Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02883:Mkrn2os'

362884

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mkrn2os

Ensembl Gene

ENSMUSG00000068011

Gene Name

makorin, ring finger protein 2, opposite strand

Synonyms

2510049J12Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL02883

Quality Score

Status

Chromosome

Chromosomal Location

115560508-115569537 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 115563670 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Stop codon at position 122 (G122*)

Ref Sequence

ENSEMBL: ENSMUSP00000108580 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088962] [ENSMUST00000112957]

AlphaFold

D3Z393

Predicted Effect

probably benign
Transcript: ENSMUST00000088962

Predicted Effect

probably null
Transcript: ENSMUST00000112957
AA Change: G122*

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810055G02Rik	C	A	19: 3,766,972 (GRCm39)	S186R	possibly damaging	Het
Acap2	A	G	16: 30,915,163 (GRCm39)		probably benign	Het
Cacna1h	G	T	17: 25,599,506 (GRCm39)	R1726S	probably damaging	Het
Cdca2	T	C	14: 67,944,946 (GRCm39)	S133G	probably damaging	Het
Cep295nl	A	T	11: 118,224,735 (GRCm39)	S36R	probably benign	Het
Crispld1	A	G	1: 17,817,013 (GRCm39)	N190S	possibly damaging	Het
Crtam	A	G	9: 40,905,797 (GRCm39)	V44A	probably benign	Het
Crtc1	C	T	8: 70,858,775 (GRCm39)	G112S	probably benign	Het
Cyp17a1	T	C	19: 46,657,790 (GRCm39)	N254S	probably benign	Het
Dmrta1	T	C	4: 89,577,011 (GRCm39)	S156P	probably benign	Het
Eno2	A	C	6: 124,743,172 (GRCm39)	V188G	probably damaging	Het
Fam20a	A	T	11: 109,565,953 (GRCm39)	I427N	probably damaging	Het
Fat2	T	C	11: 55,147,444 (GRCm39)	K3933E	probably benign	Het
Igkv8-30	T	C	6: 70,094,601 (GRCm39)	M1V	probably null	Het
Ist1	G	A	8: 110,410,300 (GRCm39)		probably benign	Het
Kank4	T	C	4: 98,661,690 (GRCm39)	E765G	possibly damaging	Het
Kat14	T	C	2: 144,235,449 (GRCm39)	L92S	probably damaging	Het
Kcnu1	G	A	8: 26,339,855 (GRCm39)	V58I	probably benign	Het
Lrba	T	A	3: 86,261,513 (GRCm39)	V1489E	probably damaging	Het
Lrba	T	A	3: 86,352,720 (GRCm39)	I1956N	probably damaging	Het
Mdn1	G	A	4: 32,763,199 (GRCm39)	V5100I	probably benign	Het
Nme3	T	C	17: 25,115,880 (GRCm39)	Y78H	probably benign	Het
Pira13	A	G	7: 3,825,179 (GRCm39)	S488P	possibly damaging	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Ppp2r5c	T	G	12: 110,488,997 (GRCm39)	V56G	possibly damaging	Het
Pramel16	T	C	4: 143,676,418 (GRCm39)	T229A	possibly damaging	Het
Prdm10	G	A	9: 31,238,644 (GRCm39)	V179M	probably damaging	Het
Rab11fip2	A	G	19: 59,895,430 (GRCm39)	V344A	probably damaging	Het
Selp	G	A	1: 163,957,671 (GRCm39)	A267T	probably benign	Het
Sf3a1	T	A	11: 4,129,192 (GRCm39)	W718R	probably damaging	Het
Taar9	T	C	10: 23,985,378 (GRCm39)	N19D	probably benign	Het
Tas2r113	T	G	6: 132,870,382 (GRCm39)	S137A	probably damaging	Het
Traf4	A	T	11: 78,052,447 (GRCm39)	I66N	possibly damaging	Het
Ucp3	A	T	7: 100,129,849 (GRCm39)	T164S	probably benign	Het
Uggt1	A	T	1: 36,216,696 (GRCm39)	N96K	probably benign	Het
Uqcc1	T	A	2: 155,753,749 (GRCm39)	Q42L	possibly damaging	Het
Vmn1r128	A	G	7: 21,083,440 (GRCm39)	K48R	probably benign	Het

Other mutations in Mkrn2os

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01759:Mkrn2os	APN	6	115,569,292 (GRCm39)	missense	probably benign	0.37
IGL01982:Mkrn2os	APN	6	115,562,492 (GRCm39)	missense	probably damaging	1.00
PIT4486001:Mkrn2os	UTSW	6	115,562,444 (GRCm39)	missense	probably benign	0.01
R0458:Mkrn2os	UTSW	6	115,563,631 (GRCm39)	missense	probably damaging	0.99
R1989:Mkrn2os	UTSW	6	115,566,311 (GRCm39)	missense	probably damaging	0.99
R7058:Mkrn2os	UTSW	6	115,563,635 (GRCm39)	missense	probably benign	0.01
R7167:Mkrn2os	UTSW	6	115,562,474 (GRCm39)	missense	probably damaging	0.99
R7609:Mkrn2os	UTSW	6	115,563,687 (GRCm39)	missense	possibly damaging	0.86
R8958:Mkrn2os	UTSW	6	115,562,317 (GRCm39)	missense	probably benign	0.18
R8959:Mkrn2os	UTSW	6	115,562,317 (GRCm39)	missense	probably benign	0.18
R9051:Mkrn2os	UTSW	6	115,562,325 (GRCm39)	missense	probably benign	0.23

Posted On

2015-12-18