Incidental Mutation 'IGL02895:Olfr145'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr145
Ensembl Gene ENSMUSG00000066748
Gene Nameolfactory receptor 145
SynonymsK21, MOR161-6, GA_x6K02T2PVTD-31578734-31579666
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.118) question?
Stock #IGL02895
Quality Score
Chromosomal Location37896724-37903519 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 37897982 bp
Amino Acid Change Valine to Isoleucine at position 193 (V193I)
Ref Sequence ENSEMBL: ENSMUSP00000150284 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086062] [ENSMUST00000213688]
Predicted Effect probably benign
Transcript: ENSMUST00000086062
AA Change: V193I

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000083229
Gene: ENSMUSG00000066748
AA Change: V193I

Pfam:7tm_4 30 307 4e-51 PFAM
Pfam:7tm_1 40 289 1.4e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213688
AA Change: V193I

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A G 15: 8,232,107 probably benign Het
Ahctf1 C T 1: 179,793,811 E130K probably damaging Het
Atf7ip C A 6: 136,560,688 S306R probably damaging Het
Cpd A G 11: 76,785,203 V1208A probably benign Het
Ctsl C T 13: 64,366,512 A195T probably damaging Het
Dennd2c T C 3: 103,137,203 Y367H possibly damaging Het
Endod1 T A 9: 14,356,870 T440S probably benign Het
Gm12695 T C 4: 96,723,949 R526G probably damaging Het
Ighv1-39 T C 12: 114,914,682 T90A probably damaging Het
Kdm2a G A 19: 4,362,902 R19C probably damaging Het
Klra1 C T 6: 130,375,240 E180K possibly damaging Het
Odam A G 5: 87,885,864 Q21R probably benign Het
Olfr1205 A G 2: 88,831,642 Y175C probably damaging Het
Plk1 A G 7: 122,169,166 E504G possibly damaging Het
Rtl3 T C X: 106,839,544 I37M possibly damaging Het
Srebf2 A G 15: 82,147,467 E22G possibly damaging Het
Tmem74b A G 2: 151,706,391 S13G probably benign Het
Utp14b T C 1: 78,664,607 V74A possibly damaging Het
Znrf3 T C 11: 5,289,085 M93V probably damaging Het
Other mutations in Olfr145
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01362:Olfr145 APN 9 37898063 missense probably benign 0.13
IGL01586:Olfr145 APN 9 37897976 missense possibly damaging 0.73
IGL02185:Olfr145 APN 9 37898235 missense probably damaging 1.00
IGL02956:Olfr145 APN 9 37898108 missense probably damaging 1.00
R0391:Olfr145 UTSW 9 37897842 missense probably benign 0.31
R0513:Olfr145 UTSW 9 37898055 missense probably damaging 1.00
R4600:Olfr145 UTSW 9 37898326 missense probably benign
R4610:Olfr145 UTSW 9 37898326 missense probably benign
R4611:Olfr145 UTSW 9 37898326 missense probably benign
R4982:Olfr145 UTSW 9 37897515 missense probably damaging 1.00
R5574:Olfr145 UTSW 9 37897581 missense probably damaging 1.00
R5608:Olfr145 UTSW 9 37897782 missense probably damaging 0.98
R5688:Olfr145 UTSW 9 37898063 missense possibly damaging 0.91
R5906:Olfr145 UTSW 9 37897878 missense probably damaging 1.00
R6286:Olfr145 UTSW 9 37897778 missense probably damaging 0.99
R7138:Olfr145 UTSW 9 37898064 missense probably damaging 0.99
R7145:Olfr145 UTSW 9 37897563 missense probably benign 0.01
R7993:Olfr145 UTSW 9 37897337 intron probably benign
R8046:Olfr145 UTSW 9 37897389 splice site probably benign
R8185:Olfr145 UTSW 9 37898235 missense probably damaging 1.00
X0012:Olfr145 UTSW 9 37898328 nonsense probably null
Posted On2015-12-18