Incidental Mutation 'IGL02886:Taf13'
ID 363030
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Taf13
Ensembl Gene ENSMUSG00000048100
Gene Name TATA-box binding protein associated factor 13
Synonyms 1810004N01Rik, 2010309N11Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02886
Quality Score
Status
Chromosome 3
Chromosomal Location 108479015-108489384 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) T to C at 108488500 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000143054]
AlphaFold P61216
Predicted Effect noncoding transcript
Transcript: ENSMUST00000056292
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131814
Predicted Effect probably benign
Transcript: ENSMUST00000143054
SMART Domains Protein: ENSMUSP00000121346
Gene: ENSMUSG00000048100

DomainStartEndE-ValueType
low complexity region 4 26 N/A INTRINSIC
Pfam:TFIID-18kDa 30 119 1.6e-41 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T A 3: 121,921,863 (GRCm39) C1140S probably damaging Het
Abhd12b T C 12: 70,229,740 (GRCm39) I238T possibly damaging Het
Adgrb3 T C 1: 25,543,991 (GRCm39) probably null Het
Baz2b A T 2: 59,788,087 (GRCm39) probably null Het
Brwd3 T C X: 107,794,454 (GRCm39) Y1410C probably damaging Het
Casp7 T A 19: 56,421,775 (GRCm39) I71N probably damaging Het
Cspg4 A T 9: 56,804,672 (GRCm39) I1828F probably damaging Het
Cul2 T C 18: 3,426,920 (GRCm39) probably benign Het
Efcab3 A G 11: 104,986,700 (GRCm39) D5409G possibly damaging Het
Fam187a A T 11: 102,777,380 (GRCm39) T395S probably benign Het
Fcgr2b A G 1: 170,793,297 (GRCm39) V244A possibly damaging Het
Fubp1 A G 3: 151,926,392 (GRCm39) E333G possibly damaging Het
Ganab G T 19: 8,888,391 (GRCm39) probably benign Het
Hpdl A G 4: 116,677,952 (GRCm39) S170P probably benign Het
Hsd17b7 C T 1: 169,780,649 (GRCm39) E320K probably damaging Het
Klhl11 T C 11: 100,363,047 (GRCm39) S170G possibly damaging Het
Lrrc56 A G 7: 140,777,090 (GRCm39) probably benign Het
Lrrd1 T C 5: 3,901,534 (GRCm39) V613A probably benign Het
Myo1e T C 9: 70,276,055 (GRCm39) F757L probably benign Het
Myo5a T A 9: 75,059,169 (GRCm39) probably benign Het
Myocd T A 11: 65,069,569 (GRCm39) D837V probably damaging Het
Naip6 T C 13: 100,436,984 (GRCm39) Q513R possibly damaging Het
Nol4l A G 2: 153,371,457 (GRCm39) F76L probably benign Het
Or10ak7 T C 4: 118,792,027 (GRCm39) E6G probably benign Het
Or2b2b T A 13: 21,859,122 (GRCm39) probably benign Het
Or5b98 T A 19: 12,931,882 (GRCm39) S310T probably benign Het
Pck1 G A 2: 172,996,649 (GRCm39) E188K probably benign Het
Pdcd11 T C 19: 47,102,064 (GRCm39) V1083A possibly damaging Het
Primpol G A 8: 47,046,619 (GRCm39) Q226* probably null Het
Rbm15 A C 3: 107,233,611 (GRCm39) V959G probably benign Het
Rorb A G 19: 18,954,943 (GRCm39) probably null Het
Spata9 T C 13: 76,125,853 (GRCm39) L112P probably damaging Het
Stk24 A T 14: 121,529,527 (GRCm39) L375Q probably null Het
Svip A G 7: 51,655,509 (GRCm39) S11P possibly damaging Het
Tex30 T C 1: 44,127,683 (GRCm39) Y7C probably damaging Het
Tmem68 T C 4: 3,569,361 (GRCm39) probably benign Het
Tnc T C 4: 63,918,344 (GRCm39) E1189G probably damaging Het
Top2b T C 14: 16,365,688 (GRCm38) S4P possibly damaging Het
Trav3-3 C A 14: 53,903,822 (GRCm39) L47I probably benign Het
Ttn G A 2: 76,733,557 (GRCm39) probably benign Het
Uroc1 A G 6: 90,323,811 (GRCm39) probably benign Het
Other mutations in Taf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0302:Taf13 UTSW 3 108,479,038 (GRCm39) start codon destroyed probably null
R1712:Taf13 UTSW 3 108,488,445 (GRCm39) missense possibly damaging 0.92
R3760:Taf13 UTSW 3 108,485,424 (GRCm39) splice site probably benign
R4660:Taf13 UTSW 3 108,480,293 (GRCm39) intron probably benign
R5195:Taf13 UTSW 3 108,488,390 (GRCm39) missense probably damaging 1.00
R6001:Taf13 UTSW 3 108,488,387 (GRCm39) missense probably damaging 1.00
R8738:Taf13 UTSW 3 108,485,444 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18