Incidental Mutation 'IGL02879:Vmn1r81'
ID362737
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r81
Ensembl Gene ENSMUSG00000115027
Gene Namevomeronasal 1 receptor 81
SynonymsV1rg9
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.804) question?
Stock #IGL02879
Quality Score
Status
Chromosome7
Chromosomal Location12247241-12268269 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 12260392 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 96 (M96I)
Ref Sequence ENSEMBL: ENSMUSP00000153780 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086232] [ENSMUST00000227080] [ENSMUST00000227973] [ENSMUST00000228482] [ENSMUST00000228764]
Predicted Effect probably benign
Transcript: ENSMUST00000086232
AA Change: M96I

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000083409
Gene: ENSMUSG00000115027
AA Change: M96I

DomainStartEndE-ValueType
Pfam:TAS2R 3 301 5.4e-12 PFAM
Pfam:V1R 34 299 6.6e-31 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227080
AA Change: M96I

PolyPhen 2 Score 0.198 (Sensitivity: 0.92; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000227973
AA Change: M96I

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228482
AA Change: M96I

PolyPhen 2 Score 0.198 (Sensitivity: 0.92; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000228764
AA Change: M96I

PolyPhen 2 Score 0.166 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl3 A G 5: 81,512,119 Y245C probably damaging Het
Asb3 G A 11: 31,101,067 R507H probably damaging Het
AU019823 C T 9: 50,609,371 probably null Het
Cacna1g A C 11: 94,409,605 I2118S probably benign Het
Col3a1 A T 1: 45,340,959 probably benign Het
Ecscr T C 18: 35,713,678 N221S possibly damaging Het
Enpp4 T C 17: 44,101,950 D231G probably benign Het
Fastkd5 A G 2: 130,614,421 Y750H probably damaging Het
Gm42688 A G 6: 83,107,144 Y510C probably damaging Het
Gtse1 T C 15: 85,869,063 probably benign Het
Il4ra A G 7: 125,576,897 E759G possibly damaging Het
Itgb4 A G 11: 115,994,352 D1019G probably benign Het
Kcnh1 T C 1: 192,276,915 V259A probably damaging Het
Ksr1 G A 11: 79,074,444 L15F probably damaging Het
Lrrc40 G A 3: 158,041,665 probably benign Het
Myh15 A T 16: 49,173,059 T1686S possibly damaging Het
Neb A C 2: 52,256,685 L2856V possibly damaging Het
Pcnx2 A T 8: 125,772,057 C1568S probably damaging Het
Pld5 T A 1: 175,970,591 K352I probably damaging Het
Prmt3 A G 7: 49,818,063 D339G probably benign Het
Ptbp2 A G 3: 119,740,405 Y272H probably damaging Het
Ptprb A G 10: 116,327,968 D847G probably benign Het
Rin1 C T 19: 5,051,355 T89I probably damaging Het
Runx1t1 T C 4: 13,889,868 I599T unknown Het
Serinc3 A G 2: 163,632,252 probably benign Het
Slc27a5 C T 7: 12,995,044 probably benign Het
Terf2 C T 8: 107,076,697 S417N probably benign Het
Tyw1 T C 5: 130,296,771 V500A probably damaging Het
Upk1b G A 16: 38,776,278 probably benign Het
Vmn2r11 A T 5: 109,053,838 Y267N possibly damaging Het
Other mutations in Vmn1r81
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02026:Vmn1r81 APN 7 12260505 missense probably damaging 1.00
IGL02086:Vmn1r81 APN 7 12259865 missense possibly damaging 0.82
IGL02751:Vmn1r81 APN 7 12260447 missense probably damaging 1.00
IGL03358:Vmn1r81 APN 7 12260305 missense possibly damaging 0.57
PIT4305001:Vmn1r81 UTSW 7 12260663 missense probably benign 0.01
R0359:Vmn1r81 UTSW 7 12259950 missense probably damaging 1.00
R1615:Vmn1r81 UTSW 7 12260514 missense probably damaging 1.00
R1938:Vmn1r81 UTSW 7 12260662 missense possibly damaging 0.67
R2967:Vmn1r81 UTSW 7 12260037 missense probably damaging 0.99
R2983:Vmn1r81 UTSW 7 12260669 missense probably benign 0.02
R4549:Vmn1r81 UTSW 7 12259822 missense probably damaging 0.99
R5099:Vmn1r81 UTSW 7 12260321 missense possibly damaging 0.86
R5326:Vmn1r81 UTSW 7 12260107 missense probably damaging 1.00
R5542:Vmn1r81 UTSW 7 12260107 missense probably damaging 1.00
R6010:Vmn1r81 UTSW 7 12260422 missense possibly damaging 0.88
R6630:Vmn1r81 UTSW 7 12260657 nonsense probably null
R6724:Vmn1r81 UTSW 7 12260672 missense probably damaging 1.00
R6754:Vmn1r81 UTSW 7 12259847 missense probably damaging 0.98
R8198:Vmn1r81 UTSW 7 12259955 missense possibly damaging 0.64
Posted On2015-12-18