Zbtb26 UTSW 2 37,326,377 (GRCm39) missense probably benign 0.00
R1813:Zbtb26 UTSW 2 37,326,347 (GRCm39) missense possibly damaging 0.68
R1896:Zbtb26 UTSW 2 37,326,347 (GRCm39) missense possibly damaging 0.68
R2128:Zbtb26 UTSW 2 37,326,563 (GRCm39) missense probably benign 0.00
R2374:Zbtb26 UTSW 2 37,326,497 (GRCm39) missense probably benign
R4050:Zbtb26 UTSW 2 37,327,000 (GRCm39) start codon destroyed probably null 0.46
R4631:Zbtb26 UTSW 2 37,326,968 (GRCm39) missense probably benign 0.00
R4940:Zbtb26 UTSW 2 37,326,781 (GRCm39) missense probably damaging 0.98
R5071:Zbtb26 UTSW 2 37,325,941 (GRCm39) missense probably benign 0.26
R6348:Zbtb26 UTSW 2 37,325,687 (GRCm39) missense probably benign 0.43
R6962:Zbtb26 UTSW 2 37,326,106 (GRCm39) missense possibly damaging 0.71
R6990:Zbtb26 UTSW 2 37,326,557 (GRCm39) missense probably benign 0.00
R7261:Zbtb26 UTSW 2 37,326,667 (GRCm39) missense possibly damaging 0.71
R7981:Zbtb26 UTSW 2 37,326,887 (GRCm39) missense possibly damaging 0.51
R8013:Zbtb26 UTSW 2 37,327,013 (GRCm39) critical splice acceptor site probably null
R8014:Zbtb26 UTSW 2 37,327,013 (GRCm39) critical splice acceptor site probably null
R8872:Zbtb26 UTSW 2 37,326,913 (GRCm39) missense probably damaging 0.99
R8876:Zbtb26 UTSW 2 37,326,896 (GRCm39) missense probably benign
R8905:Zbtb26 UTSW 2 37,326,927 (GRCm39) missense probably benign 0.00
Posted On 2015-12-18