Incidental Mutation 'IGL02879:Vmn2r11'
ID362731
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r11
Ensembl Gene ENSMUSG00000091450
Gene Namevomeronasal 2, receptor 11
SynonymsEG384219
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.090) question?
Stock #IGL02879
Quality Score
Status
Chromosome5
Chromosomal Location109046873-109059452 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 109053838 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Asparagine at position 267 (Y267N)
Ref Sequence ENSEMBL: ENSMUSP00000133218 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164875]
Predicted Effect possibly damaging
Transcript: ENSMUST00000164875
AA Change: Y267N

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: Y267N

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 167 475 1.6e-29 PFAM
Pfam:NCD3G 520 574 9.1e-19 PFAM
Pfam:7tm_3 607 842 4.6e-55 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl3 A G 5: 81,512,119 Y245C probably damaging Het
Asb3 G A 11: 31,101,067 R507H probably damaging Het
AU019823 C T 9: 50,609,371 probably null Het
Cacna1g A C 11: 94,409,605 I2118S probably benign Het
Col3a1 A T 1: 45,340,959 probably benign Het
Ecscr T C 18: 35,713,678 N221S possibly damaging Het
Enpp4 T C 17: 44,101,950 D231G probably benign Het
Fastkd5 A G 2: 130,614,421 Y750H probably damaging Het
Gm42688 A G 6: 83,107,144 Y510C probably damaging Het
Gtse1 T C 15: 85,869,063 probably benign Het
Il4ra A G 7: 125,576,897 E759G possibly damaging Het
Itgb4 A G 11: 115,994,352 D1019G probably benign Het
Kcnh1 T C 1: 192,276,915 V259A probably damaging Het
Ksr1 G A 11: 79,074,444 L15F probably damaging Het
Lrrc40 G A 3: 158,041,665 probably benign Het
Myh15 A T 16: 49,173,059 T1686S possibly damaging Het
Neb A C 2: 52,256,685 L2856V possibly damaging Het
Pcnx2 A T 8: 125,772,057 C1568S probably damaging Het
Pld5 T A 1: 175,970,591 K352I probably damaging Het
Prmt3 A G 7: 49,818,063 D339G probably benign Het
Ptbp2 A G 3: 119,740,405 Y272H probably damaging Het
Ptprb A G 10: 116,327,968 D847G probably benign Het
Rin1 C T 19: 5,051,355 T89I probably damaging Het
Runx1t1 T C 4: 13,889,868 I599T unknown Het
Serinc3 A G 2: 163,632,252 probably benign Het
Slc27a5 C T 7: 12,995,044 probably benign Het
Terf2 C T 8: 107,076,697 S417N probably benign Het
Tyw1 T C 5: 130,296,771 V500A probably damaging Het
Upk1b G A 16: 38,776,278 probably benign Het
Vmn1r81 C T 7: 12,260,392 M96I probably benign Het
Other mutations in Vmn2r11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00925:Vmn2r11 APN 5 109047019 missense probably benign 0.00
IGL01677:Vmn2r11 APN 5 109053957 missense possibly damaging 0.50
IGL02048:Vmn2r11 APN 5 109054792 missense probably benign 0.00
IGL02559:Vmn2r11 APN 5 109052180 missense probably damaging 0.98
IGL03084:Vmn2r11 APN 5 109059343 missense probably benign 0.00
IGL03163:Vmn2r11 APN 5 109053826 missense probably benign 0.41
IGL03289:Vmn2r11 APN 5 109048922 splice site probably benign
IGL03294:Vmn2r11 APN 5 109054069 missense probably benign 0.22
R0233:Vmn2r11 UTSW 5 109054102 missense probably benign 0.16
R0233:Vmn2r11 UTSW 5 109054102 missense probably benign 0.16
R0421:Vmn2r11 UTSW 5 109059428 missense probably benign 0.00
R0549:Vmn2r11 UTSW 5 109052097 missense possibly damaging 0.80
R0628:Vmn2r11 UTSW 5 109047731 missense possibly damaging 0.88
R1523:Vmn2r11 UTSW 5 109053841 missense probably benign 0.25
R1660:Vmn2r11 UTSW 5 109053858 missense possibly damaging 0.79
R1827:Vmn2r11 UTSW 5 109052072 missense probably benign 0.01
R1913:Vmn2r11 UTSW 5 109054788 missense probably benign
R2260:Vmn2r11 UTSW 5 109053791 nonsense probably null
R2400:Vmn2r11 UTSW 5 109052062 missense probably benign 0.03
R3933:Vmn2r11 UTSW 5 109053394 missense probably damaging 0.97
R4091:Vmn2r11 UTSW 5 109054750 critical splice donor site probably null
R4624:Vmn2r11 UTSW 5 109052235 missense probably damaging 0.99
R4762:Vmn2r11 UTSW 5 109047570 missense probably damaging 1.00
R5256:Vmn2r11 UTSW 5 109054792 missense probably benign 0.26
R5370:Vmn2r11 UTSW 5 109047555 missense probably damaging 1.00
R5419:Vmn2r11 UTSW 5 109059358 missense possibly damaging 0.55
R5516:Vmn2r11 UTSW 5 109047166 missense probably damaging 0.98
R5643:Vmn2r11 UTSW 5 109047003 missense probably damaging 1.00
R5671:Vmn2r11 UTSW 5 109054906 missense probably benign 0.03
R5679:Vmn2r11 UTSW 5 109054842 missense probably benign 0.00
R5739:Vmn2r11 UTSW 5 109059248 critical splice donor site probably null
R5746:Vmn2r11 UTSW 5 109053694 missense probably benign 0.41
R5995:Vmn2r11 UTSW 5 109047055 missense probably damaging 1.00
R6147:Vmn2r11 UTSW 5 109054834 missense probably benign 0.04
R6220:Vmn2r11 UTSW 5 109053568 missense probably benign 0.09
R6374:Vmn2r11 UTSW 5 109053813 missense possibly damaging 0.65
R6491:Vmn2r11 UTSW 5 109048934 missense possibly damaging 0.95
R6804:Vmn2r11 UTSW 5 109053484 missense probably damaging 1.00
R6814:Vmn2r11 UTSW 5 109047110 missense possibly damaging 0.81
R6872:Vmn2r11 UTSW 5 109047110 missense possibly damaging 0.81
R7014:Vmn2r11 UTSW 5 109053423 missense probably damaging 1.00
R7041:Vmn2r11 UTSW 5 109054950 missense probably damaging 1.00
R7043:Vmn2r11 UTSW 5 109052232 missense probably benign 0.00
R7050:Vmn2r11 UTSW 5 109054791 missense probably benign 0.05
R7184:Vmn2r11 UTSW 5 109053415 missense probably damaging 1.00
R7388:Vmn2r11 UTSW 5 109054876 missense probably benign 0.05
R7477:Vmn2r11 UTSW 5 109059348 missense possibly damaging 0.67
R7524:Vmn2r11 UTSW 5 109053982 missense probably benign 0.01
R7682:Vmn2r11 UTSW 5 109047615 missense probably benign 0.02
R7715:Vmn2r11 UTSW 5 109047441 missense probably damaging 0.99
R7869:Vmn2r11 UTSW 5 109052120 missense probably damaging 1.00
R7952:Vmn2r11 UTSW 5 109052120 missense probably damaging 1.00
Posted On2015-12-18