Incidental Mutation 'IGL02882:Tas2r105'
| ID |
362846 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r105
|
| Ensembl Gene |
ENSMUSG00000051153 |
| Gene Name |
taste receptor, type 2, member 105 |
| Synonyms |
T2r5, T2R05, mGR05, T2R9, mt2r5, Tas2r5 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.049)
|
| Stock # |
IGL02882
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
131663524-131664426 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 131664143 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 95
(L95Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000058006
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053652]
[ENSMUST00000072404]
[ENSMUST00000080619]
|
| AlphaFold |
Q9JKT4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000053652
AA Change: L95Q
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153
AA Change: L95Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
9.4e-109 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072404
|
| SMART Domains |
Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
8.3e-102 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080619
|
| SMART Domains |
Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
8.1e-104 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null mutation respond normally to a variety of bitter, sweet, umami, salty and sour stimuli but show a striking and selective impairement in their ability to taste cycloheximide (a bitter tastant). In addition, homozygotes are no longer behaviorally averse to cycloheximide. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg4 |
A |
T |
9: 44,188,786 (GRCm39) |
L469* |
probably null |
Het |
| Calr3 |
T |
A |
8: 73,188,665 (GRCm39) |
Y46F |
probably damaging |
Het |
| Clcn4 |
A |
G |
7: 7,293,464 (GRCm39) |
C491R |
probably damaging |
Het |
| Col6a5 |
G |
T |
9: 105,811,520 (GRCm39) |
D666E |
unknown |
Het |
| D130052B06Rik |
G |
A |
11: 33,573,780 (GRCm39) |
V126M |
probably damaging |
Het |
| Ddx27 |
A |
G |
2: 166,869,833 (GRCm39) |
I389M |
possibly damaging |
Het |
| Dgka |
T |
C |
10: 128,569,253 (GRCm39) |
I160V |
possibly damaging |
Het |
| Enpp6 |
T |
C |
8: 47,483,567 (GRCm39) |
S120P |
probably damaging |
Het |
| Ezh1 |
A |
G |
11: 101,094,115 (GRCm39) |
I459T |
probably benign |
Het |
| Fam91a1 |
A |
G |
15: 58,324,910 (GRCm39) |
|
probably benign |
Het |
| Foxn2 |
T |
C |
17: 88,770,375 (GRCm39) |
L74P |
probably damaging |
Het |
| Fscn2 |
T |
C |
11: 120,253,325 (GRCm39) |
V264A |
probably benign |
Het |
| Gmeb2 |
G |
A |
2: 180,907,676 (GRCm39) |
T54I |
probably damaging |
Het |
| Hmcn2 |
A |
T |
2: 31,303,379 (GRCm39) |
K3007* |
probably null |
Het |
| Ice1 |
A |
T |
13: 70,772,593 (GRCm39) |
|
probably benign |
Het |
| Lgi1 |
A |
G |
19: 38,272,453 (GRCm39) |
D84G |
probably benign |
Het |
| Mier2 |
T |
C |
10: 79,383,555 (GRCm39) |
I196V |
probably damaging |
Het |
| Nipal2 |
T |
C |
15: 34,600,223 (GRCm39) |
Y198C |
probably damaging |
Het |
| Npas2 |
A |
C |
1: 39,352,077 (GRCm39) |
S176R |
probably benign |
Het |
| Or8b50 |
A |
T |
9: 38,518,234 (GRCm39) |
I158F |
probably benign |
Het |
| Pam |
A |
C |
1: 97,768,092 (GRCm39) |
C713G |
probably damaging |
Het |
| Pcdh17 |
C |
A |
14: 84,684,101 (GRCm39) |
D189E |
probably damaging |
Het |
| Pcdhb8 |
T |
A |
18: 37,489,276 (GRCm39) |
I318N |
possibly damaging |
Het |
| Pcyt2 |
A |
G |
11: 120,502,233 (GRCm39) |
S300P |
possibly damaging |
Het |
| Pkdrej |
A |
G |
15: 85,701,497 (GRCm39) |
S1480P |
probably damaging |
Het |
| Plekhd1 |
G |
A |
12: 80,765,781 (GRCm39) |
|
probably null |
Het |
| Plxna2 |
A |
T |
1: 194,444,878 (GRCm39) |
S757C |
probably damaging |
Het |
| Prkdc |
A |
T |
16: 15,469,383 (GRCm39) |
K163* |
probably null |
Het |
| Serpina3f |
A |
T |
12: 104,183,263 (GRCm39) |
T42S |
probably damaging |
Het |
| Sesn2 |
T |
C |
4: 132,221,104 (GRCm39) |
N456D |
probably benign |
Het |
| Tln1 |
A |
G |
4: 43,539,522 (GRCm39) |
V1600A |
probably benign |
Het |
| Zfp764l1 |
A |
G |
7: 126,991,424 (GRCm39) |
Y188H |
probably damaging |
Het |
| Zfp808 |
A |
G |
13: 62,320,994 (GRCm39) |
K741R |
probably benign |
Het |
|
| Other mutations in Tas2r105 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01107:Tas2r105
|
APN |
6 |
131,664,074 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01148:Tas2r105
|
APN |
6 |
131,663,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0833:Tas2r105
|
UTSW |
6 |
131,664,393 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0836:Tas2r105
|
UTSW |
6 |
131,664,393 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1429:Tas2r105
|
UTSW |
6 |
131,663,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2010:Tas2r105
|
UTSW |
6 |
131,664,365 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2418:Tas2r105
|
UTSW |
6 |
131,664,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4023:Tas2r105
|
UTSW |
6 |
131,663,789 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4026:Tas2r105
|
UTSW |
6 |
131,663,789 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4742:Tas2r105
|
UTSW |
6 |
131,663,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5497:Tas2r105
|
UTSW |
6 |
131,663,805 (GRCm39) |
splice site |
probably null |
|
|
R5812:Tas2r105
|
UTSW |
6 |
131,663,836 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7191:Tas2r105
|
UTSW |
6 |
131,663,945 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7236:Tas2r105
|
UTSW |
6 |
131,663,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7482:Tas2r105
|
UTSW |
6 |
131,663,972 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8783:Tas2r105
|
UTSW |
6 |
131,663,732 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8986:Tas2r105
|
UTSW |
6 |
131,663,913 (GRCm39) |
nonsense |
probably null |
|
|
R9250:Tas2r105
|
UTSW |
6 |
131,663,951 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9580:Tas2r105
|
UTSW |
6 |
131,663,699 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0067:Tas2r105
|
UTSW |
6 |
131,664,233 (GRCm39) |
missense |
probably benign |
0.29 |
|
| Posted On |
2015-12-18 |
Incidental Mutation