Incidental Mutation 'IGL02873:Zfp39'
ID 362601
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp39
Ensembl Gene ENSMUSG00000037001
Gene Name zinc finger protein 39
Synonyms Zfp-39, CTfin33
Accession Numbers
Essential gene? Probably non essential (E-score: 0.153) question?
Stock # IGL02873
Quality Score
Status
Chromosome 11
Chromosomal Location 58778979-58795051 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58781848 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 305 (K305E)
Ref Sequence ENSEMBL: ENSMUSP00000099764 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102703]
AlphaFold Q02525
Predicted Effect probably benign
Transcript: ENSMUST00000102703
AA Change: K305E

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000099764
Gene: ENSMUSG00000037001
AA Change: K305E

DomainStartEndE-ValueType
KRAB 59 119 8.23e-34 SMART
low complexity region 171 180 N/A INTRINSIC
ZnF_C2H2 298 320 9.58e-3 SMART
ZnF_C2H2 326 347 2.2e2 SMART
ZnF_C2H2 353 373 1.18e2 SMART
ZnF_C2H2 409 431 8.34e-3 SMART
ZnF_C2H2 437 459 7.26e-3 SMART
ZnF_C2H2 465 487 1.53e-1 SMART
ZnF_C2H2 493 515 9.08e-4 SMART
ZnF_C2H2 521 543 2.61e-4 SMART
ZnF_C2H2 549 571 1.12e-3 SMART
ZnF_C2H2 577 599 4.94e-5 SMART
ZnF_C2H2 605 627 5.14e-3 SMART
ZnF_C2H2 633 655 1.38e-3 SMART
ZnF_C2H2 661 683 6.78e-3 SMART
ZnF_C2H2 689 711 5.14e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132394
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405O20Rik A T 7: 50,249,431 (GRCm39) H155L probably damaging Het
5830462I19Rik G A 9: 110,203,446 (GRCm39) probably benign Het
Ankib1 T A 5: 3,822,619 (GRCm39) Q29L probably damaging Het
Arid5b A T 10: 67,937,780 (GRCm39) M449K probably benign Het
Atp1a1 A G 3: 101,483,894 (GRCm39) V1017A probably benign Het
Cfap52 G T 11: 67,822,608 (GRCm39) T421K probably damaging Het
Chd8 A T 14: 52,459,970 (GRCm39) I780N probably damaging Het
Cubn T C 2: 13,299,181 (GRCm39) D3164G probably benign Het
Cyp4f37 A T 17: 32,844,142 (GRCm39) Q82L probably benign Het
Eml6 T A 11: 29,830,700 (GRCm39) D265V probably benign Het
Gm14393 T C 2: 174,903,595 (GRCm39) D104G possibly damaging Het
Gpat2 T C 2: 127,273,675 (GRCm39) V271A probably benign Het
Ifna4 T C 4: 88,760,423 (GRCm39) F109S probably damaging Het
Il27ra T C 8: 84,758,164 (GRCm39) S529G probably benign Het
Jag2 A G 12: 112,874,122 (GRCm39) L1011P probably benign Het
Kif7 A G 7: 79,356,507 (GRCm39) L728P probably damaging Het
Klhl21 T C 4: 152,099,817 (GRCm39) V509A probably benign Het
Map2k4 T A 11: 65,610,400 (GRCm39) N92I probably damaging Het
Myo15a A T 11: 60,374,308 (GRCm39) D1288V probably damaging Het
Or4k37 T C 2: 111,159,217 (GRCm39) V151A probably benign Het
Or5g25 C A 2: 85,478,096 (GRCm39) A190S possibly damaging Het
Paip1 T A 13: 119,582,348 (GRCm39) F275L possibly damaging Het
Plxnd1 T C 6: 115,936,937 (GRCm39) D1624G probably damaging Het
Ppwd1 C A 13: 104,346,261 (GRCm39) D465Y probably damaging Het
Resf1 T C 6: 149,228,538 (GRCm39) L528P probably damaging Het
Rftn1 A C 17: 50,476,180 (GRCm39) probably benign Het
Scn1b T A 7: 30,817,182 (GRCm39) Y180F probably damaging Het
Slc16a4 A G 3: 107,208,111 (GRCm39) D207G probably benign Het
Slc2a3 T C 6: 122,717,373 (GRCm39) T28A probably damaging Het
Slc47a1 G A 11: 61,253,643 (GRCm39) probably benign Het
Spata1 A T 3: 146,193,122 (GRCm39) V123D possibly damaging Het
Stard9 T C 2: 120,544,288 (GRCm39) V4469A probably damaging Het
Trmu T A 15: 85,781,033 (GRCm39) probably null Het
Trrap T A 5: 144,777,889 (GRCm39) probably benign Het
Ttn T C 2: 76,726,475 (GRCm39) probably benign Het
Tubgcp6 T C 15: 88,988,027 (GRCm39) D974G probably benign Het
Tyw1 C T 5: 130,364,171 (GRCm39) R621C probably benign Het
Usp7 A T 16: 8,513,058 (GRCm39) probably benign Het
Zfp692 C T 11: 58,199,765 (GRCm39) T118M probably damaging Het
Other mutations in Zfp39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00791:Zfp39 APN 11 58,783,885 (GRCm39) splice site probably benign
IGL01597:Zfp39 APN 11 58,782,369 (GRCm39) missense probably damaging 0.96
IGL02055:Zfp39 APN 11 58,782,156 (GRCm39) missense probably benign
IGL02456:Zfp39 APN 11 58,793,626 (GRCm39) nonsense probably null
H8562:Zfp39 UTSW 11 58,791,512 (GRCm39) missense probably damaging 1.00
R0462:Zfp39 UTSW 11 58,781,232 (GRCm39) missense probably benign 0.03
R0513:Zfp39 UTSW 11 58,780,813 (GRCm39) missense probably benign 0.09
R1185:Zfp39 UTSW 11 58,793,670 (GRCm39) missense possibly damaging 0.91
R1185:Zfp39 UTSW 11 58,793,670 (GRCm39) missense possibly damaging 0.91
R1185:Zfp39 UTSW 11 58,793,670 (GRCm39) missense possibly damaging 0.91
R1401:Zfp39 UTSW 11 58,781,149 (GRCm39) missense probably benign 0.01
R1797:Zfp39 UTSW 11 58,791,486 (GRCm39) missense probably damaging 0.96
R2146:Zfp39 UTSW 11 58,781,158 (GRCm39) missense probably benign 0.05
R3903:Zfp39 UTSW 11 58,781,001 (GRCm39) missense probably benign 0.44
R4303:Zfp39 UTSW 11 58,780,843 (GRCm39) missense probably damaging 1.00
R4706:Zfp39 UTSW 11 58,793,633 (GRCm39) missense probably benign 0.41
R4957:Zfp39 UTSW 11 58,782,057 (GRCm39) missense possibly damaging 0.63
R5092:Zfp39 UTSW 11 58,782,028 (GRCm39) missense possibly damaging 0.71
R5158:Zfp39 UTSW 11 58,780,671 (GRCm39) missense possibly damaging 0.81
R5292:Zfp39 UTSW 11 58,791,415 (GRCm39) missense probably damaging 0.97
R5697:Zfp39 UTSW 11 58,780,661 (GRCm39) missense probably benign 0.08
R5906:Zfp39 UTSW 11 58,793,717 (GRCm39) missense probably benign
R5925:Zfp39 UTSW 11 58,782,099 (GRCm39) missense possibly damaging 0.94
R6174:Zfp39 UTSW 11 58,782,213 (GRCm39) missense probably benign 0.01
R6177:Zfp39 UTSW 11 58,781,887 (GRCm39) missense probably benign 0.27
R6968:Zfp39 UTSW 11 58,782,306 (GRCm39) missense probably benign 0.00
R7045:Zfp39 UTSW 11 58,781,269 (GRCm39) missense unknown
R7139:Zfp39 UTSW 11 58,781,385 (GRCm39) missense probably damaging 1.00
R7421:Zfp39 UTSW 11 58,780,933 (GRCm39) missense probably damaging 1.00
R7493:Zfp39 UTSW 11 58,781,869 (GRCm39) missense possibly damaging 0.82
R7689:Zfp39 UTSW 11 58,781,469 (GRCm39) missense probably damaging 1.00
R8061:Zfp39 UTSW 11 58,793,573 (GRCm39) missense probably benign
R8136:Zfp39 UTSW 11 58,782,228 (GRCm39) missense probably damaging 0.99
R8955:Zfp39 UTSW 11 58,780,946 (GRCm39) nonsense probably null
Z1186:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1186:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1186:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1186:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1186:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1186:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1186:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1186:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1186:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1186:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1186:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1186:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1187:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1187:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1187:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1187:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1187:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1187:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1187:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1187:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1187:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1187:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1187:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1187:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,781,712 (GRCm39) missense probably benign 0.01
Z1187:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1188:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1188:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1188:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,781,712 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1188:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1188:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1188:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1188:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1188:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1188:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1188:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1188:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1188:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1188:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1189:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1189:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1189:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1189:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1189:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1189:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1189:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1189:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1189:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1189:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1189:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1189:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1189:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1189:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1190:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1190:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1190:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1190:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1190:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1190:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1190:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1190:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1190:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1190:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1190:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1190:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1190:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1191:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1191:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1191:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1191:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1191:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1191:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1191:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1191:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1191:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1191:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1191:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1191:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,781,712 (GRCm39) missense probably benign 0.01
Z1191:Zfp39 UTSW 11 58,781,702 (GRCm39) missense probably damaging 0.97
Z1192:Zfp39 UTSW 11 58,781,605 (GRCm39) missense probably benign 0.09
Z1192:Zfp39 UTSW 11 58,781,597 (GRCm39) missense probably benign 0.00
Z1192:Zfp39 UTSW 11 58,781,526 (GRCm39) missense possibly damaging 0.50
Z1192:Zfp39 UTSW 11 58,781,274 (GRCm39) missense possibly damaging 0.86
Z1192:Zfp39 UTSW 11 58,781,273 (GRCm39) missense probably benign 0.16
Z1192:Zfp39 UTSW 11 58,781,130 (GRCm39) missense possibly damaging 0.91
Z1192:Zfp39 UTSW 11 58,780,873 (GRCm39) missense probably benign 0.01
Z1192:Zfp39 UTSW 11 58,780,871 (GRCm39) nonsense probably null
Z1192:Zfp39 UTSW 11 58,791,409 (GRCm39) missense probably benign 0.01
Z1192:Zfp39 UTSW 11 58,791,407 (GRCm39) missense probably benign 0.01
Z1192:Zfp39 UTSW 11 58,782,142 (GRCm39) missense probably benign
Z1192:Zfp39 UTSW 11 58,782,123 (GRCm39) missense probably benign
Z1192:Zfp39 UTSW 11 58,781,967 (GRCm39) missense probably damaging 0.99
Z1192:Zfp39 UTSW 11 58,781,751 (GRCm39) missense probably benign 0.29
Z1192:Zfp39 UTSW 11 58,781,724 (GRCm39) missense probably benign 0.01
Posted On 2015-12-18