Incidental Mutation 'IGL02882:Foxn2'
| ID |
362835 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Foxn2
|
| Ensembl Gene |
ENSMUSG00000034998 |
| Gene Name |
forkhead box N2 |
| Synonyms |
Fkh19, 6030465J18Rik, HTLF, 3230402J05Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.258)
|
| Stock # |
IGL02882
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
88748139-88797961 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 88770375 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 74
(L74P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116123
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112238]
[ENSMUST00000141052]
[ENSMUST00000155640]
|
| AlphaFold |
E9Q7L6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112238
AA Change: L74P
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000107857
Gene: ENSMUSG00000034998
AA Change: L74P
| Domain | Start | End | E-Value | Type |
|---|
|
FH
|
110 |
202 |
7.42e-50 |
SMART |
|
low complexity region
|
314 |
323 |
N/A |
INTRINSIC |
|
low complexity region
|
348 |
358 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134107
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000141052
AA Change: L74P
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000118378
Gene: ENSMUSG00000034998
AA Change: L74P
| Domain | Start | End | E-Value | Type |
|---|
|
FH
|
110 |
203 |
2.15e-37 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000155640
AA Change: L74P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg4 |
A |
T |
9: 44,188,786 (GRCm39) |
L469* |
probably null |
Het |
| Calr3 |
T |
A |
8: 73,188,665 (GRCm39) |
Y46F |
probably damaging |
Het |
| Clcn4 |
A |
G |
7: 7,293,464 (GRCm39) |
C491R |
probably damaging |
Het |
| Col6a5 |
G |
T |
9: 105,811,520 (GRCm39) |
D666E |
unknown |
Het |
| D130052B06Rik |
G |
A |
11: 33,573,780 (GRCm39) |
V126M |
probably damaging |
Het |
| Ddx27 |
A |
G |
2: 166,869,833 (GRCm39) |
I389M |
possibly damaging |
Het |
| Dgka |
T |
C |
10: 128,569,253 (GRCm39) |
I160V |
possibly damaging |
Het |
| Enpp6 |
T |
C |
8: 47,483,567 (GRCm39) |
S120P |
probably damaging |
Het |
| Ezh1 |
A |
G |
11: 101,094,115 (GRCm39) |
I459T |
probably benign |
Het |
| Fam91a1 |
A |
G |
15: 58,324,910 (GRCm39) |
|
probably benign |
Het |
| Fscn2 |
T |
C |
11: 120,253,325 (GRCm39) |
V264A |
probably benign |
Het |
| Gmeb2 |
G |
A |
2: 180,907,676 (GRCm39) |
T54I |
probably damaging |
Het |
| Hmcn2 |
A |
T |
2: 31,303,379 (GRCm39) |
K3007* |
probably null |
Het |
| Ice1 |
A |
T |
13: 70,772,593 (GRCm39) |
|
probably benign |
Het |
| Lgi1 |
A |
G |
19: 38,272,453 (GRCm39) |
D84G |
probably benign |
Het |
| Mier2 |
T |
C |
10: 79,383,555 (GRCm39) |
I196V |
probably damaging |
Het |
| Nipal2 |
T |
C |
15: 34,600,223 (GRCm39) |
Y198C |
probably damaging |
Het |
| Npas2 |
A |
C |
1: 39,352,077 (GRCm39) |
S176R |
probably benign |
Het |
| Or8b50 |
A |
T |
9: 38,518,234 (GRCm39) |
I158F |
probably benign |
Het |
| Pam |
A |
C |
1: 97,768,092 (GRCm39) |
C713G |
probably damaging |
Het |
| Pcdh17 |
C |
A |
14: 84,684,101 (GRCm39) |
D189E |
probably damaging |
Het |
| Pcdhb8 |
T |
A |
18: 37,489,276 (GRCm39) |
I318N |
possibly damaging |
Het |
| Pcyt2 |
A |
G |
11: 120,502,233 (GRCm39) |
S300P |
possibly damaging |
Het |
| Pkdrej |
A |
G |
15: 85,701,497 (GRCm39) |
S1480P |
probably damaging |
Het |
| Plekhd1 |
G |
A |
12: 80,765,781 (GRCm39) |
|
probably null |
Het |
| Plxna2 |
A |
T |
1: 194,444,878 (GRCm39) |
S757C |
probably damaging |
Het |
| Prkdc |
A |
T |
16: 15,469,383 (GRCm39) |
K163* |
probably null |
Het |
| Serpina3f |
A |
T |
12: 104,183,263 (GRCm39) |
T42S |
probably damaging |
Het |
| Sesn2 |
T |
C |
4: 132,221,104 (GRCm39) |
N456D |
probably benign |
Het |
| Tas2r105 |
A |
T |
6: 131,664,143 (GRCm39) |
L95Q |
possibly damaging |
Het |
| Tln1 |
A |
G |
4: 43,539,522 (GRCm39) |
V1600A |
probably benign |
Het |
| Zfp764l1 |
A |
G |
7: 126,991,424 (GRCm39) |
Y188H |
probably damaging |
Het |
| Zfp808 |
A |
G |
13: 62,320,994 (GRCm39) |
K741R |
probably benign |
Het |
|
| Other mutations in Foxn2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00685:Foxn2
|
APN |
17 |
88,770,305 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00952:Foxn2
|
APN |
17 |
88,783,308 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02232:Foxn2
|
APN |
17 |
88,770,479 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02974:Foxn2
|
APN |
17 |
88,770,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1170:Foxn2
|
UTSW |
17 |
88,781,094 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R1826:Foxn2
|
UTSW |
17 |
88,794,233 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3825:Foxn2
|
UTSW |
17 |
88,791,837 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4761:Foxn2
|
UTSW |
17 |
88,770,136 (GRCm39) |
splice site |
probably null |
|
|
R5914:Foxn2
|
UTSW |
17 |
88,770,138 (GRCm39) |
splice site |
probably null |
|
|
R6735:Foxn2
|
UTSW |
17 |
88,794,223 (GRCm39) |
missense |
probably benign |
|
|
R7461:Foxn2
|
UTSW |
17 |
88,794,311 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7613:Foxn2
|
UTSW |
17 |
88,794,311 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
X0026:Foxn2
|
UTSW |
17 |
88,794,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-12-18 |
Incidental Mutation