Incidental Mutation 'R0362:Myo9b'
| ID |
36248 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo9b
|
| Ensembl Gene |
ENSMUSG00000004677 |
| Gene Name |
myosin IXb |
| Synonyms |
|
| MMRRC Submission |
038568-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.852)
|
| Stock # |
R0362 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
71725358-71813357 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 71800414 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 990
(W990R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129220
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071935]
[ENSMUST00000168839]
[ENSMUST00000170242]
[ENSMUST00000212935]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000071935
AA Change: W990R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000071827
Gene: ENSMUSG00000004677
AA Change: W990R
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
15 |
114 |
3.7e-30 |
SMART |
|
MYSc
|
140 |
954 |
N/A |
SMART |
|
IQ
|
955 |
977 |
1.2e-3 |
SMART |
|
IQ
|
978 |
1000 |
1.6e-5 |
SMART |
|
IQ
|
1001 |
1022 |
4.3e-5 |
SMART |
|
IQ
|
1023 |
1045 |
8.4e-5 |
SMART |
|
low complexity region
|
1050 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1127 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1211 |
1222 |
N/A |
INTRINSIC |
|
low complexity region
|
1232 |
1246 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1247 |
1323 |
3e-19 |
BLAST |
|
low complexity region
|
1348 |
1359 |
N/A |
INTRINSIC |
|
coiled coil region
|
1563 |
1590 |
N/A |
INTRINSIC |
|
C1
|
1591 |
1639 |
1.7e-14 |
SMART |
|
RhoGAP
|
1668 |
1843 |
4.7e-71 |
SMART |
|
coiled coil region
|
1901 |
1925 |
N/A |
INTRINSIC |
|
low complexity region
|
1940 |
1952 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168839
AA Change: W990R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000131635
Gene: ENSMUSG00000004677
AA Change: W990R
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
15 |
114 |
5.79e-28 |
SMART |
|
MYSc
|
140 |
954 |
N/A |
SMART |
|
IQ
|
955 |
977 |
2.46e-1 |
SMART |
|
IQ
|
978 |
1000 |
3.35e-3 |
SMART |
|
IQ
|
1001 |
1022 |
8.84e-3 |
SMART |
|
IQ
|
1023 |
1045 |
1.77e-2 |
SMART |
|
low complexity region
|
1050 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1127 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1211 |
1222 |
N/A |
INTRINSIC |
|
low complexity region
|
1234 |
1257 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1258 |
1334 |
3e-19 |
BLAST |
|
low complexity region
|
1361 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1581 |
1601 |
N/A |
INTRINSIC |
|
C1
|
1605 |
1653 |
3.58e-12 |
SMART |
|
RhoGAP
|
1682 |
1857 |
7.78e-69 |
SMART |
|
coiled coil region
|
1915 |
1939 |
N/A |
INTRINSIC |
|
low complexity region
|
1954 |
1966 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170242
AA Change: W990R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129220
Gene: ENSMUSG00000004677
AA Change: W990R
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
15 |
114 |
5.79e-28 |
SMART |
|
MYSc
|
140 |
954 |
N/A |
SMART |
|
IQ
|
955 |
977 |
2.46e-1 |
SMART |
|
IQ
|
978 |
1000 |
3.35e-3 |
SMART |
|
IQ
|
1001 |
1022 |
8.84e-3 |
SMART |
|
IQ
|
1023 |
1045 |
1.77e-2 |
SMART |
|
low complexity region
|
1050 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1127 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1211 |
1222 |
N/A |
INTRINSIC |
|
low complexity region
|
1234 |
1257 |
N/A |
INTRINSIC |
|
Blast:MYSc
|
1258 |
1334 |
3e-19 |
BLAST |
|
low complexity region
|
1361 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1581 |
1601 |
N/A |
INTRINSIC |
|
C1
|
1605 |
1653 |
3.58e-12 |
SMART |
|
RhoGAP
|
1682 |
1857 |
7.78e-69 |
SMART |
|
coiled coil region
|
1931 |
1955 |
N/A |
INTRINSIC |
|
low complexity region
|
1970 |
1982 |
N/A |
INTRINSIC |
|
low complexity region
|
1992 |
2003 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000212412
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000212935
AA Change: W991R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Meta Mutation Damage Score |
0.9095 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.6%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
99% (104/105) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutants breed normal, but shows defect in macrophage motility and chemotaxis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932414N04Rik |
A |
G |
2: 68,563,261 (GRCm39) |
Q401R |
probably benign |
Het |
| Acp3 |
A |
G |
9: 104,191,626 (GRCm39) |
F220S |
probably damaging |
Het |
| Adam7 |
A |
G |
14: 68,747,105 (GRCm39) |
|
probably benign |
Het |
| Adamts6 |
A |
G |
13: 104,526,584 (GRCm39) |
|
probably null |
Het |
| Ascc3 |
T |
C |
10: 50,625,051 (GRCm39) |
|
probably benign |
Het |
| Atg10 |
T |
C |
13: 91,189,109 (GRCm39) |
|
probably null |
Het |
| Atm |
T |
C |
9: 53,370,138 (GRCm39) |
I2325V |
possibly damaging |
Het |
| Btnl9 |
C |
T |
11: 49,060,443 (GRCm39) |
R435H |
possibly damaging |
Het |
| Ccdc180 |
A |
G |
4: 45,923,551 (GRCm39) |
K1111E |
probably damaging |
Het |
| Ciao2b |
T |
C |
8: 105,368,222 (GRCm39) |
D34G |
probably null |
Het |
| Col11a2 |
T |
A |
17: 34,281,420 (GRCm39) |
|
probably null |
Het |
| Ctcfl |
A |
G |
2: 172,960,236 (GRCm39) |
W116R |
probably damaging |
Het |
| Ctsk |
A |
T |
3: 95,408,255 (GRCm39) |
Y37F |
probably damaging |
Het |
| Daam2 |
G |
C |
17: 49,787,813 (GRCm39) |
|
probably null |
Het |
| Dcdc2b |
T |
C |
4: 129,504,031 (GRCm39) |
|
probably null |
Het |
| Ddx28 |
C |
T |
8: 106,737,926 (GRCm39) |
R44Q |
probably damaging |
Het |
| Dhx29 |
T |
A |
13: 113,099,393 (GRCm39) |
N1139K |
probably benign |
Het |
| Dnah17 |
A |
T |
11: 117,989,365 (GRCm39) |
M1281K |
probably benign |
Het |
| Dnah6 |
T |
C |
6: 73,185,592 (GRCm39) |
S110G |
probably benign |
Het |
| Drc7 |
T |
C |
8: 95,799,483 (GRCm39) |
Y553H |
probably benign |
Het |
| Dync2h1 |
T |
C |
9: 7,005,487 (GRCm39) |
|
probably null |
Het |
| Ecm1 |
A |
G |
3: 95,644,369 (GRCm39) |
I152T |
possibly damaging |
Het |
| Edc4 |
C |
G |
8: 106,613,407 (GRCm39) |
P307R |
probably damaging |
Het |
| Eeig2 |
C |
T |
3: 108,887,497 (GRCm39) |
E256K |
probably benign |
Het |
| Egr1 |
A |
G |
18: 34,996,366 (GRCm39) |
T383A |
possibly damaging |
Het |
| Eml2 |
A |
G |
7: 18,924,731 (GRCm39) |
|
probably null |
Het |
| Eno4 |
A |
G |
19: 58,932,056 (GRCm39) |
|
probably benign |
Het |
| Erbb4 |
A |
T |
1: 68,369,429 (GRCm39) |
I404K |
probably damaging |
Het |
| Exoc7 |
G |
T |
11: 116,186,488 (GRCm39) |
T310K |
probably benign |
Het |
| Fam83e |
G |
T |
7: 45,376,393 (GRCm39) |
V369L |
probably benign |
Het |
| Fancc |
A |
T |
13: 63,545,970 (GRCm39) |
I91K |
possibly damaging |
Het |
| Fbn1 |
T |
C |
2: 125,151,697 (GRCm39) |
Q2519R |
probably damaging |
Het |
| Fhod3 |
T |
A |
18: 25,223,133 (GRCm39) |
C826* |
probably null |
Het |
| Foxi3 |
A |
G |
6: 70,933,612 (GRCm39) |
D33G |
probably benign |
Het |
| Gcn1 |
T |
C |
5: 115,714,167 (GRCm39) |
|
probably benign |
Het |
| Gm14221 |
T |
C |
2: 160,410,310 (GRCm39) |
|
noncoding transcript |
Het |
| Golga4 |
T |
A |
9: 118,384,853 (GRCm39) |
H630Q |
probably benign |
Het |
| Gpat4 |
T |
C |
8: 23,670,949 (GRCm39) |
S88G |
probably benign |
Het |
| Gucy2d |
A |
T |
7: 98,092,892 (GRCm39) |
S90C |
probably damaging |
Het |
| Has2 |
A |
C |
15: 56,545,057 (GRCm39) |
C182G |
probably damaging |
Het |
| Heatr5a |
A |
T |
12: 51,935,644 (GRCm39) |
S1647R |
probably damaging |
Het |
| Ifi35 |
T |
C |
11: 101,348,038 (GRCm39) |
V48A |
probably benign |
Het |
| Lig1 |
T |
A |
7: 13,030,730 (GRCm39) |
|
probably benign |
Het |
| Magi2 |
A |
G |
5: 19,432,573 (GRCm39) |
K96R |
probably damaging |
Het |
| Map7d1 |
G |
T |
4: 126,128,787 (GRCm39) |
P462Q |
probably damaging |
Het |
| Mdn1 |
A |
T |
4: 32,746,439 (GRCm39) |
|
probably null |
Het |
| Mfsd4a |
A |
T |
1: 131,987,013 (GRCm39) |
V105E |
probably damaging |
Het |
| Mrpl53 |
C |
T |
6: 83,086,526 (GRCm39) |
R77C |
probably damaging |
Het |
| Mtnr1b |
C |
T |
9: 15,785,600 (GRCm39) |
V53M |
probably damaging |
Het |
| Myt1 |
A |
T |
2: 181,405,186 (GRCm39) |
|
probably benign |
Het |
| Nf1 |
C |
T |
11: 79,427,704 (GRCm39) |
A1766V |
probably damaging |
Het |
| Nlrp3 |
T |
C |
11: 59,439,623 (GRCm39) |
V400A |
possibly damaging |
Het |
| Nup205 |
T |
A |
6: 35,173,649 (GRCm39) |
|
probably null |
Het |
| Nxf1 |
T |
C |
19: 8,741,515 (GRCm39) |
|
probably null |
Het |
| Or7a36 |
A |
T |
10: 78,820,220 (GRCm39) |
M199L |
probably benign |
Het |
| P4hb |
T |
C |
11: 120,454,162 (GRCm39) |
K311E |
probably benign |
Het |
| Pafah1b1 |
T |
C |
11: 74,574,457 (GRCm39) |
N243S |
probably benign |
Het |
| Parp8 |
G |
A |
13: 117,061,504 (GRCm39) |
Q141* |
probably null |
Het |
| Pkd2l2 |
A |
C |
18: 34,568,380 (GRCm39) |
D543A |
probably benign |
Het |
| Pld5 |
A |
T |
1: 175,803,146 (GRCm39) |
L311* |
probably null |
Het |
| Plekha5 |
G |
A |
6: 140,537,473 (GRCm39) |
R646K |
possibly damaging |
Het |
| Plpp5 |
A |
T |
8: 26,214,219 (GRCm39) |
T144S |
probably benign |
Het |
| Ppp6r3 |
A |
G |
19: 3,528,285 (GRCm39) |
L542S |
probably damaging |
Het |
| Prkar2b |
A |
T |
12: 32,037,973 (GRCm39) |
|
probably null |
Het |
| Psmg1 |
A |
T |
16: 95,789,171 (GRCm39) |
S129T |
possibly damaging |
Het |
| Radil |
T |
C |
5: 142,529,582 (GRCm39) |
D38G |
probably benign |
Het |
| Ric1 |
T |
C |
19: 29,578,411 (GRCm39) |
|
probably null |
Het |
| Rp1l1 |
T |
A |
14: 64,268,515 (GRCm39) |
L1367* |
probably null |
Het |
| Rxfp1 |
A |
T |
3: 79,645,100 (GRCm39) |
M1K |
probably null |
Het |
| Serpina6 |
G |
T |
12: 103,618,208 (GRCm39) |
L202I |
probably damaging |
Het |
| Simc1 |
T |
C |
13: 54,676,280 (GRCm39) |
I98T |
probably damaging |
Het |
| Slc17a6 |
A |
G |
7: 51,308,519 (GRCm39) |
Y281C |
probably damaging |
Het |
| Slc26a11 |
T |
A |
11: 119,270,767 (GRCm39) |
|
probably benign |
Het |
| Slc34a1 |
T |
A |
13: 55,550,711 (GRCm39) |
|
probably null |
Het |
| Slfn10-ps |
T |
A |
11: 82,926,600 (GRCm39) |
|
noncoding transcript |
Het |
| Sohlh2 |
A |
G |
3: 55,115,163 (GRCm39) |
N383D |
probably damaging |
Het |
| Spag6 |
T |
A |
2: 18,715,302 (GRCm39) |
L27H |
probably damaging |
Het |
| Sptlc3 |
A |
G |
2: 139,388,475 (GRCm39) |
|
probably benign |
Het |
| St3gal4 |
T |
A |
9: 34,964,469 (GRCm39) |
K199* |
probably null |
Het |
| Stat5a |
T |
A |
11: 100,772,909 (GRCm39) |
D712E |
probably benign |
Het |
| Stmn2 |
A |
T |
3: 8,610,750 (GRCm39) |
D78V |
probably damaging |
Het |
| Stpg1 |
C |
T |
4: 135,233,777 (GRCm39) |
P20S |
possibly damaging |
Het |
| Taf2 |
A |
T |
15: 54,909,325 (GRCm39) |
V640E |
probably damaging |
Het |
| Tbce |
T |
C |
13: 14,172,747 (GRCm39) |
E501G |
probably benign |
Het |
| Tecpr2 |
A |
G |
12: 110,935,374 (GRCm39) |
S1398G |
probably damaging |
Het |
| Tenm4 |
T |
A |
7: 96,421,242 (GRCm39) |
Y598* |
probably null |
Het |
| Ticrr |
A |
G |
7: 79,327,088 (GRCm39) |
S599G |
probably damaging |
Het |
| Tnc |
A |
C |
4: 63,935,679 (GRCm39) |
V419G |
probably damaging |
Het |
| Trappc1 |
C |
A |
11: 69,216,402 (GRCm39) |
P110T |
probably benign |
Het |
| Trbv12-2 |
C |
T |
6: 41,095,993 (GRCm39) |
|
probably benign |
Het |
| Ttbk2 |
A |
T |
2: 120,576,264 (GRCm39) |
N835K |
possibly damaging |
Het |
| Tubgcp5 |
A |
G |
7: 55,450,432 (GRCm39) |
D181G |
probably damaging |
Het |
| Tut1 |
T |
C |
19: 8,932,891 (GRCm39) |
Y75H |
possibly damaging |
Het |
| Ulk2 |
C |
A |
11: 61,678,412 (GRCm39) |
C769F |
probably benign |
Het |
| Vdac1 |
T |
C |
11: 52,265,800 (GRCm39) |
|
probably benign |
Het |
| Vmn2r124 |
T |
C |
17: 18,284,486 (GRCm39) |
|
probably null |
Het |
| Vps8 |
T |
C |
16: 21,426,977 (GRCm39) |
|
probably benign |
Het |
| Wdr35 |
T |
C |
12: 9,045,625 (GRCm39) |
|
probably benign |
Het |
| Zdhhc7 |
T |
A |
8: 120,813,386 (GRCm39) |
E141V |
probably null |
Het |
| Zfp12 |
C |
A |
5: 143,230,978 (GRCm39) |
S435Y |
probably damaging |
Het |
| Zfp974 |
A |
T |
7: 27,626,819 (GRCm39) |
|
probably benign |
Het |
| Zfyve9 |
T |
A |
4: 108,538,166 (GRCm39) |
K1033N |
probably damaging |
Het |
| Zswim8 |
T |
A |
14: 20,772,013 (GRCm39) |
S1572T |
possibly damaging |
Het |
|
| Other mutations in Myo9b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00163:Myo9b
|
APN |
8 |
71,801,379 (GRCm39) |
missense |
probably benign |
|
|
IGL01020:Myo9b
|
APN |
8 |
71,804,644 (GRCm39) |
missense |
probably benign |
|
|
IGL01479:Myo9b
|
APN |
8 |
71,811,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01704:Myo9b
|
APN |
8 |
71,812,286 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01761:Myo9b
|
APN |
8 |
71,801,796 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01766:Myo9b
|
APN |
8 |
71,743,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01834:Myo9b
|
APN |
8 |
71,807,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01834:Myo9b
|
APN |
8 |
71,808,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01838:Myo9b
|
APN |
8 |
71,787,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02318:Myo9b
|
APN |
8 |
71,806,768 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02333:Myo9b
|
APN |
8 |
71,811,637 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02340:Myo9b
|
APN |
8 |
71,743,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02514:Myo9b
|
APN |
8 |
71,743,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02593:Myo9b
|
APN |
8 |
71,743,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03075:Myo9b
|
APN |
8 |
71,807,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Myo9b
|
APN |
8 |
71,801,418 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
avantgarde
|
UTSW |
8 |
71,796,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Freaky
|
UTSW |
8 |
71,743,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
iconoclastic
|
UTSW |
8 |
71,743,119 (GRCm39) |
missense |
probably benign |
0.37 |
|
unconventional
|
UTSW |
8 |
71,801,241 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4418001:Myo9b
|
UTSW |
8 |
71,775,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4651001:Myo9b
|
UTSW |
8 |
71,795,456 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0023:Myo9b
|
UTSW |
8 |
71,786,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Myo9b
|
UTSW |
8 |
71,776,493 (GRCm39) |
splice site |
probably benign |
|
|
R0103:Myo9b
|
UTSW |
8 |
71,776,493 (GRCm39) |
splice site |
probably benign |
|
|
R0144:Myo9b
|
UTSW |
8 |
71,798,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0207:Myo9b
|
UTSW |
8 |
71,807,869 (GRCm39) |
splice site |
probably benign |
|
|
R0226:Myo9b
|
UTSW |
8 |
71,806,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0227:Myo9b
|
UTSW |
8 |
71,796,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0244:Myo9b
|
UTSW |
8 |
71,774,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0277:Myo9b
|
UTSW |
8 |
71,808,596 (GRCm39) |
splice site |
probably benign |
|
|
R0689:Myo9b
|
UTSW |
8 |
71,783,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0844:Myo9b
|
UTSW |
8 |
71,743,119 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1051:Myo9b
|
UTSW |
8 |
71,808,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Myo9b
|
UTSW |
8 |
71,743,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Myo9b
|
UTSW |
8 |
71,743,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1526:Myo9b
|
UTSW |
8 |
71,808,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1544:Myo9b
|
UTSW |
8 |
71,743,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1565:Myo9b
|
UTSW |
8 |
71,767,836 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1645:Myo9b
|
UTSW |
8 |
71,775,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1745:Myo9b
|
UTSW |
8 |
71,806,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1820:Myo9b
|
UTSW |
8 |
71,786,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2037:Myo9b
|
UTSW |
8 |
71,743,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Myo9b
|
UTSW |
8 |
71,743,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2056:Myo9b
|
UTSW |
8 |
71,812,334 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2129:Myo9b
|
UTSW |
8 |
71,786,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Myo9b
|
UTSW |
8 |
71,780,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2869:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2869:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2871:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2871:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2872:Myo9b
|
UTSW |
8 |
71,743,610 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2872:Myo9b
|
UTSW |
8 |
71,743,610 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2873:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2874:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2920:Myo9b
|
UTSW |
8 |
71,778,501 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2926:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2939:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2940:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3033:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3040:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3689:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3691:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Myo9b
|
UTSW |
8 |
71,801,241 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4194:Myo9b
|
UTSW |
8 |
71,812,268 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4258:Myo9b
|
UTSW |
8 |
71,808,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4457:Myo9b
|
UTSW |
8 |
71,743,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4478:Myo9b
|
UTSW |
8 |
71,743,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4496:Myo9b
|
UTSW |
8 |
71,786,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4544:Myo9b
|
UTSW |
8 |
71,780,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4580:Myo9b
|
UTSW |
8 |
71,767,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4736:Myo9b
|
UTSW |
8 |
71,809,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5068:Myo9b
|
UTSW |
8 |
71,801,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5124:Myo9b
|
UTSW |
8 |
71,808,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5194:Myo9b
|
UTSW |
8 |
71,801,733 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5296:Myo9b
|
UTSW |
8 |
71,786,032 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5528:Myo9b
|
UTSW |
8 |
71,775,918 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5664:Myo9b
|
UTSW |
8 |
71,812,526 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5677:Myo9b
|
UTSW |
8 |
71,796,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5680:Myo9b
|
UTSW |
8 |
71,743,016 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5982:Myo9b
|
UTSW |
8 |
71,801,040 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6344:Myo9b
|
UTSW |
8 |
71,780,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6352:Myo9b
|
UTSW |
8 |
71,801,055 (GRCm39) |
missense |
probably benign |
|
|
R6352:Myo9b
|
UTSW |
8 |
71,801,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6411:Myo9b
|
UTSW |
8 |
71,775,599 (GRCm39) |
nonsense |
probably null |
|
|
R6425:Myo9b
|
UTSW |
8 |
71,786,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6505:Myo9b
|
UTSW |
8 |
71,808,501 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6743:Myo9b
|
UTSW |
8 |
71,804,803 (GRCm39) |
splice site |
probably null |
|
|
R6811:Myo9b
|
UTSW |
8 |
71,809,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Myo9b
|
UTSW |
8 |
71,775,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6954:Myo9b
|
UTSW |
8 |
71,743,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7124:Myo9b
|
UTSW |
8 |
71,786,345 (GRCm39) |
nonsense |
probably null |
|
|
R7255:Myo9b
|
UTSW |
8 |
71,743,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7293:Myo9b
|
UTSW |
8 |
71,778,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7342:Myo9b
|
UTSW |
8 |
71,808,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7451:Myo9b
|
UTSW |
8 |
71,804,832 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7482:Myo9b
|
UTSW |
8 |
71,795,442 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7508:Myo9b
|
UTSW |
8 |
71,807,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7957:Myo9b
|
UTSW |
8 |
71,807,405 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8062:Myo9b
|
UTSW |
8 |
71,774,457 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8108:Myo9b
|
UTSW |
8 |
71,800,986 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8197:Myo9b
|
UTSW |
8 |
71,743,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8274:Myo9b
|
UTSW |
8 |
71,812,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8686:Myo9b
|
UTSW |
8 |
71,786,966 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8731:Myo9b
|
UTSW |
8 |
71,806,486 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8924:Myo9b
|
UTSW |
8 |
71,801,675 (GRCm39) |
missense |
probably benign |
|
|
R9056:Myo9b
|
UTSW |
8 |
71,804,906 (GRCm39) |
missense |
probably benign |
0.17 |
|
R9117:Myo9b
|
UTSW |
8 |
71,800,451 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9151:Myo9b
|
UTSW |
8 |
71,807,871 (GRCm39) |
splice site |
probably benign |
|
|
R9315:Myo9b
|
UTSW |
8 |
71,801,811 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9332:Myo9b
|
UTSW |
8 |
71,812,246 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9364:Myo9b
|
UTSW |
8 |
71,808,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Myo9b
|
UTSW |
8 |
71,811,629 (GRCm39) |
missense |
probably benign |
|
|
R9581:Myo9b
|
UTSW |
8 |
71,812,543 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9600:Myo9b
|
UTSW |
8 |
71,743,075 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
X0066:Myo9b
|
UTSW |
8 |
71,776,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Myo9b
|
UTSW |
8 |
71,743,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTCCTGAAGGAGACAGAGCGTC -3'
(R):5'- AGGAGAGGAACTCTGAGTTGGTCAC -3'
Sequencing Primer
(F):5'- ACAGAGCGTCAGACCCTG -3'
(R):5'- TGAGTTGGTCACAGCCATC -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation