Incidental Mutation 'IGL02895:Olfr1205'
ID363372
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1205
Ensembl Gene ENSMUSG00000057447
Gene Nameolfactory receptor 1205
SynonymsMOR230-1, MOR230-3, Olfr1203, GA_x6K02T2Q125-50304328-50305251, GA_x6K02T2Q125-50336588-50337313
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #IGL02895
Quality Score
Status
Chromosome2
Chromosomal Location88829737-88837104 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 88831642 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 175 (Y175C)
Ref Sequence ENSEMBL: ENSMUSP00000150206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076438] [ENSMUST00000215929]
Predicted Effect probably damaging
Transcript: ENSMUST00000076438
AA Change: Y175C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075769
Gene: ENSMUSG00000057447
AA Change: Y175C

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 5e-45 PFAM
Pfam:7tm_1 39 285 9.1e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215929
AA Change: Y175C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A G 15: 8,232,107 probably benign Het
Ahctf1 C T 1: 179,793,811 E130K probably damaging Het
Atf7ip C A 6: 136,560,688 S306R probably damaging Het
Cpd A G 11: 76,785,203 V1208A probably benign Het
Ctsl C T 13: 64,366,512 A195T probably damaging Het
Dennd2c T C 3: 103,137,203 Y367H possibly damaging Het
Endod1 T A 9: 14,356,870 T440S probably benign Het
Gm12695 T C 4: 96,723,949 R526G probably damaging Het
Ighv1-39 T C 12: 114,914,682 T90A probably damaging Het
Kdm2a G A 19: 4,362,902 R19C probably damaging Het
Klra1 C T 6: 130,375,240 E180K possibly damaging Het
Odam A G 5: 87,885,864 Q21R probably benign Het
Olfr145 G A 9: 37,897,982 V193I probably benign Het
Plk1 A G 7: 122,169,166 E504G possibly damaging Het
Rtl3 T C X: 106,839,544 I37M possibly damaging Het
Srebf2 A G 15: 82,147,467 E22G possibly damaging Het
Tmem74b A G 2: 151,706,391 S13G probably benign Het
Utp14b T C 1: 78,664,607 V74A possibly damaging Het
Znrf3 T C 11: 5,289,085 M93V probably damaging Het
Other mutations in Olfr1205
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Olfr1205 APN 2 88831112 splice site probably null
IGL02079:Olfr1205 APN 2 88831647 missense probably damaging 1.00
IGL02183:Olfr1205 APN 2 88832028 missense probably benign
IGL02813:Olfr1205 APN 2 88831151 missense probably benign 0.34
IGL02839:Olfr1205 APN 2 88831648 missense probably damaging 1.00
R0680:Olfr1205 UTSW 2 88831780 missense probably benign
R2029:Olfr1205 UTSW 2 88831405 missense possibly damaging 0.88
R2095:Olfr1205 UTSW 2 88831290 missense probably damaging 1.00
R6158:Olfr1205 UTSW 2 88831146 missense probably damaging 1.00
R6216:Olfr1205 UTSW 2 88831311 missense probably damaging 1.00
R6240:Olfr1205 UTSW 2 88831363 missense probably benign 0.22
R6377:Olfr1205 UTSW 2 88831269 nonsense probably null
R6429:Olfr1205 UTSW 2 88831525 missense probably benign 0.01
R6521:Olfr1205 UTSW 2 88831356 missense probably benign 0.03
R7065:Olfr1205 UTSW 2 88831386 missense probably damaging 1.00
R7343:Olfr1205 UTSW 2 88831846 missense probably damaging 1.00
R7476:Olfr1205 UTSW 2 88831588 missense probably benign 0.07
R7570:Olfr1205 UTSW 2 88831128 missense possibly damaging 0.82
R8303:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8306:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8307:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8308:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8344:Olfr1205 UTSW 2 88831383 missense probably benign 0.00
R8386:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
R8387:Olfr1205 UTSW 2 88831289 missense possibly damaging 0.90
Z1176:Olfr1205 UTSW 2 88831578 missense probably damaging 0.99
Posted On2015-12-18