Incidental Mutation 'IGL02871:Pga5'
ID362586
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pga5
Ensembl Gene ENSMUSG00000024738
Gene Namepepsinogen 5, group I
Synonyms1110035E17Rik, Pepf, pepsinogen A5
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02871
Quality Score
Status
Chromosome19
Chromosomal Location10668956-10678071 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 10671780 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000025647 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025647]
Predicted Effect probably benign
Transcript: ENSMUST00000025647
SMART Domains Protein: ENSMUSP00000025647
Gene: ENSMUSG00000024738

DomainStartEndE-ValueType
Pfam:A1_Propeptide 16 44 1.1e-13 PFAM
Pfam:Asp 73 386 1.1e-112 PFAM
Pfam:TAXi_N 74 229 7.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225016
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225135
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl15 C A 13: 114,154,838 H179Q probably benign Het
Bin3 T A 14: 70,128,905 C72* probably null Het
Brca2 C T 5: 150,542,552 T1927I probably benign Het
Cap2 A G 13: 46,525,492 D26G probably benign Het
Casz1 T G 4: 148,944,319 S1074A possibly damaging Het
Chd5 C T 4: 152,376,685 P1244L probably damaging Het
Exosc9 A G 3: 36,565,281 N408S probably benign Het
Ezr G A 17: 6,742,390 Q352* probably null Het
Fbxl4 T A 4: 22,386,213 D273E probably benign Het
Gm3269 A T 14: 4,841,042 N193I probably damaging Het
Haus8 A T 8: 71,256,494 M90K probably benign Het
Igkv5-39 A T 6: 69,900,506 S89T probably benign Het
Nlrp4b A C 7: 10,715,265 D465A probably benign Het
Nsf A G 11: 103,862,056 probably benign Het
Nt5c1b G A 12: 10,381,325 M409I probably damaging Het
Olfr1195 T A 2: 88,683,084 Y216F probably damaging Het
Olfr1248 T C 2: 89,618,160 I11V probably benign Het
Olfr199 T A 16: 59,216,374 K80* probably null Het
Pigk T A 3: 152,766,516 I355K probably damaging Het
Prom1 T C 5: 44,029,676 Y404C probably damaging Het
Ptprs T C 17: 56,447,443 E199G probably damaging Het
Sec24c T C 14: 20,692,882 S935P probably benign Het
Slc22a13 T C 9: 119,196,011 T200A probably benign Het
Svep1 T A 4: 58,100,871 I1264L probably benign Het
Tcf7l2 T A 19: 55,918,997 C349S probably damaging Het
Thbs2 T C 17: 14,685,786 H284R probably benign Het
Vmn2r19 C T 6: 123,336,083 S704L probably damaging Het
Vmn2r50 A G 7: 10,047,787 Y344H possibly damaging Het
Other mutations in Pga5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01660:Pga5 APN 19 10675092 missense probably damaging 1.00
IGL02037:Pga5 APN 19 10676701 missense probably benign 0.01
IGL02069:Pga5 APN 19 10669399 missense possibly damaging 0.76
IGL02197:Pga5 APN 19 10671913 splice site probably benign
R0238:Pga5 UTSW 19 10669453 missense probably damaging 1.00
R0238:Pga5 UTSW 19 10669453 missense probably damaging 1.00
R0239:Pga5 UTSW 19 10669453 missense probably damaging 1.00
R0239:Pga5 UTSW 19 10669453 missense probably damaging 1.00
R1573:Pga5 UTSW 19 10673837 missense probably benign 0.13
R1941:Pga5 UTSW 19 10669456 splice site probably null
R4354:Pga5 UTSW 19 10674826 critical splice donor site probably null
R4568:Pga5 UTSW 19 10671852 missense probably damaging 1.00
R5119:Pga5 UTSW 19 10676689 missense probably benign 0.00
R5738:Pga5 UTSW 19 10669660 missense probably benign 0.05
R5864:Pga5 UTSW 19 10675149 missense probably damaging 1.00
R6176:Pga5 UTSW 19 10671785 splice site probably null
R6270:Pga5 UTSW 19 10674861 missense probably benign
R6990:Pga5 UTSW 19 10669415 missense probably benign 0.03
Z1176:Pga5 UTSW 19 10669159 missense probably damaging 1.00
Posted On2015-12-18