Incidental Mutation 'IGL02885:Ces2b'
ID 362953
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ces2b
Ensembl Gene ENSMUSG00000050097
Gene Name carboxyesterase 2B
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # IGL02885
Quality Score
Status
Chromosome 8
Chromosomal Location 105558204-105566725 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 105561563 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 219 (V219A)
Ref Sequence ENSEMBL: ENSMUSP00000063005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059449] [ENSMUST00000163042]
AlphaFold Q6PDB7
Predicted Effect probably damaging
Transcript: ENSMUST00000059449
AA Change: V219A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000063005
Gene: ENSMUSG00000050097
AA Change: V219A

DomainStartEndE-ValueType
Pfam:COesterase 10 535 8.5e-175 PFAM
Pfam:Abhydrolase_3 140 305 1.8e-11 PFAM
Pfam:Peptidase_S9 161 296 9e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163042
SMART Domains Protein: ENSMUSP00000124796
Gene: ENSMUSG00000050097

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 81,948,152 (GRCm39) N683S probably benign Het
Ahi1 T A 10: 20,931,012 (GRCm39) F46I possibly damaging Het
Als2 C T 1: 59,206,650 (GRCm39) V1598I probably benign Het
Arid1b A T 17: 5,392,428 (GRCm39) D1986V probably damaging Het
Bhlhe41 T A 6: 145,810,989 (GRCm39) D2V probably damaging Het
Borcs6 A G 11: 68,951,072 (GRCm39) D150G possibly damaging Het
Ccdc88a G T 11: 29,398,050 (GRCm39) R261L probably damaging Het
Ccne2 T A 4: 11,198,723 (GRCm39) probably benign Het
Cenpk A G 13: 104,385,903 (GRCm39) D266G probably damaging Het
Cpa1 A G 6: 30,645,169 (GRCm39) R382G probably damaging Het
Cplx4 G T 18: 66,089,984 (GRCm39) T145N probably damaging Het
Cyp19a1 T C 9: 54,079,102 (GRCm39) I269V probably benign Het
Dennd3 A G 15: 73,440,545 (GRCm39) Y1192C probably benign Het
Dpp6 T C 5: 27,923,471 (GRCm39) Y694H probably damaging Het
Eea1 C A 10: 95,877,346 (GRCm39) N1353K probably benign Het
Fam111a T A 19: 12,561,488 (GRCm39) probably null Het
Fat1 T C 8: 45,442,204 (GRCm39) S1169P probably benign Het
Frk G T 10: 34,360,067 (GRCm39) A23S probably benign Het
Fyb2 T C 4: 104,861,118 (GRCm39) V594A probably damaging Het
Gtpbp3 C A 8: 71,942,064 (GRCm39) probably benign Het
Hoxa5 G T 6: 52,179,688 (GRCm39) A229D probably damaging Het
Ift25 G A 4: 107,130,866 (GRCm39) C52Y possibly damaging Het
Igf2r A T 17: 12,913,007 (GRCm39) F1780L possibly damaging Het
Jade2 A T 11: 51,722,123 (GRCm39) D143E probably damaging Het
Kdm1a T C 4: 136,279,846 (GRCm39) I719V probably benign Het
Lama1 G A 17: 68,111,531 (GRCm39) G2261R probably damaging Het
Lmx1b G T 2: 33,457,216 (GRCm39) Q206K probably benign Het
Lrrtm4 G A 6: 79,998,786 (GRCm39) G66D probably damaging Het
Myg1 G T 15: 102,240,594 (GRCm39) G90C probably damaging Het
Nbea C T 3: 55,539,407 (GRCm39) V2785I probably benign Het
Ncr1 C A 7: 4,341,225 (GRCm39) P35Q probably damaging Het
Nos1 T A 5: 118,033,855 (GRCm39) C326S probably damaging Het
Or12j2 T C 7: 139,916,072 (GRCm39) F99S possibly damaging Het
Or3a1 G T 11: 74,225,519 (GRCm39) H179Q possibly damaging Het
Or52r1 A T 7: 102,537,243 (GRCm39) V39E possibly damaging Het
Pde4d A G 13: 110,084,795 (GRCm39) Y520C probably damaging Het
Ppm1d A G 11: 85,217,770 (GRCm39) M178V possibly damaging Het
Samd3 G A 10: 26,147,762 (GRCm39) R479K probably benign Het
Semp2l2b T A 10: 21,943,057 (GRCm39) I308F possibly damaging Het
Serpinb6a A G 13: 34,102,782 (GRCm39) V226A probably benign Het
Slc26a4 T C 12: 31,575,475 (GRCm39) E737G probably benign Het
Slc34a3 A G 2: 25,121,069 (GRCm39) C340R probably damaging Het
Spata31d1b C A 13: 59,866,941 (GRCm39) probably benign Het
Trappc12 A G 12: 28,797,013 (GRCm39) V173A probably benign Het
Vmn2r66 A T 7: 84,644,723 (GRCm39) D562E probably benign Het
Zfp395 C T 14: 65,633,344 (GRCm39) P451L probably benign Het
Other mutations in Ces2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Ces2b APN 8 105,561,236 (GRCm39) splice site probably benign
IGL01905:Ces2b APN 8 105,560,594 (GRCm39) missense probably damaging 1.00
IGL02528:Ces2b APN 8 105,561,601 (GRCm39) missense probably damaging 1.00
IGL02659:Ces2b APN 8 105,559,202 (GRCm39) splice site probably benign
PIT4142001:Ces2b UTSW 8 105,563,442 (GRCm39) missense probably damaging 1.00
R0092:Ces2b UTSW 8 105,563,144 (GRCm39) missense possibly damaging 0.48
R0403:Ces2b UTSW 8 105,560,577 (GRCm39) missense probably damaging 0.98
R0600:Ces2b UTSW 8 105,562,542 (GRCm39) missense probably benign 0.06
R0637:Ces2b UTSW 8 105,561,237 (GRCm39) splice site probably benign
R1574:Ces2b UTSW 8 105,562,521 (GRCm39) missense probably benign 0.16
R1574:Ces2b UTSW 8 105,562,521 (GRCm39) missense probably benign 0.16
R3036:Ces2b UTSW 8 105,561,258 (GRCm39) missense possibly damaging 0.87
R3086:Ces2b UTSW 8 105,559,401 (GRCm39) missense possibly damaging 0.92
R4761:Ces2b UTSW 8 105,563,193 (GRCm39) critical splice donor site probably null
R4920:Ces2b UTSW 8 105,563,538 (GRCm39) missense probably benign
R4937:Ces2b UTSW 8 105,559,413 (GRCm39) missense probably benign 0.29
R5211:Ces2b UTSW 8 105,561,695 (GRCm39) missense possibly damaging 0.89
R5550:Ces2b UTSW 8 105,565,069 (GRCm39) missense probably benign 0.00
R5790:Ces2b UTSW 8 105,560,568 (GRCm39) missense probably damaging 1.00
R6403:Ces2b UTSW 8 105,562,901 (GRCm39) nonsense probably null
R6692:Ces2b UTSW 8 105,563,919 (GRCm39) missense probably damaging 1.00
R6720:Ces2b UTSW 8 105,563,501 (GRCm39) missense probably benign 0.32
R6899:Ces2b UTSW 8 105,563,398 (GRCm39) splice site probably null
R7148:Ces2b UTSW 8 105,564,928 (GRCm39) missense probably damaging 1.00
R7270:Ces2b UTSW 8 105,564,472 (GRCm39) missense possibly damaging 0.50
R7571:Ces2b UTSW 8 105,561,641 (GRCm39) missense probably damaging 1.00
R7626:Ces2b UTSW 8 105,564,017 (GRCm39) missense possibly damaging 0.82
R7841:Ces2b UTSW 8 105,561,692 (GRCm39) missense probably benign 0.19
R7892:Ces2b UTSW 8 105,559,385 (GRCm39) missense probably damaging 1.00
R8029:Ces2b UTSW 8 105,561,482 (GRCm39) missense probably damaging 1.00
R8293:Ces2b UTSW 8 105,559,258 (GRCm39) missense unknown
R8296:Ces2b UTSW 8 105,563,112 (GRCm39) missense possibly damaging 0.77
R8721:Ces2b UTSW 8 105,560,527 (GRCm39) missense possibly damaging 0.88
R9100:Ces2b UTSW 8 105,558,221 (GRCm39) unclassified probably benign
R9361:Ces2b UTSW 8 105,564,039 (GRCm39) critical splice donor site probably null
R9461:Ces2b UTSW 8 105,564,011 (GRCm39) missense probably benign 0.39
R9477:Ces2b UTSW 8 105,560,556 (GRCm39) missense probably damaging 1.00
X0027:Ces2b UTSW 8 105,560,560 (GRCm39) missense probably damaging 1.00
Z1177:Ces2b UTSW 8 105,559,227 (GRCm39) frame shift probably null
Posted On 2015-12-18