Incidental Mutation 'IGL02870:Agmat'
ID362543
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Agmat
Ensembl Gene ENSMUSG00000040706
Gene Nameagmatine ureohydrolase (agmatinase)
Synonyms5033405N08Rik
Accession Numbers

Genbank: NM_001081408; MGI: 1923236

Is this an essential gene? Probably non essential (E-score: 0.111) question?
Stock #IGL02870
Quality Score
Status
Chromosome4
Chromosomal Location141746672-141759263 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 141746942 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Asparagine at position 45 (H45N)
Ref Sequence ENSEMBL: ENSMUSP00000040853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038161]
Predicted Effect probably benign
Transcript: ENSMUST00000038161
AA Change: H45N

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000040853
Gene: ENSMUSG00000040706
AA Change: H45N

DomainStartEndE-ValueType
low complexity region 44 62 N/A INTRINSIC
Pfam:Arginase 77 351 9.8e-85 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 C T 13: 81,563,732 V1042M probably benign Het
Akap13 T A 7: 75,609,188 V520D probably damaging Het
Ccser1 T A 6: 61,311,292 N146K probably damaging Het
Cdhr4 T A 9: 107,998,064 probably null Het
Col4a1 G A 8: 11,221,375 T753I probably benign Het
Cyp3a59 T C 5: 146,098,184 I224T probably benign Het
Ddx19a G T 8: 110,983,626 P114Q probably damaging Het
Eftud2 A G 11: 102,862,626 V275A probably damaging Het
Fgd6 T C 10: 94,045,164 S627P probably damaging Het
Flywch1 C T 17: 23,755,902 G541D probably damaging Het
Grk2 T C 19: 4,290,402 D317G probably damaging Het
H2-M5 T C 17: 36,989,033 E83G probably benign Het
Hltf T C 3: 20,099,873 F658L probably damaging Het
Hmmr G T 11: 40,714,075 Q390K possibly damaging Het
Lama1 G A 17: 67,804,536 G2261R probably damaging Het
Nsd1 A T 13: 55,313,603 T2548S probably benign Het
Olfr341 G A 2: 36,480,031 A33V probably benign Het
P3h1 C T 4: 119,247,571 R684W probably damaging Het
Peli2 G A 14: 48,256,265 V315M probably damaging Het
Pfkl T A 10: 78,000,839 K115* probably null Het
Plcxd1 A G 5: 110,101,405 T33A probably damaging Het
Ranbp17 A G 11: 33,243,262 S931P probably damaging Het
Retsat T C 6: 72,607,024 Y500H probably damaging Het
Rfx8 C T 1: 39,683,711 V249I possibly damaging Het
Runx1t1 A T 4: 13,889,867 I599L unknown Het
Sardh A T 2: 27,235,491 I337N possibly damaging Het
Serpinb7 A T 1: 107,450,287 M237L probably damaging Het
Slc35f1 A G 10: 52,933,207 S97G possibly damaging Het
Stab1 T C 14: 31,139,397 D2520G probably benign Het
Tnfrsf11b C T 15: 54,256,027 V184M probably benign Het
Trpv4 A T 5: 114,625,056 V764E probably damaging Het
Tsc22d1 C A 14: 76,417,617 A430E probably benign Het
Ttn T C 2: 76,750,605 R23315G probably damaging Het
Txnrd1 A G 10: 82,895,979 I478M probably benign Het
Ush2a T C 1: 188,678,358 V2401A probably benign Het
Vill T C 9: 119,061,899 L191P probably damaging Het
Vmn1r30 A G 6: 58,435,370 V159A probably benign Het
Washc4 T A 10: 83,585,876 N939K probably benign Het
Wdfy3 A G 5: 101,855,471 V2926A probably damaging Het
Wdr7 T C 18: 63,791,843 S966P probably benign Het
Zfp12 C A 5: 143,245,331 T471N probably damaging Het
Other mutations in Agmat
AlleleSourceChrCoordTypePredicted EffectPPH Score
3-1:Agmat UTSW 4 141749582 missense probably damaging 1.00
3-1:Agmat UTSW 4 141749610 missense possibly damaging 0.49
R1635:Agmat UTSW 4 141747069 missense probably damaging 1.00
R2103:Agmat UTSW 4 141755903 missense probably damaging 0.97
R2215:Agmat UTSW 4 141749588 missense probably benign 0.01
R3767:Agmat UTSW 4 141755962 missense probably benign 0.00
R4379:Agmat UTSW 4 141757491 missense probably benign 0.10
R5422:Agmat UTSW 4 141755833 missense probably damaging 1.00
R5640:Agmat UTSW 4 141755823 missense probably damaging 1.00
R5750:Agmat UTSW 4 141749687 missense probably benign 0.03
R6728:Agmat UTSW 4 141749586 missense probably benign 0.00
R6891:Agmat UTSW 4 141755881 missense probably benign 0.01
R7293:Agmat UTSW 4 141755935 nonsense probably null
R7298:Agmat UTSW 4 141746964 missense possibly damaging 0.90
R7361:Agmat UTSW 4 141746852 missense probably benign 0.23
R7585:Agmat UTSW 4 141749745 missense probably benign 0.09
Z1177:Agmat UTSW 4 141746979 missense possibly damaging 0.72
Posted On2015-12-18