Incidental Mutation 'IGL02877:Olfr845'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr845
Ensembl Gene ENSMUSG00000061614
Gene Nameolfactory receptor 845
SynonymsOlfr1522-ps1, MOR150-2, MOR150-1P, GA_x6K02T2PVTD-13076685-13077623, MOR150-1P, MOR150-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.126) question?
Stock #IGL02877
Quality Score
Chromosomal Location19336457-19341718 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 19339201 bp
Amino Acid Change Valine to Alanine at position 247 (V247A)
Ref Sequence ENSEMBL: ENSMUSP00000150474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071259] [ENSMUST00000213344] [ENSMUST00000215572]
Predicted Effect possibly damaging
Transcript: ENSMUST00000071259
AA Change: V247A

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000071239
Gene: ENSMUSG00000061614
AA Change: V247A

Pfam:7tm_4 31 307 1.1e-56 PFAM
Pfam:7tm_1 41 290 2.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212246
AA Change: V247A
Predicted Effect possibly damaging
Transcript: ENSMUST00000213344
AA Change: V247A

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215572
AA Change: V247A

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass A T 6: 23,078,876 Y712* probably null Het
Adcy5 A G 16: 35,298,600 D1107G probably damaging Het
Ankhd1 C A 18: 36,594,823 T504K probably damaging Het
Asb18 C T 1: 89,952,811 C160Y possibly damaging Het
Capn13 A G 17: 73,322,055 S586P probably damaging Het
Cdhr2 A T 13: 54,734,737 T1199S probably benign Het
Ces1d C A 8: 93,169,718 probably null Het
Cnot8 A G 11: 58,111,402 E87G probably benign Het
Crnkl1 C A 2: 145,920,671 E525* probably null Het
Eif2d T C 1: 131,165,117 probably benign Het
Flywch1 A G 17: 23,760,414 S416P probably damaging Het
Glcci1 T C 6: 8,582,757 S373P probably damaging Het
Gli3 A G 13: 15,724,742 R905G probably damaging Het
Hcn4 T C 9: 58,859,167 V706A unknown Het
Ift74 T C 4: 94,624,781 probably null Het
Ighv8-6 A T 12: 115,166,080 S19T probably damaging Het
Knl1 T A 2: 119,088,831 N1821K probably benign Het
Msx1 G A 5: 37,824,000 P112S possibly damaging Het
Nes A G 3: 87,975,661 D409G probably benign Het
Nsmf A T 2: 25,055,956 I152F possibly damaging Het
Nt5c1a T A 4: 123,216,074 I322N probably damaging Het
Pnpla8 A G 12: 44,283,465 T49A probably benign Het
Ptx3 A G 3: 66,224,775 Y239C probably damaging Het
Rarg G T 15: 102,241,939 probably null Het
Slc33a1 G A 3: 63,943,385 T506I probably benign Het
Spem2 T G 11: 69,817,695 H148P probably benign Het
Trim24 A G 6: 37,965,646 D961G probably damaging Het
Vmn2r14 G A 5: 109,220,188 H313Y probably damaging Het
Other mutations in Olfr845
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01546:Olfr845 APN 9 19338772 missense possibly damaging 0.56
IGL01637:Olfr845 APN 9 19338964 missense probably damaging 1.00
IGL01767:Olfr845 APN 9 19339302 missense possibly damaging 0.54
IGL01945:Olfr845 APN 9 19339332 missense probably damaging 0.98
IGL02202:Olfr845 APN 9 19339249 missense probably benign 0.06
R0466:Olfr845 UTSW 9 19339179 missense probably damaging 1.00
R1521:Olfr845 UTSW 9 19338652 missense probably benign 0.35
R1650:Olfr845 UTSW 9 19338647 missense possibly damaging 0.49
R1766:Olfr845 UTSW 9 19338858 missense probably benign 0.06
R2060:Olfr845 UTSW 9 19339056 missense probably benign 0.01
R2082:Olfr845 UTSW 9 19339278 missense probably benign 0.36
R2257:Olfr845 UTSW 9 19338493 missense probably benign 0.01
R2892:Olfr845 UTSW 9 19338738 missense probably benign 0.04
R3156:Olfr845 UTSW 9 19339424 unclassified probably null
R3943:Olfr845 UTSW 9 19339075 missense probably benign 0.05
R4116:Olfr845 UTSW 9 19338644 missense probably benign 0.39
R4518:Olfr845 UTSW 9 19339260 missense possibly damaging 0.86
R4814:Olfr845 UTSW 9 19339180 missense probably damaging 1.00
R5339:Olfr845 UTSW 9 19339159 missense possibly damaging 0.78
R6647:Olfr845 UTSW 9 19338629 missense possibly damaging 0.50
R7493:Olfr845 UTSW 9 19338813 missense probably damaging 0.98
R7522:Olfr845 UTSW 9 19338998 nonsense probably null
R7584:Olfr845 UTSW 9 19339273 missense possibly damaging 0.94
Posted On2015-12-18