Incidental Mutation 'IGL02879:Gtse1'
ID362758
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gtse1
Ensembl Gene ENSMUSG00000022385
Gene NameG two S phase expressed protein 1
SynonymsB99, Gtse-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.082) question?
Stock #IGL02879
Quality Score
Status
Chromosome15
Chromosomal Location85859745-85876573 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 85869063 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155552 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170629] [ENSMUST00000231074]
Predicted Effect probably benign
Transcript: ENSMUST00000170629
SMART Domains Protein: ENSMUSP00000128759
Gene: ENSMUSG00000022385

DomainStartEndE-ValueType
Pfam:GTSE1_N 10 153 3e-62 PFAM
low complexity region 284 301 N/A INTRINSIC
low complexity region 310 321 N/A INTRINSIC
low complexity region 360 372 N/A INTRINSIC
low complexity region 478 497 N/A INTRINSIC
low complexity region 568 593 N/A INTRINSIC
low complexity region 644 653 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000231074
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl3 A G 5: 81,512,119 Y245C probably damaging Het
Asb3 G A 11: 31,101,067 R507H probably damaging Het
AU019823 C T 9: 50,609,371 probably null Het
Cacna1g A C 11: 94,409,605 I2118S probably benign Het
Col3a1 A T 1: 45,340,959 probably benign Het
Ecscr T C 18: 35,713,678 N221S possibly damaging Het
Enpp4 T C 17: 44,101,950 D231G probably benign Het
Fastkd5 A G 2: 130,614,421 Y750H probably damaging Het
Gm42688 A G 6: 83,107,144 Y510C probably damaging Het
Il4ra A G 7: 125,576,897 E759G possibly damaging Het
Itgb4 A G 11: 115,994,352 D1019G probably benign Het
Kcnh1 T C 1: 192,276,915 V259A probably damaging Het
Ksr1 G A 11: 79,074,444 L15F probably damaging Het
Lrrc40 G A 3: 158,041,665 probably benign Het
Myh15 A T 16: 49,173,059 T1686S possibly damaging Het
Neb A C 2: 52,256,685 L2856V possibly damaging Het
Pcnx2 A T 8: 125,772,057 C1568S probably damaging Het
Pld5 T A 1: 175,970,591 K352I probably damaging Het
Prmt3 A G 7: 49,818,063 D339G probably benign Het
Ptbp2 A G 3: 119,740,405 Y272H probably damaging Het
Ptprb A G 10: 116,327,968 D847G probably benign Het
Rin1 C T 19: 5,051,355 T89I probably damaging Het
Runx1t1 T C 4: 13,889,868 I599T unknown Het
Serinc3 A G 2: 163,632,252 probably benign Het
Slc27a5 C T 7: 12,995,044 probably benign Het
Terf2 C T 8: 107,076,697 S417N probably benign Het
Tyw1 T C 5: 130,296,771 V500A probably damaging Het
Upk1b G A 16: 38,776,278 probably benign Het
Vmn1r81 C T 7: 12,260,392 M96I probably benign Het
Vmn2r11 A T 5: 109,053,838 Y267N possibly damaging Het
Other mutations in Gtse1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Gtse1 APN 15 85868817 missense possibly damaging 0.54
IGL01344:Gtse1 APN 15 85862066 critical splice acceptor site probably null
IGL01541:Gtse1 APN 15 85875654 nonsense probably null
IGL01621:Gtse1 APN 15 85875082 missense probably benign 0.01
IGL01945:Gtse1 APN 15 85871547 missense probably benign 0.00
IGL02193:Gtse1 APN 15 85862330 missense probably benign 0.27
IGL02215:Gtse1 APN 15 85862598 missense possibly damaging 0.92
IGL02494:Gtse1 APN 15 85867503 missense probably damaging 1.00
R0009:Gtse1 UTSW 15 85862435 missense probably benign 0.06
R0047:Gtse1 UTSW 15 85862378 missense probably damaging 1.00
R0047:Gtse1 UTSW 15 85862378 missense probably damaging 1.00
R0576:Gtse1 UTSW 15 85869051 missense probably damaging 1.00
R1078:Gtse1 UTSW 15 85862307 missense probably damaging 0.98
R1442:Gtse1 UTSW 15 85860102 splice site probably benign
R1623:Gtse1 UTSW 15 85867578 missense probably benign
R1925:Gtse1 UTSW 15 85873738 missense probably benign 0.00
R1928:Gtse1 UTSW 15 85862063 splice site probably benign
R4565:Gtse1 UTSW 15 85875184 missense probably damaging 0.99
R5170:Gtse1 UTSW 15 85864264 critical splice donor site probably null
R5310:Gtse1 UTSW 15 85873792 missense probably benign 0.04
R5428:Gtse1 UTSW 15 85862139 missense probably benign 0.12
R5748:Gtse1 UTSW 15 85867577 missense probably benign
R5996:Gtse1 UTSW 15 85864180 missense probably benign 0.00
R6179:Gtse1 UTSW 15 85868957 missense possibly damaging 0.95
R6379:Gtse1 UTSW 15 85864224 missense probably benign 0.01
R6381:Gtse1 UTSW 15 85862148 missense probably benign 0.00
R6434:Gtse1 UTSW 15 85875169 missense probably benign 0.21
R7086:Gtse1 UTSW 15 85875549 missense probably damaging 1.00
R7304:Gtse1 UTSW 15 85871547 missense probably benign 0.00
R7485:Gtse1 UTSW 15 85868700 missense probably benign 0.04
R7580:Gtse1 UTSW 15 85862231 missense probably damaging 1.00
Posted On2015-12-18