Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02873:Ifna4'

362587

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna4

Ensembl Gene

ENSMUSG00000070904

Gene Name

interferon alpha 4

Synonyms

Ifa4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL02873

Quality Score

Status

Chromosome

Chromosomal Location

88760098-88760658 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88760423 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 109 (F109S)

Ref Sequence

ENSEMBL: ENSMUSP00000092581 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094973]

AlphaFold

P07351

Predicted Effect

probably damaging
Transcript: ENSMUST00000094973
AA Change: F109S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000092581
Gene: ENSMUSG00000070904
AA Change: F109S

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
IFabd	59	171	3.26e-56	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933405O20Rik	A	T	7: 50,249,431 (GRCm39)	H155L	probably damaging	Het
5830462I19Rik	G	A	9: 110,203,446 (GRCm39)		probably benign	Het
Ankib1	T	A	5: 3,822,619 (GRCm39)	Q29L	probably damaging	Het
Arid5b	A	T	10: 67,937,780 (GRCm39)	M449K	probably benign	Het
Atp1a1	A	G	3: 101,483,894 (GRCm39)	V1017A	probably benign	Het
Cfap52	G	T	11: 67,822,608 (GRCm39)	T421K	probably damaging	Het
Chd8	A	T	14: 52,459,970 (GRCm39)	I780N	probably damaging	Het
Cubn	T	C	2: 13,299,181 (GRCm39)	D3164G	probably benign	Het
Cyp4f37	A	T	17: 32,844,142 (GRCm39)	Q82L	probably benign	Het
Eml6	T	A	11: 29,830,700 (GRCm39)	D265V	probably benign	Het
Gm14393	T	C	2: 174,903,595 (GRCm39)	D104G	possibly damaging	Het
Gpat2	T	C	2: 127,273,675 (GRCm39)	V271A	probably benign	Het
Il27ra	T	C	8: 84,758,164 (GRCm39)	S529G	probably benign	Het
Jag2	A	G	12: 112,874,122 (GRCm39)	L1011P	probably benign	Het
Kif7	A	G	7: 79,356,507 (GRCm39)	L728P	probably damaging	Het
Klhl21	T	C	4: 152,099,817 (GRCm39)	V509A	probably benign	Het
Map2k4	T	A	11: 65,610,400 (GRCm39)	N92I	probably damaging	Het
Myo15a	A	T	11: 60,374,308 (GRCm39)	D1288V	probably damaging	Het
Or4k37	T	C	2: 111,159,217 (GRCm39)	V151A	probably benign	Het
Or5g25	C	A	2: 85,478,096 (GRCm39)	A190S	possibly damaging	Het
Paip1	T	A	13: 119,582,348 (GRCm39)	F275L	possibly damaging	Het
Plxnd1	T	C	6: 115,936,937 (GRCm39)	D1624G	probably damaging	Het
Ppwd1	C	A	13: 104,346,261 (GRCm39)	D465Y	probably damaging	Het
Resf1	T	C	6: 149,228,538 (GRCm39)	L528P	probably damaging	Het
Rftn1	A	C	17: 50,476,180 (GRCm39)		probably benign	Het
Scn1b	T	A	7: 30,817,182 (GRCm39)	Y180F	probably damaging	Het
Slc16a4	A	G	3: 107,208,111 (GRCm39)	D207G	probably benign	Het
Slc2a3	T	C	6: 122,717,373 (GRCm39)	T28A	probably damaging	Het
Slc47a1	G	A	11: 61,253,643 (GRCm39)		probably benign	Het
Spata1	A	T	3: 146,193,122 (GRCm39)	V123D	possibly damaging	Het
Stard9	T	C	2: 120,544,288 (GRCm39)	V4469A	probably damaging	Het
Trmu	T	A	15: 85,781,033 (GRCm39)		probably null	Het
Trrap	T	A	5: 144,777,889 (GRCm39)		probably benign	Het
Ttn	T	C	2: 76,726,475 (GRCm39)		probably benign	Het
Tubgcp6	T	C	15: 88,988,027 (GRCm39)	D974G	probably benign	Het
Tyw1	C	T	5: 130,364,171 (GRCm39)	R621C	probably benign	Het
Usp7	A	T	16: 8,513,058 (GRCm39)		probably benign	Het
Zfp39	T	C	11: 58,781,848 (GRCm39)	K305E	probably benign	Het
Zfp692	C	T	11: 58,199,765 (GRCm39)	T118M	probably damaging	Het

Other mutations in Ifna4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00664:Ifna4	APN	4	88,760,336 (GRCm39)	missense	probably benign	0.15
IGL01781:Ifna4	APN	4	88,760,389 (GRCm39)	missense	probably damaging	1.00
IGL02259:Ifna4	APN	4	88,760,293 (GRCm39)	missense	probably damaging	0.98
PIT4453001:Ifna4	UTSW	4	88,760,191 (GRCm39)	missense	probably damaging	1.00
R1464:Ifna4	UTSW	4	88,760,237 (GRCm39)	missense	probably damaging	0.99
R1464:Ifna4	UTSW	4	88,760,237 (GRCm39)	missense	probably damaging	0.99
R1956:Ifna4	UTSW	4	88,760,311 (GRCm39)	missense	probably damaging	0.99
R4724:Ifna4	UTSW	4	88,760,519 (GRCm39)	missense	probably benign
R4726:Ifna4	UTSW	4	88,760,519 (GRCm39)	missense	probably benign
R4727:Ifna4	UTSW	4	88,760,519 (GRCm39)	missense	probably benign
R4728:Ifna4	UTSW	4	88,760,519 (GRCm39)	missense	probably benign
R4751:Ifna4	UTSW	4	88,760,185 (GRCm39)	missense	probably benign	0.04
R5885:Ifna4	UTSW	4	88,760,599 (GRCm39)	missense	probably damaging	1.00
R7673:Ifna4	UTSW	4	88,760,309 (GRCm39)	missense	possibly damaging	0.90

Posted On

2015-12-18