Incidental Mutation 'IGL02882:Foxn2'
ID362835
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Foxn2
Ensembl Gene ENSMUSG00000034998
Gene Nameforkhead box N2
Synonyms6030465J18Rik, 3230402J05Rik, Fkh19, HTLF
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.236) question?
Stock #IGL02882
Quality Score
Status
Chromosome17
Chromosomal Location88440711-88490533 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 88462947 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 74 (L74P)
Ref Sequence ENSEMBL: ENSMUSP00000116123 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112238] [ENSMUST00000141052] [ENSMUST00000155640]
Predicted Effect probably damaging
Transcript: ENSMUST00000112238
AA Change: L74P

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000107857
Gene: ENSMUSG00000034998
AA Change: L74P

DomainStartEndE-ValueType
FH 110 202 7.42e-50 SMART
low complexity region 314 323 N/A INTRINSIC
low complexity region 348 358 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134107
Predicted Effect probably damaging
Transcript: ENSMUST00000141052
AA Change: L74P

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000118378
Gene: ENSMUSG00000034998
AA Change: L74P

DomainStartEndE-ValueType
FH 110 203 2.15e-37 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000155640
AA Change: L74P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 A T 9: 44,277,489 L469* probably null Het
Calr3 T A 8: 72,434,821 Y46F probably damaging Het
Clcn4 A G 7: 7,290,465 C491R probably damaging Het
Col6a5 G T 9: 105,934,321 D666E unknown Het
D130052B06Rik G A 11: 33,623,780 V126M probably damaging Het
Ddx27 A G 2: 167,027,913 I389M possibly damaging Het
Dgka T C 10: 128,733,384 I160V possibly damaging Het
E430018J23Rik A G 7: 127,392,252 Y188H probably damaging Het
Enpp6 T C 8: 47,030,532 S120P probably damaging Het
Ezh1 A G 11: 101,203,289 I459T probably benign Het
Fam91a1 A G 15: 58,453,061 probably benign Het
Fscn2 T C 11: 120,362,499 V264A probably benign Het
Gmeb2 G A 2: 181,265,883 T54I probably damaging Het
Hmcn2 A T 2: 31,413,367 K3007* probably null Het
Ice1 A T 13: 70,624,474 probably benign Het
Lgi1 A G 19: 38,284,005 D84G probably benign Het
Mier2 T C 10: 79,547,721 I196V probably damaging Het
Nipal2 T C 15: 34,600,077 Y198C probably damaging Het
Npas2 A C 1: 39,312,996 S176R probably benign Het
Olfr914 A T 9: 38,606,938 I158F probably benign Het
Pam A C 1: 97,840,367 C713G probably damaging Het
Pcdh17 C A 14: 84,446,661 D189E probably damaging Het
Pcdhb8 T A 18: 37,356,223 I318N possibly damaging Het
Pcyt2 A G 11: 120,611,407 S300P possibly damaging Het
Pkdrej A G 15: 85,817,296 S1480P probably damaging Het
Plekhd1 G A 12: 80,719,007 probably null Het
Plxna2 A T 1: 194,762,570 S757C probably damaging Het
Prkdc A T 16: 15,651,519 K163* probably null Het
Serpina3f A T 12: 104,217,004 T42S probably damaging Het
Sesn2 T C 4: 132,493,793 N456D probably benign Het
Tas2r105 A T 6: 131,687,180 L95Q possibly damaging Het
Tln1 A G 4: 43,539,522 V1600A probably benign Het
Zfp808 A G 13: 62,173,180 K741R probably benign Het
Other mutations in Foxn2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00685:Foxn2 APN 17 88462877 missense probably benign 0.02
IGL00952:Foxn2 APN 17 88475880 missense probably benign 0.03
IGL02232:Foxn2 APN 17 88463051 missense probably benign 0.03
IGL02974:Foxn2 APN 17 88463115 missense probably damaging 1.00
R1170:Foxn2 UTSW 17 88473666 critical splice acceptor site probably benign
R1826:Foxn2 UTSW 17 88486805 missense possibly damaging 0.87
R3825:Foxn2 UTSW 17 88484409 missense probably damaging 0.98
R4761:Foxn2 UTSW 17 88462708 splice site probably null
R5914:Foxn2 UTSW 17 88462710 splice site probably null
R6735:Foxn2 UTSW 17 88486795 missense probably benign
R7461:Foxn2 UTSW 17 88486883 missense possibly damaging 0.93
R7613:Foxn2 UTSW 17 88486883 missense possibly damaging 0.93
X0026:Foxn2 UTSW 17 88486733 missense probably benign 0.00
Posted On2015-12-18