Incidental Mutation 'IGL02885:Zfp395'
ID362954
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp395
Ensembl Gene ENSMUSG00000034522
Gene Namezinc finger protein 395
SynonymsLOC380912, BC027382
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02885
Quality Score
Status
Chromosome14
Chromosomal Location65358389-65398930 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 65395895 bp
ZygosityHeterozygous
Amino Acid Change Proline to Leucine at position 451 (P451L)
Ref Sequence ENSEMBL: ENSMUSP00000064422 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059339] [ENSMUST00000066994]
Predicted Effect probably benign
Transcript: ENSMUST00000059339
SMART Domains Protein: ENSMUSP00000054210
Gene: ENSMUSG00000045731

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Opiods_neuropep 20 66 1.4e-20 PFAM
low complexity region 109 131 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000066994
AA Change: P451L

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000064422
Gene: ENSMUSG00000034522
AA Change: P451L

DomainStartEndE-ValueType
Pfam:DUF4772 2 110 5.3e-31 PFAM
low complexity region 162 174 N/A INTRINSIC
low complexity region 208 234 N/A INTRINSIC
ZnF_C2H2 279 304 1.25e-1 SMART
low complexity region 356 367 N/A INTRINSIC
low complexity region 429 446 N/A INTRINSIC
c-clamp 478 508 1.88e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225512
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 82,063,951 N683S probably benign Het
4930444G20Rik T A 10: 22,067,158 I308F possibly damaging Het
Ahi1 T A 10: 21,055,113 F46I possibly damaging Het
Als2 C T 1: 59,167,491 V1598I probably benign Het
Arid1b A T 17: 5,342,153 D1986V probably damaging Het
Bhlhe41 T A 6: 145,865,263 D2V probably damaging Het
Borcs6 A G 11: 69,060,246 D150G possibly damaging Het
Ccdc88a G T 11: 29,448,050 R261L probably damaging Het
Ccne2 T A 4: 11,198,723 probably benign Het
Cenpk A G 13: 104,249,395 D266G probably damaging Het
Ces2b T C 8: 104,834,931 V219A probably damaging Het
Cpa1 A G 6: 30,645,170 R382G probably damaging Het
Cplx4 G T 18: 65,956,913 T145N probably damaging Het
Cyp19a1 T C 9: 54,171,818 I269V probably benign Het
Dennd3 A G 15: 73,568,696 Y1192C probably benign Het
Dpp6 T C 5: 27,718,473 Y694H probably damaging Het
Eea1 C A 10: 96,041,484 N1353K probably benign Het
Fam111a T A 19: 12,584,124 probably null Het
Fat1 T C 8: 44,989,167 S1169P probably benign Het
Frk G T 10: 34,484,071 A23S probably benign Het
Fyb2 T C 4: 105,003,921 V594A probably damaging Het
Gtpbp3 C A 8: 71,489,420 probably benign Het
Hoxa5 G T 6: 52,202,708 A229D probably damaging Het
Hspb11 G A 4: 107,273,669 C52Y possibly damaging Het
Igf2r A T 17: 12,694,120 F1780L possibly damaging Het
Jade2 A T 11: 51,831,296 D143E probably damaging Het
Kdm1a T C 4: 136,552,535 I719V probably benign Het
Lama1 G A 17: 67,804,536 G2261R probably damaging Het
Lmx1b G T 2: 33,567,204 Q206K probably benign Het
Lrrtm4 G A 6: 80,021,803 G66D probably damaging Het
Myg1 G T 15: 102,332,159 G90C probably damaging Het
Nbea C T 3: 55,631,986 V2785I probably benign Het
Ncr1 C A 7: 4,338,226 P35Q probably damaging Het
Nos1 T A 5: 117,895,790 C326S probably damaging Het
Olfr410 G T 11: 74,334,693 H179Q possibly damaging Het
Olfr527 T C 7: 140,336,159 F99S possibly damaging Het
Olfr569 A T 7: 102,888,036 V39E possibly damaging Het
Pde4d A G 13: 109,948,261 Y520C probably damaging Het
Ppm1d A G 11: 85,326,944 M178V possibly damaging Het
Samd3 G A 10: 26,271,864 R479K probably benign Het
Serpinb6a A G 13: 33,918,799 V226A probably benign Het
Slc26a4 T C 12: 31,525,476 E737G probably benign Het
Slc34a3 A G 2: 25,231,057 C340R probably damaging Het
Spata31d1b C A 13: 59,719,127 probably benign Het
Trappc12 A G 12: 28,747,014 V173A probably benign Het
Vmn2r66 A T 7: 84,995,515 D562E probably benign Het
Other mutations in Zfp395
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01301:Zfp395 APN 14 65394751 splice site probably null
IGL01712:Zfp395 APN 14 65386387 missense probably damaging 0.98
R0243:Zfp395 UTSW 14 65386480 missense probably benign
R1540:Zfp395 UTSW 14 65393074 missense probably benign
R2005:Zfp395 UTSW 14 65388885 missense possibly damaging 0.87
R2108:Zfp395 UTSW 14 65393116 missense probably benign 0.24
R3499:Zfp395 UTSW 14 65391293 missense possibly damaging 0.87
R4790:Zfp395 UTSW 14 65386541 missense possibly damaging 0.74
R4790:Zfp395 UTSW 14 65393207 missense probably damaging 1.00
R6978:Zfp395 UTSW 14 65386433 missense probably benign 0.05
RF024:Zfp395 UTSW 14 65385425 missense unknown
Posted On2015-12-18