Incidental Mutation 'IGL02895:Or4c11c'
ID |
363372 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Or4c11c
|
Ensembl Gene |
ENSMUSG00000057447 |
Gene Name |
olfactory receptor family 4 subfamily C member 11C |
Synonyms |
GA_x6K02T2Q125-50336588-50337313, MOR230-1, MOR230-3, Olfr1205, GA_x6K02T2Q125-50304328-50305251, Olfr1203 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.050)
|
Stock # |
IGL02895
|
Quality Score |
|
Status
|
|
Chromosome |
2 |
Chromosomal Location |
88660101-88662386 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 88661986 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Cysteine
at position 175
(Y175C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000150206
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076438]
[ENSMUST00000215929]
|
AlphaFold |
A2ATJ7 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000076438
AA Change: Y175C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000075769 Gene: ENSMUSG00000057447 AA Change: Y175C
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
29 |
303 |
5e-45 |
PFAM |
Pfam:7tm_1
|
39 |
285 |
9.1e-21 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000215929
AA Change: Y175C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 19 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ahctf1 |
C |
T |
1: 179,621,376 (GRCm39) |
E130K |
probably damaging |
Het |
Atf7ip |
C |
A |
6: 136,537,686 (GRCm39) |
S306R |
probably damaging |
Het |
Cpd |
A |
G |
11: 76,676,029 (GRCm39) |
V1208A |
probably benign |
Het |
Cplane1 |
A |
G |
15: 8,261,591 (GRCm39) |
|
probably benign |
Het |
Ctsl |
C |
T |
13: 64,514,326 (GRCm39) |
A195T |
probably damaging |
Het |
Dennd2c |
T |
C |
3: 103,044,519 (GRCm39) |
Y367H |
possibly damaging |
Het |
Endod1 |
T |
A |
9: 14,268,166 (GRCm39) |
T440S |
probably benign |
Het |
Gm12695 |
T |
C |
4: 96,612,186 (GRCm39) |
R526G |
probably damaging |
Het |
Ighv1-39 |
T |
C |
12: 114,878,302 (GRCm39) |
T90A |
probably damaging |
Het |
Kdm2a |
G |
A |
19: 4,412,930 (GRCm39) |
R19C |
probably damaging |
Het |
Klra1 |
C |
T |
6: 130,352,203 (GRCm39) |
E180K |
possibly damaging |
Het |
Odam |
A |
G |
5: 88,033,723 (GRCm39) |
Q21R |
probably benign |
Het |
Or8b8 |
G |
A |
9: 37,809,278 (GRCm39) |
V193I |
probably benign |
Het |
Plk1 |
A |
G |
7: 121,768,389 (GRCm39) |
E504G |
possibly damaging |
Het |
Rtl3 |
T |
C |
X: 105,883,150 (GRCm39) |
I37M |
possibly damaging |
Het |
Srebf2 |
A |
G |
15: 82,031,668 (GRCm39) |
E22G |
possibly damaging |
Het |
Tmem74b |
A |
G |
2: 151,548,311 (GRCm39) |
S13G |
probably benign |
Het |
Utp14b |
T |
C |
1: 78,642,324 (GRCm39) |
V74A |
possibly damaging |
Het |
Znrf3 |
T |
C |
11: 5,239,085 (GRCm39) |
M93V |
probably damaging |
Het |
|
Other mutations in Or4c11c |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00923:Or4c11c
|
APN |
2 |
88,661,456 (GRCm39) |
splice site |
probably null |
|
IGL02079:Or4c11c
|
APN |
2 |
88,661,991 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02183:Or4c11c
|
APN |
2 |
88,662,372 (GRCm39) |
missense |
probably benign |
|
IGL02813:Or4c11c
|
APN |
2 |
88,661,495 (GRCm39) |
missense |
probably benign |
0.34 |
IGL02839:Or4c11c
|
APN |
2 |
88,661,992 (GRCm39) |
missense |
probably damaging |
1.00 |
R0680:Or4c11c
|
UTSW |
2 |
88,662,124 (GRCm39) |
missense |
probably benign |
|
R2029:Or4c11c
|
UTSW |
2 |
88,661,749 (GRCm39) |
missense |
possibly damaging |
0.88 |
R2095:Or4c11c
|
UTSW |
2 |
88,661,634 (GRCm39) |
missense |
probably damaging |
1.00 |
R6158:Or4c11c
|
UTSW |
2 |
88,661,490 (GRCm39) |
missense |
probably damaging |
1.00 |
R6216:Or4c11c
|
UTSW |
2 |
88,661,655 (GRCm39) |
missense |
probably damaging |
1.00 |
R6240:Or4c11c
|
UTSW |
2 |
88,661,707 (GRCm39) |
missense |
probably benign |
0.22 |
R6377:Or4c11c
|
UTSW |
2 |
88,661,613 (GRCm39) |
nonsense |
probably null |
|
R6429:Or4c11c
|
UTSW |
2 |
88,661,869 (GRCm39) |
missense |
probably benign |
0.01 |
R6521:Or4c11c
|
UTSW |
2 |
88,661,700 (GRCm39) |
missense |
probably benign |
0.03 |
R7065:Or4c11c
|
UTSW |
2 |
88,661,730 (GRCm39) |
missense |
probably damaging |
1.00 |
R7343:Or4c11c
|
UTSW |
2 |
88,662,190 (GRCm39) |
missense |
probably damaging |
1.00 |
R7476:Or4c11c
|
UTSW |
2 |
88,661,932 (GRCm39) |
missense |
probably benign |
0.07 |
R7570:Or4c11c
|
UTSW |
2 |
88,661,472 (GRCm39) |
missense |
possibly damaging |
0.82 |
R8303:Or4c11c
|
UTSW |
2 |
88,661,633 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8306:Or4c11c
|
UTSW |
2 |
88,661,633 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8307:Or4c11c
|
UTSW |
2 |
88,661,633 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8308:Or4c11c
|
UTSW |
2 |
88,661,633 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8344:Or4c11c
|
UTSW |
2 |
88,661,727 (GRCm39) |
missense |
probably benign |
0.00 |
R8386:Or4c11c
|
UTSW |
2 |
88,661,633 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8387:Or4c11c
|
UTSW |
2 |
88,661,633 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8809:Or4c11c
|
UTSW |
2 |
88,662,256 (GRCm39) |
missense |
probably benign |
0.01 |
R8894:Or4c11c
|
UTSW |
2 |
88,661,809 (GRCm39) |
missense |
probably benign |
0.12 |
Z1176:Or4c11c
|
UTSW |
2 |
88,661,922 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Posted On |
2015-12-18 |