Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02868:Tas2r107'

362412

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r107

Ensembl Gene

ENSMUSG00000053389

Gene Name

taste receptor, type 2, member 107

Synonyms

T2R4, Tas2r7, mGR06, STC 5-1, mt2r43, T2R07

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL02868

Quality Score

Status

Chromosome

Chromosomal Location

131659118-131660149 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 131659286 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 267 (T267A)

Ref Sequence

ENSEMBL: ENSMUSP00000067082 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065781]

Predicted Effect

probably benign
Transcript: ENSMUST00000065781
AA Change: T267A

PolyPhen 2 Score 0.110 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000067082
Gene: ENSMUSG00000053389
AA Change: T267A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	297	4e-106	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap4	A	G	X: 73,900,402	I224T	probably benign	Het
Atp12a	A	G	14: 56,384,182	D758G	probably damaging	Het
Clca3b	C	A	3: 144,827,564	G569V	probably damaging	Het
Dlgap4	G	A	2: 156,700,896	R73Q	probably damaging	Het
Efcc1	C	T	6: 87,751,761		probably benign	Het
Eno3	T	A	11: 70,662,000	V369E	probably damaging	Het
Espl1	T	A	15: 102,313,990	C1022*	probably null	Het
Gm884	A	T	11: 103,615,139	L2001H	probably benign	Het
Grhl3	T	C	4: 135,554,604	D319G	probably damaging	Het
Huwe1	G	A	X: 151,908,833	R2538H	possibly damaging	Het
Ms4a4d	T	A	19: 11,550,282	I51N	probably damaging	Het
Mtmr9	T	C	14: 63,524,139	N522S	probably benign	Het
Nfe2l1	A	G	11: 96,820,140	I133T	probably damaging	Het
Ninl	A	G	2: 150,937,054	Y1296H	probably benign	Het
Nipal3	A	G	4: 135,466,871	S284P	probably damaging	Het
Olfr1009	A	T	2: 85,721,575	T57S	probably benign	Het
Olfr1286	A	T	2: 111,420,493	F153I	possibly damaging	Het
Pramel5	G	T	4: 144,271,352	N440K	probably benign	Het
Rabep1	T	C	11: 70,874,746	V12A	probably benign	Het
Rbm5	G	T	9: 107,749,700		probably benign	Het
Ric3	T	C	7: 109,054,419	E155G	probably damaging	Het
Slc12a7	T	A	13: 73,806,388	M897K	probably benign	Het
Slc39a8	G	T	3: 135,856,026	A169S	probably damaging	Het
Stxbp2	A	T	8: 3,641,971	I538F	probably benign	Het
Synrg	G	A	11: 83,987,050		probably benign	Het
Tead3	G	T	17: 28,333,095	Y354*	probably null	Het
Trim3	T	C	7: 105,613,032	K579R	possibly damaging	Het
Uaca	A	T	9: 60,863,637	K362M	probably damaging	Het
Vmn2r94	A	G	17: 18,244,054	I658T	possibly damaging	Het
Vps13b	C	T	15: 35,884,519	P3113S	probably benign	Het
Zfp251	A	G	15: 76,854,534	S115P	probably damaging	Het
Zfp683	G	A	4: 134,055,866	V214M	probably benign	Het

Other mutations in Tas2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02749:Tas2r107	APN	6	131659954	missense	probably damaging	1.00
IGL02751:Tas2r107	APN	6	131659484	missense	probably damaging	1.00
IGL02943:Tas2r107	APN	6	131659406	missense	probably damaging	0.99
R1564:Tas2r107	UTSW	6	131659822	missense	probably damaging	0.96
R1905:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1906:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R1907:Tas2r107	UTSW	6	131659988	missense	probably benign	0.20
R2185:Tas2r107	UTSW	6	131659603	missense	probably damaging	0.98
R3014:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R3824:Tas2r107	UTSW	6	131659330	missense	probably benign	0.00
R4465:Tas2r107	UTSW	6	131660009	missense	probably benign	0.30
R5058:Tas2r107	UTSW	6	131659742	missense	probably damaging	1.00
R5646:Tas2r107	UTSW	6	131659708	missense	probably benign	0.02
R5975:Tas2r107	UTSW	6	131659780	missense	probably benign	0.02
R6008:Tas2r107	UTSW	6	131659912	missense	possibly damaging	0.82
R6144:Tas2r107	UTSW	6	131660003	missense	possibly damaging	0.87
R6451:Tas2r107	UTSW	6	131660014	missense	possibly damaging	0.81
R6662:Tas2r107	UTSW	6	131659489	missense	possibly damaging	0.82
R6702:Tas2r107	UTSW	6	131659384	missense	probably benign	0.12
R7032:Tas2r107	UTSW	6	131659190	missense	possibly damaging	0.62
R7635:Tas2r107	UTSW	6	131659600	missense	possibly damaging	0.92
R8303:Tas2r107	UTSW	6	131659622	missense	probably benign	0.00

Posted On

2015-12-18